| 1. |
- Chaudhry, A, et al.
(author)
-
Expression of transforming growth factor b1, b2, b3 in neuroendocrine tumors of the digestive system
- 1994
-
In: Anticancer Res. ; 14, s. 2085-
-
Journal article (peer-reviewed)abstract
- Ligand induced activation of the beta-receptor for platelet-derived growth factor (PDGF) leads to activation of Src family tyrosine kinases. We have explored the possibility that the receptor itself is a substrate for Src. We show that Tyr934 in the kinase domain of the PDGF receptor is phosphorylated by Src. Cell lines expressing a beta-receptor mutant, in which Tyr934 was replaced with a phenyalanine residue, showed reduced mitogenic signaling in response to PDGF-BB. In contrast, the mutant receptor mediated increased signals for chemotaxis and actin reorganization. Whereas the motility responses of cells expressing wild-type beta-receptors were attenuated by inhibition of phosphatidylinositol 3'-kinase, those of cells expressing the mutant receptor were only slightly influenced. In contrast, PDGF-BB-induced chemotaxis of the cells with the mutant receptor was attenuated by inhibition of protein kinase C, whereas the chemotaxis of cells expressing the wild-type beta-receptor was less affected. Moreover, the PDGF-BB-stimulated tyrosine phosphorylation of phospholipase C-gamma was increased in the mutant receptor cells compared with wild-type receptor cells. In conclusion, the characteristics of the Y934F mutant suggest that the phosphorylation of Tyr934 by Src negatively modulates a signal transduction pathway leading to motility responses which involves phospholipase C-gamma, and shifts the response to increased mitogenicity.
|
|
| 2. |
|
|
| 3. |
- Ruth, Jan-Erik, et al.
(author)
-
Old age and loneliness illustrated by the Zulliger
- 1990
-
In: British Journal of Projective Psychology. - 0957-7785. ; 25:2, s. 61-73
-
Journal article (other academic/artistic)abstract
- Investigated the personality structure in old age, focusing on sociability and loneliness, using the Zulliger Individual and Group Test among 32 noninstitutionalized elderly adults (aged 75–85 yrs) and 36 control adults (aged 31–60 yrs). 15 elderly Ss were considered to be sociable, and 17 were considered to be lonely. J. E. Exner's (1986) comprehensive Rorschach system was used to analyze the data. Sociable Ss were lively and independent, although slightly aggressive and hostile. They showed signs of helplessness and experienced feelings of uneasiness. These Ss retained more liveliness with respect to their basic personality structure compared with lonely Ss. Lonely Ss were more prone to withdraw and simplify their conception of the surrounding world.
|
|
| 4. |
- Wallman, Carl-Gustaf, et al.
(author)
-
Effects of winter road maintenance : state-of-the-art
- 1997
-
Reports (other academic/artistic)abstract
- The study constitutes the basis for the model to be used as a guideline for determining winter road standards within the framework of the public economy. Driving speeds vary widely on winter roads. However, it is estimated that passenger cars travel at 75-–90 % of the speeds they normally travel at on bare roads. In order to maintain a consistent stopping distance, speeds should virtually be halved. The appearance of the road has a greater affect on the reduction in speed than friction/road traction. Precipitation entails a much greater reduction than slippery road surfaces alone. Accident rates on winter roads vary greatly. However, studies based on the observation of road conditions and traffic measurements show an increased risk on icy/snowy roads. The more unusual these conditions, the greater the risk. Aggregated studies do not support the presumption of increased risk in winter. Statistics from the Swedish Motor Vehicle Inspection Co. were analysed as a result of notations of rust defects that caused cars to fail inspection. In Västervik, where roads are salted, cars fail inspection 2–4times more often than on Gotland, where salt is not used. Experts estimate that the life expectancy of cars would increase by 25 % if roads were not salted. Corrosion costs will continue to be high since new corrosion problems occur in conjunction with the effects on electronic equipment. Many breaches of knowledge are identified.
|
|
| 5. |
|
|
