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Träfflista för sökning "WFRF:(Önfelt Agneta) srt2:(2000-2004)"

Sökning: WFRF:(Önfelt Agneta) > (2000-2004)

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1.
  • Matsuoka, Atsuko, et al. (författare)
  • Correlation of sister chromatid exchange formation through homologous recombination with ribonucleotide reductase inhibition.
  • 2004
  • Ingår i: Mutat Res. - 0027-5107. ; 547:1-2, s. 101-7
  • Tidskriftsartikel (övrigt vetenskapligt/konstnärligt)abstract
    • We conducted the recombination and sister chromatid exchange (SCE) assays with five chemicals (hydroxyurea (HU), resveratrol, 4-hydroxy-trans-stilbene, 3-hydroxy-trans-stilbene, and mitomycin C) in Chinese hamster cell line SPD8/V79 to confirm directly that SCE is a result of homologous recombination (HR). SPD8 has a partial duplication in exon 7 of the endogenous hprt gene and can revert to wild type by homologous recombination. All chemicals were positive in both assays except for 3-hydroxy-trans-stilbene, which was negative in both. HU, resveratrol, and 4-hydroxy-trans-stilbene were scavengers of the tyrosyl free radical of the R2 subunit of mammalian ribonucleotide reductase. Tyrosyl free radical scavengers disturb normal DNA replication, causing replication fork arrest. Mitomycin C is a DNA cross-linking agent that also causes replication fork arrest. The present study suggests that replication fork arrest, which is similar to the early phases of HR, leads to a high frequency of recombination, resulting in SCEs. The findings show that SCE may be mediated by HR.
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