| 1. |
- Martin-Sanchez, F., et al.
(författare)
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Synergy between medical informatics and bioinformatics : Facilitating genomic medicine for future health care
- 2004
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Ingår i: Journal of Biomedical Informatics. - : Elsevier BV. - 1532-0464 .- 1532-0480. ; 37:1, s. 30-42
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Tidskriftsartikel (refereegranskat)abstract
- In this paper, we review the results of BIOINFOMED, a study funded by the European Commission (EC) with the purpose to analyse the different issues and challenges in the area where Medical Informatics and Bioinformatics meet. Traditionally, Medical Informatics has been focused on the intersection between computer science and clinical medicine, whereas Bioinformatics have been predominantly centered on the intersection between computer science and biological research. Although researchers from both areas have occasionally collaborated, their training, objectives and interests have been quite different. The results of the Human Genome and related projects have attracted the interest of many professionals, and introduced new challenges that will transform biomedical research and health care. A characteristic of the 'post genomic' era will be to correlate essential genotypic information with expressed phenotypic information. In this context, Biomedical Informatics (BMI) has emerged to describe the technology that brings both disciplines (BI and MI) together to support genomic medicine. In recognition of the dynamic nature of BMI, institutions such as the EC have launched several initiatives in support of a research agenda, including the BIOINFOMED study.
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| 2. |
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| 3. |
- Langlet, Abraham, et al.
(författare)
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Formation of Nitroform in the Nitration of gem-Dinitro Compounds
- 2004
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Ingår i: Propellants, explosives, pyrotechnics. - : Wiley. - 0721-3115 .- 1521-4087. ; 29:6, s. 344-348
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Tidskriftsartikel (refereegranskat)abstract
- Nitration of 4,6-dihydroxypyrimidine in sulphuric acid gave nitroform as the sole product. This behaviour was tentatively explained by the formation of an intermediate, 5,5-dinitro-4,6-dihydroxypyrimidine, that underwent hydrolysis in the nitrating acid to gem-dinitroacetyl formamidine. This compound was further nitrated in the same reaction mixture to trinitroacetylformamidine which finally underwent hydrolytic cleavage to nitroform. It was also demonstrated that gem-dinitroacetyl ureas were able to produce nitroform on nitration. The structures of the proposed trinitroacetylureas were confirmed by the isolation of one of their derivatives.
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| 4. |
- Langlet, Abraham, et al.
(författare)
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Nitration of 2-substituted pyrimidine-4,6-diones, structure and reactivity of 5,5-gem-dinitropyrimidine-4,6-diones
- 2002
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Ingår i: Journal of Organic Chemistry. - : American Chemical Society (ACS). - 0022-3263 .- 1520-6904. ; 67:22, s. 7833-7838
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Tidskriftsartikel (refereegranskat)abstract
- Nitration of some 2-substituted pyrimidine-4,6-diones in sulfuric acid was studied, which afforded previously unknown 5,5-gem-dinitropyrimidine-4,6-diones in high yields. The gem-dinitro products were easily attacked by nucleophiles with concomitant formation of gem-dinitroacetyl derivatives, which in turn could be further hydrolyzed to salts of dinitromethane and triureas.
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| 5. |
- Langlet, Abraham, et al.
(författare)
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Synthesis and reaction of 5,5-dinitrobarbituric acid
- 2000
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Ingår i: Tetrahedron Letters. - 0040-4039 .- 1359-8562. ; 41:12, s. 2011-2013
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Tidskriftsartikel (refereegranskat)abstract
- Nitration of barbituric acid at 40°C gave the previously unknown 5,5- dinitrobarbituric acid (3), which readily underwent hydrolysis to dinitroacetylurea (5), which in turn could be hydrolysed in basic media to the potassium salt of dinitromethane. Alloxane was prepared in a one step procedure by thermal decomposition of 5,5-dinitrobarbituric acid in hot acetic acid.
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