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- Lindberg, Olof, et al.
(författare)
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Cortical morphometric subclassification of frontotemporal lobar degeneration
- 2009
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Ingår i: American Journal of Neuroradiology. - 0195-6108 .- 1936-959X. ; 30:6, s. 1233-1239
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Tidskriftsartikel (refereegranskat)abstract
- BACKGROUND AND PURPOSE: Frontotemporal lobar degeneration (FTLD) is a primary neurodegenerative disease comprising 3 clinical subtypes: frontotemporal dementia (FTD), semantic dementia (SD), and progressive nonfluent aphasia (PNFA). The subdivision is primarily based on the characteristic clinical symptoms displayed by each subtype. We hypothesized that these symptoms would be correlated to characteristic patterns of brain atrophy, which could be indentified and used for subclassification of subjects with FTLD. MATERIALS AND METHODS: Volumes of 9 cortical regions were manually parcellated and measured on both hemispheres on 27 controls, 12 patients with FTD, 9 patients with PNFA, and 13 patients with SD. The volumetric data were analyzed by traditional t tests and by a multivariate discriminant analysis (partial least squares discriminant analysis). RESULTS: The ensemble or pattern of atrophy was a good discriminator in pair-wise comparison between the subtypes: FTD compared with SD (sensitivity 100% [12/12], specificity 100% [13/13]); FTD compared with PNFA (sensitivity 92% [11/12], specificity 89% [8/9]); and SD compared with PNFA (sensitivity 86% [11/13], specificity 100% [9/9]). Temporal-versus-frontal atrophy was the most important pattern for discriminating SD from the other 2 subtypes. Right-sided versus left-sided atrophy was the most important pattern for discriminating between subjects with FTD and PNFA. CONCLUSIONS: FTLD subtypes generally display a characteristic pattern of atrophy, which may be considered in diagnosing patients with FTLD.
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- Overud, Johanna
(författare)
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I beredskap med Fru Lojal : behovet av kvinnlig arbetskraft i Sverige under andra världskriget
- 2005
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Doktorsavhandling (övrigt vetenskapligt/konstnärligt)abstract
- Women’s wartime work is a well-known phenomenon in belligerent countries. But what happened in a neutral country like Sweden? With the outbreak of the Second World War, Sweden was put in a state of “national preparedness” that would last from September 1939 until the end of war in May 1945. From the autumn of 1939 the State Labour Market Commission (Statens arbetsmarknadskommission, SAK) had sent out signals to the employers’ associations in the engineering industry and at the ironworks that their male employees would not be granted exemptions from military service. Employers therefore had to find reserve workers, either men too old to be conscripted or women. The main purpose of this thesis is to explore how the threat of war affected the plans for and the use of women’s labour during the years of national preparedness.The national preparedness organisation did not include a plan ready for use to mobilise women either for work or for voluntary efforts for the nation during this period. The absence of a state plan for women’s national efforts became the point of departure for the Women's Organisations' Preparedness Committee, (Kvinnoföreningarnas beredskapskommitté, KBK) in 1938. The founding intention of this organisation was to gather Swedish women as a demonstration of their will to defend their country. A huge number of women – 800 000 – signed up for various tasks. This organisation was dominated by women who were eager to contribute to the national defence, and was not fully representative of the traditional women’s movement.With the passing of The National Compulsory Service Act (tjänstepliktslag) in December 1939 both men and women had become eligible for conscription. This was supposed to provide an instrument through which the government would be able to guarantee the supply of industrial labour. But the National Compulsory Service Act was never put into effect with regard to women. Instead, the governmental strategy to reach the female workforce was to establish a liaison between the state and the KBK.The Swedish way was the volunteer way. But this policy required propaganda. And so “Mrs. Loyal” made her entry in a state initiated propaganda newsreel on Swedish cinemas in January 1944. Mrs. Loyal was introduced as an example of “the national preparedness woman of today”. As a reserve worker in the engineering industry, she replaced a man who was called up for military service. The Mrs Loyal propaganda was aimed at married women whose children were grown up. The film presented the ideal situation where women registered for these courses voluntarily, to be fully trained if and when they were needed in industry.Towards the end of the war the SAK made inquiries to investigate the outcome of industrial employment during the war years. It then appeared that the Mrs Loyal-campaign had had an unexpected result. Few of the married housewives Mrs Loyal was supposed to attract had followed her example. In reality, it was a different group of women who took advantage of the opportunity. Young, unmarried women – daughters who still lived at home – saw an opening for them to leave home and earn their own livings. For these young women the preparedness situation and labour shortage actually became an opportunity for emancipation.How are we to understand the significance of the years 1939–1945 in terms of gender relations? The years of national preparedness in Sweden never became the opportunity for a broad range of women to leave their homes and become wage earners. In terms of gender contract, the housewife contract remained dominant. The traditional gender order never changed. The call for women workers was never a question of equal rights, just the temporary needs of the nation. But even if the changes were as superficial as the propaganda image, the need for women workers led to some changes. The question of equal pay was finally brought up on the political agenda with women’s entry in the engineering and ironworks industries. The conditions of labour shortage also placed a focus on other questions concerning the consequences of the protective labour legislation for women, like the prohibition against women’s night work and the question of women’s part-time work.The government had the opportunity to present new guidelines for women’s work at the end of the war. Instead a pattern was institutionalised that reinforced an image of women workers as a “latent labour reserve”. The propaganda picture of Mrs Loyal was forgotten, but in reality both married and unmarried women went on seeking solutions to the difficulties of combining wage work with children and housework.
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- Pejlare, Johanna, 1976
(författare)
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On Axioms and Images in the History of Mathematics
- 2007
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Doktorsavhandling (övrigt vetenskapligt/konstnärligt)abstract
- This dissertation deals with aspects of axiomatization, intuition and visualization in the history of mathematics. Particular focus is put on the end of the 19th century, before David Hilbert's (1862–1943) work on the axiomatization of Euclidean geometry. The thesis consists of three papers. In the first paper the Swedish mathematician Torsten Brodén (1857–1931) and his work on the foundations of Euclidean geometry from 1890 and 1912, is studied. A thorough analysis of his foundational work is made as well as an investigation into his general view on science and mathematics. Furthermore, his thoughts on geometry and its nature and what consequences his view has for how he proceeds in developing the axiomatic system, is studied. In the second paper different aspects of visualizations in mathematics are investigated. In particular, it is argued that the meaning of a visualization is not revealed by the visualization and that a visualization can be problematic to a person if this person, due to a limited knowledge or limited experience, has a simplified view of what the picture represents. A historical study considers the discussion on the role of intuition in mathematics which followed in the wake of Karl Weierstrass' (1815–1897) construction of a nowhere differentiable function in 1872. In the third paper certain aspects of the thinking of the two scientists Felix Klein (1849–1925) and Heinrich Hertz (1857–1894) are studied. It is investigated how Klein and Hertz related to the idea of naïve images and visual thinking shortly before the development of modern axiomatics. Klein in several of his writings emphasized his belief that intuition plays an important part in mathematics. Hertz argued that we form images in our mind when we experience the world, but these images may contain elements that do not exist in nature.
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- Repits, Johanna, et al.
(författare)
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Selection of human immunodeficiency virus type 1 R5 variants with augmented replicative capacity and reduced sensitivity to entry inhibitors during severe immunodeficiency.
- 2005
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Ingår i: Journal of General Virology. - : Microbiology Society. - 1465-2099 .- 0022-1317. ; 86:10, s. 2859-2869
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Tidskriftsartikel (refereegranskat)abstract
- Early in human immunodeficiency virus 1 (HIV-1) infection CCR5-using (R5) viruses predominate. With disease progression, approximately 50 % of infected individuals develop viruses able to use CXCR4. In the present work, the evolution of the biological properties of HIV-1 was studied in patients who retain viruses with an R5 phenotype despite AIDS onset. A panel of primary R5 HIV-1 isolates sequentially obtained at an asymptomatic stage and after AIDS diagnosis was examined. The viruses were selected based on our previous observation that R5 variants with reduced sensitivity to RANTES inhibition may appear during disease progression. Biological properties of the early and late R5 viruses, including infectivity, replicative capacity, impact of cationic polymer and sensitivity to inhibition by the entry inhibitors T-20 and TAK-779, were evaluated. R5 viruses isolated after AIDS onset displayed elevated replicative capacity and infectivity, and did not benefit from cationic polymer assistance during infection. Late R5 isolates also exhibited reduced sensitivity to inhibition by T-20 and TAK-779, even though the included patients were naïve to treatment with entry inhibitors and the isolates had not acquired mutations within the gp41 HR1 region. In addition, CD4+ T-cell counts at the time of R5 virus isolation correlated with infectivity, replicative capacity and sensitivity to inhibition by entry inhibitors. The results indicate that R5 HIV-1 variants with augmented replicative capacity and reduced sensitivity to entry inhibitors may be selected for during severe immunodeficiency. At a time when the clinical use of entry inhibitors is increasing, this observation could be of importance in the optimal design of such treatments.
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