| 1. |
- Taal, H. Rob, et al.
(författare)
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Common variants at 12q15 and 12q24 are associated with infant head circumference
- 2012
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Ingår i: Nature Genetics. - : Springer Science and Business Media LLC. - 1061-4036 .- 1546-1718. ; 44:5, s. 532-538
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Tidskriftsartikel (refereegranskat)abstract
- To identify genetic variants associated with head circumference in infancy, we performed a meta-analysis of seven genome-wide association studies (GWAS) (N = 10,768 individuals of European ancestry enrolled in pregnancy and/or birth cohorts) and followed up three lead signals in six replication studies (combined N = 19,089). rs7980687 on chromosome 12q24 (P = 8.1 x 10(-9)) and rs1042725 on chromosome 12q15 (P = 2.8 x 10(-10)) were robustly associated with head circumference in infancy. Although these loci have previously been associated with adult height(1), their effects on infant head circumference were largely independent of height (P = 3.8 x 10(-7) for rs7980687 and P = 1.3 x 10(-7) for rs1042725 after adjustment for infant height). A third signal, rs11655470 on chromosome 17q21, showed suggestive evidence of association with head circumference (P = 3.9 x 10(-6)). SNPs correlated to the 17q21 signal have shown genome-wide association with adult intracranial volume(2), Parkinson's disease and other neurodegenerative diseases(3-5), indicating that a common genetic variant in this region might link early brain growth with neurological disease in later life.
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| 2. |
- Ikram, M. Arfan, et al.
(författare)
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Common variants at 6q22 and 17q21 are associated with intracranial volume
- 2012
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Ingår i: Nature Genetics. - : Springer Science and Business Media LLC. - 1061-4036 .- 1546-1718. ; 44:5, s. 539-544
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Tidskriftsartikel (refereegranskat)abstract
- During aging, intracranial volume remains unchanged and represents maximally attained brain size, while various interacting biological phenomena lead to brain volume loss. Consequently, intracranial volume and brain volume in late life reflect different genetic influences. Our genome-wide association study (GWAS) in 8,175 community-dwelling elderly persons did not reveal any associations at genome-wide significance (P < 5 x 10(-8)) for brain volume. In contrast, intracranial volume was significantly associated with two loci: rs4273712 (P = 3.4 x 10(-11)), a known height-associated locus on chromosome 6q22, and rs9915547 (P = 1.5 x 10(-12)), localized to the inversion on chromosome 17q21. We replicated the associations of these loci with intracranial volume in a separate sample of 1,752 elderly persons (P = 1.1 x 10(-3) for 6q22 and 1.2 x 10(-3) for 17q21). Furthermore, we also found suggestive associations of the 17q21 locus with head circumference in 10,768 children (mean age of 14.5 months). Our data identify two loci associated with head size, with the inversion at 17q21 also likely to be involved in attaining maximal brain size.
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| 3. |
- Haugen, H. A., et al.
(författare)
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CCS in the Skagerrak/Kattegat area
- 2011
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Ingår i: Energy Procedia. 10th International Conference on Greenhouse Gas Control Technologies; Amsterdam; 19-23 September 2010. - : Elsevier BV. - 1876-6102. ; 4, s. 2324-2331
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Konferensbidrag (refereegranskat)abstract
- This paper presents an ongoing project with the aim to assess a CO 2 infrastructure in the Skagerrak/Kattegat region (the sea bordered by north of Denmark, south coast of Norway and the west coast of Sweden). The area comprises 10-12 CO2 emission sources of more than 0.5 Mt/year. The geological and geophysical assessment of CO2 storage potential in the described area as well as reservoir modelling and simulations are performed in work package (WP) 1. The results from WP1 are used in the other work packages. Candidate storage sites are matched with those point sources in the region that are technically and economically feasible for CO2 capture, together with an assessment of the connecting infrastructure needs. WP 2 focuses on identifying optimal technological CO2 infrastructure solutions. Sources-to-sink solutions are in the process of being developed based on input from WP1 and WP3. Assessment of the build-up of a complete CCS infrastructure from a system perspective is the overall focus of WP 3, covering economical, practical and judicial aspects. The project group explores the economic potential for capture at each individual site including looking at other CO2 mitigation options and propose relevant capture technology with cost estimations. Dissemination of project results is organized in a separate work package, WP4.
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| 4. |
- Haugen, H.A., et al.
(författare)
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Infrastructure for CCS in the Skagerrak/Kattegat region, Southern Scandinavia: A feasibility study
- 2013
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Ingår i: Energy Procedia. - : Elsevier BV. - 1876-6102. ; 37, s. 2562-2569
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Konferensbidrag (refereegranskat)abstract
- This paper gives an overview of results from a project which explored the feasibility of establishing a CO2 Capture and Storage infrastructure in the Skagerrak/Kattegat region of Southern Scandinavia. This involves assessment of the technical and economic parameters of the complete CCS chain and, in particular, identification of possible storage locations. The project ran from June 2009 to December 2011. Emissions from three major industrial clusters in the Skagerrak/Kattegat region - Gothenburg in Sweden, Grenland in Telemark County, southern Norway and Aalborg in Denmark - were targeted. Both emissions from process industries as well as power plants were included.
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| 5. |
- Helge, E. W., et al.
(författare)
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Recreational football training decreases risk factors for bone fractures in untrained premenopausal women
- 2010
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Ingår i: Scandinavian Journal of Medicine & Science in Sports. - : Wiley. - 1600-0838 .- 0905-7188. ; 20:s1, s. 31-39
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Tidskriftsartikel (refereegranskat)abstract
- The present intervention was designed to investigate whether a 14-week period of regular recreational association football (F) or endurance running (R) has an effect on the risk of falls and bone fractures due to gains in muscle function and volumetric bone mineral density (vBMD). Fifty healthy untrained Danish premenopausal women were randomized into two training groups (F and R) that trained 1.8 +/- 0.3 (+/- SD) and 1.9 +/- 0.3 h/week, respectively, and these groups were compared with an inactive control group (C). Jumping and dynamic muscle strength were tested and tibial vBMD was measured using peripheral quantitative computed tomography. Total vBMD in left and right tibia increased by 2.6 +/- 2.3% and 2.1 +/- 1.8% (P < 0.005), respectively, in F and by 0.7 +/- 1.3% (P=0.05) and 1.1 +/- 1.5% (P < 0.01), respectively, in R without any significant changes in C. Similar results were found for trabecular vBMD. In F, peak jump power increased by 3 +/- 6% (P < 0.05), and hamstring strength during fast (240 degrees/s) and slow (30 degrees/s) contractions increased by 11 +/- 25% and 9 +/- 21%, respectively, (P < 0.05) without any significant changes in R or C. In conclusion, 14 weeks of regular recreational football improved peak jump power, maximal hamstring strength and vBMD in the distal tibia, suggesting a decreased fracture risk due to stronger bones and a reduced risk of falling.
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