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| 2. |
- Bjercke, Olav, et al.
(författare)
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Dental fear: A nnew treatment
- 1979
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Ingår i: Rapport från Avdelningen för Oral Diagnostik, Odontologiska kliniken, Göteborgs unniversitet. ; 2:2, s. 1-11
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Tidskriftsartikel (övrigt vetenskapligt/konstnärligt)
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| 3. |
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| 4. |
- Lindén, Anders, 1961, et al.
(författare)
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Behandling av patienter med grav tandvårdsrädsla
- 1979
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Ingår i: Rapport från Avdelningen för Oral Diagnostik, Odontologiska kliniken, Göteborgs unniversitet. ; 2:1, s. 1-16
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Tidskriftsartikel (övrigt vetenskapligt/konstnärligt)
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| 5. |
- Martinsson, Klara, et al.
(författare)
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Antibodies to leukotoxin A from the periodontal pathogen Aggregatibacter actinomycetemcomitans in patients at an increased risk of rheumatoid arthritis
- 2023
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Ingår i: Frontiers in Medicine. - : Frontiers Media S.A.. - 2296-858X. ; 10
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Tidskriftsartikel (refereegranskat)abstract
- Objectives: Periodontitis and underlying bacteria have been linked to the development of rheumatoid arthritis (RA). One suggested pathogen is Aggregatibacter actinomycetemcomitans (A.a.), which expresses leukotoxin A (LtxA) that can citrullinate human proteins, providing a possible trigger for the production of anti-citrullinated protein antibodies (ACPA). In this study, we seek to determine the presence of antibodies toward LtxA in patients at risk of developing RA.Methods: Two prospective observational patient cohorts (one Swedish and one British) with symptomatic at-risk patients were studied. Anti-LtxA antibodies were analyzed by a cell-based neutralization assay in baseline serum and compared to 100 Swedish blood donors that served as controls.Results: Serum anti-LtxA levels or positivity did not differ between patients and blood donors. In the British cohort, anti-LtxA was more prevalent among ACPA-positive arthralgia patients compared with ACPA-negative arthralgia cases (24% vs. 13%, p < 0.0001). In the Swedish at-risk cohort, anti-LtxA positive patients were at increased risk of progression to arthritis (hazard ratio (HR) 2.10, 95% CI 1.04–4.20), but this was not confirmed in the UK at-risk cohort (HR 0.99, CI 0.60–1.65).Conclusion: Serum anti-LtxA is not elevated before RA diagnosis, and associations with disease progression and ACPA levels differ between populations. Other features of the oral microbiome should be explored in upcoming periodontitis-related RA research.
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| 6. |
- Suopajärvi, Hannu, et al.
(författare)
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Use of biomass in integrated steelmaking – Status quo, future needs and comparison to other low-CO2 steel production technologies
- 2018
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Ingår i: Applied Energy. - : Elsevier BV. - 0306-2619 .- 1872-9118. ; 213, s. 384-407
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Tidskriftsartikel (refereegranskat)abstract
- This paper provides a fundamental and critical review of biomass application as a reducing agent and fuel in integrated steelmaking. The basis for the review is derived from the current process and product quality requirements that also biomass-derived fuels should fulfill. The availability and characteristics of different sources of biomass are discussed and suitable pretreatment technologies for their upgrading are evaluated. The existing literature concerning biomass application in bio-coke making, blast furnace injection, iron ore sintering and production of carbon composite agglomerates is reviewed and research gaps filled by providing insights and recommendations to the unresolved challenges. Several possibilities to integrate the production of biomass-based reducing agents with existing industrial infrastructures to lower the cost and increase the total efficiency are given. A comparison of technical challenges and CO2 emission reduction potential between biomass-based steelmaking and other emerging technologies to produce low-CO2 steel is made.
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| 7. |
- Svärd, Anna, et al.
(författare)
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Presence and immunoreactivity of Aggregatibacter actinomycetemcomitans in rheumatoid arthritis
- 2024
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Ingår i: Pathogens. - : MDPI. - 2076-0817. ; 13:5, s. 368-368
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Tidskriftsartikel (refereegranskat)abstract
- The presence of periodontal pathogens is associated with an increased prevalence of rheumatoid arthritis (RA). The systemic antibody response to epitopes of these bacteria is often used asa proxy to study correlations between bacteria and RA. The primary aim of the present study is toexamine the correlation between the presence of Aggregatibacter actinomycetemcomitans (Aa) in theoral cavity and serum antibodies against the leukotoxin (LtxA) produced by this bacterium. Thesalivary presence of Aa was analyzed with quantitative PCR and serum LtxA ab in a cell culturebased neutralization assay. The analyses were performed on samples from a well-characterized RAcohort (n = 189) and a reference population of blood donors (n = 101). Salivary Aa was present in15% of the RA patients and 6% of the blood donors. LtxA ab were detected in 19% of RA-sera andin 16% of sera from blood donors. The correlation between salivary Aa and serum LtxA ab wassurprisingly low (rho = 0.55 [95% CI: 0.40, 0.68]). The presence of salivary Aa showed no significantassociation with any of the RA-associated parameters documented in the cohort. A limitation of thepresent study is the relatively low number of individuals with detectable concentrations of Aa insaliva. Moreover, in the comparison of detectable Aa prevalence between RA patients and blooddonors, we assumed that the two groups were equivalent in other Aa prognostic factors. These limitations must be taken into consideration when the result from the study is interpreted. We concludethat a systemic immune response to Aa LtxA does not fully reflect the prevalence of Aa in saliva. Inaddition, the association between RA-associated parameters and the presence of Aa was negligiblein the present RA cohort.
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