| 1. |
- Korkalainen, Henri, et al.
(författare)
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Review and perspective on sleep-disordered breathing research and translation to clinics
- 2024
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Ingår i: SLEEP MEDICINE REVIEWS. - 1087-0792 .- 1532-2955. ; 73
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Forskningsöversikt (refereegranskat)abstract
- Sleep-disordered breathing, ranging from habitual snoring to severe obstructive sleep apnea, is a prevalent public health issue. Despite rising interest in sleep and awareness of sleep disorders, sleep research and diagnostic practices still rely on outdated metrics and laborious methods reducing the diagnostic capacity and preventing timely diagnosis and treatment. Consequently, a significant portion of individuals affected by sleep-disordered breathing remain undiagnosed or are misdiagnosed. Taking advantage of state-of-the-art scientific, technological, and computational advances could be an effective way to optimize the diagnostic and treatment pathways. We discuss state-of-the-art multidisciplinary research, review the shortcomings in the current practices of SDB diagnosis and management in adult populations, and provide possible future directions. We critically review the opportunities for modern data analysis methods and machine learning to combine multimodal information, provide a perspective on the pitfalls of big data analysis, and discuss approaches for developing analysis strategies that overcome current limitations. We argue that large-scale and multidisciplinary collaborative efforts based on clinical, scientific, and technical knowledge and rigorous clinical validation and implementation of the outcomes in practice are needed to move the research of sleep-disordered breathing forward, thus increasing the quality of diagnostics and treatment.
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| 2. |
- Ólafsdóttir, Helga Kristín, 1990, et al.
(författare)
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Locally tail-scale invariant scoring rules for evaluation of extreme value forecasts
- 2024
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Ingår i: International Journal of Forecasting. - 0169-2070. ; In Press
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Tidskriftsartikel (refereegranskat)abstract
- Statistical analysis of extremes can be used to predict the probability of future extreme events, such as large rainfalls or devastating windstorms. The quality of these forecasts can be measured through scoring rules. Locally scale invariant scoring rules give equal importance to the forecasts at different locations regardless of differences in the prediction uncertainty. This is a useful feature when computing average scores but can be an unnecessarily strict requirement when one is mostly concerned with extremes. We propose the concept of local weight-scale invariance, describing scoring rules fulfilling local scale invariance in a certain region of interest, and as a special case, local tail-scale invariance for large events. Moreover, a new version of the weighted continuous ranked probability score (wCRPS) called the scaled wCRPS (swCRPS) that possesses this property is developed and studied. The score is a suitable alternative for scoring extreme value models over areas with a varying scale of extreme events, and we derive explicit formulas of the score for the generalised extreme value distribution. The scoring rules are compared through simulations, and their usage is illustrated by modelling extreme water levels and annual maximum rainfall, and in an application to non-extreme forecasts for the prediction of air pollution.
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