| 1. |
- Pattaro, Cristian, et al.
(författare)
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Genetic associations at 53 loci highlight cell types and biological pathways relevant for kidney function
- 2016
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Ingår i: Nature Communications. - : Springer Science and Business Media LLC. - 2041-1723. ; 7
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Tidskriftsartikel (refereegranskat)abstract
- Reduced glomerular filtration rate defines chronic kidney disease and is associated with cardiovascular and all-cause mortality. We conducted a meta-analysis of genome-wide association studies for estimated glomerular filtration rate (eGFR), combining data across 133,413 individuals with replication in up to 42,166 individuals. We identify 24 new and confirm 29 previously identified loci. Of these 53 loci, 19 associate with eGFR among individuals with diabetes. Using bioinformatics, we show that identified genes at eGFR loci are enriched for expression in kidney tissues and in pathways relevant for kidney development and transmembrane transporter activity, kidney structure, and regulation of glucose metabolism. Chromatin state mapping and DNase I hypersensitivity analyses across adult tissues demonstrate preferential mapping of associated variants to regulatory regions in kidney but not extra-renal tissues. These findings suggest that genetic determinants of eGFR are mediated largely through direct effects within the kidney and highlight important cell types and biological pathways.
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| 2. |
- Baldi, R. D., et al.
(författare)
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LeMMINGs - I. The eMERLIN legacy survey of nearby galaxies. 1.5-GHz parsec-scale radio structures and cores
- 2018
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Ingår i: Monthly Notices of the Royal Astronomical Society. - 0035-8711 .- 1365-2966. ; 476:3, s. 3478-3522
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Tidskriftsartikel (refereegranskat)abstract
- We present the first data release of high-resolution (≤0.2 arcsec) 1.5-GHz radio images of 103 nearby galaxies from the Palomar sample, observed with the eMERLIN array, as part of the LeMMINGs survey. This sample includes galaxies which are active (low-ionization nuclear emission-line regions [LINER] and Seyfert) and quiescent (H II galaxies and absorption line galaxies, ALGs), which are reclassified based upon revised emission-line diagrams.We detect radio emission ≳0.2 mJy for 47/103 galaxies (22/34 for LINERS, 4/4 for Seyferts, 16/51 for HII galaxies, and 5/14 for ALGs) with radio sizes typically of ≲100 pc. We identify the radio core position within the radio structures for 41 sources. Half of the sample shows jetted morphologies. The remaining half shows single radio cores or complex morphologies. LINERs show radio structures more core-brightened than Seyferts. Radio luminosities of the sample range from 1032to 1040erg s-1: LINERs and HII galaxies show the highest and lowest radio powers, respectively, while ALGs and Seyferts have intermediate luminosities. We find that radio core luminosities correlate with black hole (BH) mass down to ~107M⊙, but a break emerges at lower masses. Using [OIII] line luminosity as a proxy for the accretion luminosity, active nuclei and jetted HII galaxies follow an optical Fundamental Plane of BH activity, suggesting a common disc-jet relationship. In conclusion, LINER nuclei are the scaled-down version of FR I radio galaxies; Seyferts show less collimated jets; HII galaxies may host weak active BHs and/or nuclear star-forming cores; and recurrent BH activity may account for ALG properties.
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| 3. |
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| 4. |
- McCoy, M., et al.
(författare)
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ALMA Observations of the Physical and Chemical Conditions in Centaurus A
- 2017
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Ingår i: Astrophysical Journal. - : American Astronomical Society. - 1538-4357 .- 0004-637X. ; 851:2
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Tidskriftsartikel (refereegranskat)abstract
- Centaurus A, with its gas-rich elliptical host galaxy, NGC 5128, is the nearest radio galaxy at a distance of 3.8 Mpc. Its proximity allows us to study the interaction among an active galactic nucleus, radio jets, and molecular gas in great detail. We present ALMA observations of low-J transitions of three CO isotopologues, HCN, HCO+, HNC, CN, and CCH toward the inner projected 500 pc of NGC 5128. Our observations resolve physical sizes down to 40 pc. By observing multiple chemical probes, we determine the physical and chemical conditions of the nuclear interstellar medium of NGC 5128. This region contains molecular arms associated with the dust lanes and a circumnuclear disk (CND) interior to the molecular arms. The CND is approximately 400 pc by 200 pc and appears to be chemically distinct from the molecular arms. It is dominated by dense gas tracers while the molecular arms are dominated by (CO)-C-12 and its rare isotopologues. The CND has a higher temperature, elevated CN/HCN and HCN/HNC intensity ratios, and much weaker (CO)-C-13 and (CO)-O-18 emission than the molecular arms. This suggests an influence from the AGN on the CND molecular gas. There is also absorption against the AGN with a low velocity complex near the systemic velocity and a high velocity complex shifted by about 60 km s(-1). We find similar chemical properties between the CND in emission and both the low and high velocity absorption complexes, implying that both likely originate from the CND. If the HV complex does originate in the CND, then that gas would correspond to gas falling toward the supermassive black hole.
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| 5. |
- Rosenberg, M. J. F., et al.
(författare)
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The Herschel Comprehensive (U)lirg Emission Survey (Hercules): Co Ladders, Fine Structure Lines, and Neutral Gas Cooling
- 2015
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Ingår i: Astrophysical Journal. - : American Astronomical Society. - 1538-4357 .- 0004-637X. ; 801:2
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Tidskriftsartikel (refereegranskat)abstract
- (Ultra) luminous infrared galaxies ((U)LIRGs) are objects characterized by their extreme infrared (8-1000 mu m) luminosities (L-LIRG > 10(11) L-circle dot and L-ULIRG > 10(12) L-circle dot). The Herschel Comprehensive ULIRG Emission Survey (PI: van derWerf) presents a representative flux-limited sample of 29 (U)LIRGs that spans the full luminosity range of these objects (10(11)L(circle dot)
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| 6. |
- Boquien, M., et al.
(författare)
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Measuring star formation with resolved observations: the test case of M 33
- 2015
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Ingår i: Astronomy and Astrophysics. - : EDP Sciences. - 0004-6361 .- 1432-0746. ; 578
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Tidskriftsartikel (refereegranskat)abstract
- Context. Measuring star formation on a local scale is important to constrain star formation laws. It is not clear yet, however, whether and how the measure of star formation is affected by the spatial scale at which a galaxy is observed. Aims. We wish to understand the impact of the resolution on the determination of the spatially resolved star formation rate (SFR) and other directly associated physical parameters such as the attenuation. Methods. We carried out a multi-scale, pixel-by-pixel study of the nearby galaxy M33. Assembling FUV, H alpha, 8 mu m, 24 mu m, 70 mu m, and 100 mu m maps, we have systematically compared the emission in individual bands with various SFR estimators from a resolution of 33 pc to 2084 pc. Results. There are strong, scale-dependent, discrepancies of up to a factor 3 between monochromatic SFR estimators and H alpha + 24 mu m. The scaling factors between individual IR bands and the SFR show a strong dependence on the spatial scale and on the intensity of star formation. Finally, strong variations of the differential reddening between the nebular emission and the stellar continuum are seen, depending on the specific SFR (sSFR) and on the resolution. At the finest spatial scales, there is little differential reddening at high sSFR. The differential reddening increases with decreasing sSFR. At the coarsest spatial scales the differential reddening is compatible with the canonical value found for starburst galaxies. Conclusions. Our results confirm that monochromatic estimators of the SFR are unreliable at scales smaller than 1 kpc. Furthermore, the extension of local calibrations to high-redshift galaxies presents non-trivial challenges because the properties of these systems may be poorly known.
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| 7. |
- Burillo, S. G., et al.
(författare)
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ALMA imaging of C2H emission in the disk of NGC 1068
- 2017
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Ingår i: Astronomy and Astrophysics. - : EDP Sciences. - 0004-6361 .- 1432-0746. ; 608, s. A56-
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Tidskriftsartikel (refereegranskat)abstract
- Aims. We study the feedback of star formation and nuclear activity on the chemistry of molecular gas in NGC 1068, a nearby (D = 14 Mpc) Seyfert 2 barred galaxy, by analyzing whether the abundances of key molecular species such as ethynyl (C2H), which is a classical tracer of photon dominated regions (PDR), change in the different environments of the disk of the galaxy. Methods. We used the Atacama Large Millimeter Array (ALMA) to map the emission of the hyperfine multiplet of C2H(N = 1-0) and its underlying continuum emission in the central r similar or equal to 35" (2.5 kpc) region of the disk of NGC 1068 with a spatial resolution 1.0 x 0.7 (similar or equal to 50-70 pc). We used maps of the dust continuum emission obtained at 349 GHz by ALMA to derive the H-2 gas column densities and combined these with the C2H map at matched spatial resolution to estimate the fractional abundance of this species. We developed a set of time-dependent chemical models, which include shocks, gas-phase PDRs, and gas-grain chemical models to determine the origin of the C2H gas. Results. A sizeable fraction of the total C2H line emission is detected from the r similar or equal to 1.3 kpc starburst (SB) ring, which is a region that concentrates the bulk of the recent massive star formation in the disk traced by the Pa alpha emission complexes imaged by the Hubble Space Telescope (HST). However, the brightest C2H emission originates from a r similar or equal to 200 pc off -centered circumnuclear disk (CND), where evidence of a molecular outflow has been previously found in other molecular tracers imaged by ALMA. We also detect significant emission that connects the CND with the outer disk in a region that probes the interface between the molecular disk and ionized gas outflow out to r similar or equal to 400 pc. We derived the fractional abundances of C2H (X(C2H)) assuming local thermodynamic equilibrium (LTE) conditions and a set of excitation temperatures (T-ex) constrained by the previous multiline CO studies of the galaxy. Our estimates range from X(C2H) similar or equal to a few 10(-8) in the SB ring up to X(C2H) similar or equal to a few 10(-7) in the outflow region. The PDR models that incorporate gas-grain chemistry are able to account for X(C2H) in the SB ring for moderately dense (n(H-2) >= 10(4) cm(-3)) and moderately UV-irradiated gas (UV-field = 10(4-5) cm(-3)). Conclusions. We find that the transient conditions required to fit the high values of X(C2H) in the outflow are likely due to UV or X-ray irradiated non-dissociative shocks associated with the highly turbulent interface between the outflow and molecular gas in NGC 1068. Although the inferred local timescales are short, the erosion of molecular clouds by the active galactic nucleus (AGN) wind and/or the jet likely resupplies the interface working surface continuously, making a nearly steady state persist in the disk of the galaxy.
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| 8. |
- Burillo, S. G., et al.
(författare)
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ALMA resolves the torus of NGC 1068: Continuum and molecular line emission
- 2016
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Ingår i: Astrophysical Journal Letters. - : American Astronomical Society. - 2041-8213 .- 2041-8205. ; 823:1, s. Art. no. L12-
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Tidskriftsartikel (refereegranskat)abstract
- We used the Atacama Large Millimeter Array (ALMA) to map the emission of the CO(6-5) molecular line and the 432 mu m continuum emission from the 300 pc sized circumnuclear disk (CND) of the nearby Seyfert 2 galaxy NGC 1068 with a spatial resolution of similar to 4 pc. These observations spatially resolve the CND and, for the first time, image the dust emission, the molecular gas distribution, and the kinematics from a 7-10 pc diameter disk that represents the submillimeter counterpart of the putative torus of NGC 1068. We fitted the nuclear spectral energy distribution of the torus using ALMA and near-and mid-infrared (NIR/MIR) data with CLUMPY torus models. The mass and radius of the best-fit solution for the torus are both consistent with the values derived from the ALMA data alone: M-gas(torus) = (1 +/- 0.3) x 10(5) M-circle dot and R-torus = 3.5 +/- 0.5 pc. The dynamics of the molecular gas in the torus show strong non-circular motions and enhanced turbulence superposed on a surprisingly slow rotation pattern of the disk. By contrast with the nearly edge-on orientation of the H2O megamaser disk, we found evidence suggesting that the molecular torus is less inclined (i = 34 degrees-66 degrees) at larger radii. The lopsided morphology and complex kinematics of the torus could be the signature of the Papaloizou-Pringle instability, long predicted to likely drive the dynamical evolution of active galactic nuclei tori.
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| 9. |
- Burillo, S. G., et al.
(författare)
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High-resolution imaging of the molecular outflows in two mergers: IRAS 17208-0014 and NGC 1614
- 2015
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Ingår i: Astronomy and Astrophysics. - : EDP Sciences. - 0004-6361 .- 1432-0746. ; 580
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Tidskriftsartikel (refereegranskat)abstract
- Context. Galaxy evolution scenarios predict that the feedback of star formation and nuclear activity (AGN) can drive the transformation of gas-rich spiral mergers into (ultra) luminous infrared galaxies and, eventually, lead to the build-up of QSO/elliptical hosts. Aims. We study the role that star formation and AGN feedback have in launching and maintaining the molecular outflows in two starburst-dominated advanced mergers, NGC 1614 (DL = 66 Mpc) and IRAS 17208-0014 (DL = 181 Mpc), by analyzing the distribution and kinematics of their molecular gas reservoirs. Both galaxies present evidence of outflows in other phases of their ISM. Methods. We used the Plateau de Bure interferometer (PdBI) to image the CO(10) and CO(21) line emissions in NGC 1614 and IRAS 17208-0014, respectively, with high spatial resolution (0: 0051: 002). The velocity fields of the gas were analyzed and modeled to find the evidence of molecular outflows in these sources and characterize the mass, momentum, and energy of these components. Results. While most (95%) of the CO emission stems from spatially resolved (23 kpc-diameter) rotating disks, we also detect in both mergers the emission from high-velocity line wings that extend up to -500-700 km s1, well beyond the estimated virial range associated with rotation and turbulence. The kinematic major axis of the line-wing emission is tilted by 90 in NGC 1614 and by 180 in IRAS 17208-0014 relative to the major axes of their respective rotating disks. These results can be explained by the existence of non-coplanar molecular outflows in both systems: the outflow axis is nearly perpendicular to the rotating disk in NGC 1614, but it is tilted relative to the angular momentum axis of the rotating disk in IRAS 17208-0014. Conclusions. In stark contrast to NGC 1614, where star formation alone can drive its molecular outflow, the mass, energy, and momentum budget requirements of the molecular outflow in IRAS 17208-0014 can be best accounted for by the existence of a so far undetected (hidden) AGN of LAGN71011 L The geometry of the molecular outflow in IRAS 17208-0014 suggests that the outflow is launched by a non-coplanar disk that may be associated with a buried AGN in the western nucleus.
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| 10. |
- Falstad, Niklas, 1987, et al.
(författare)
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Herschel spectroscopic observations of the compact obscured nucleus in Zw 049.057
- 2015
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Ingår i: Astronomy and Astrophysics. - : EDP Sciences. - 0004-6361 .- 1432-0746. ; 580, s. A52-
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Tidskriftsartikel (refereegranskat)abstract
- Context. The luminous infrared galaxy Zw 049.057 contains a compact obscured nucleus where a considerable amount of the galaxy's luminosity is generated. This nucleus contains a dusty environment that is rich in molecular gas. One approach to probing this kind of environment and to revealing what is hidden behind the dust is to study the rotational lines of molecules that couple well with the infrared radiation emitted by the dust. Aims. We probe the physical conditions in the core of Zw 049.057 and establish the nature of its nuclear power source (starburst or active galactic nucleus). Methods. We observed Zw 049.057 with the Photodetector Array Camera and Spectrometer (PACS) and the Spectral and Photometric Imaging Receiver (SPIRE) onboard the Herschel Space Observatory in rotational lines of H2O, H218O, OH, 18OH, and [O I]. We modeled the unresolved core of the galaxy using a spherically symmetric radiative transfer code. To account for the different excitation requirements of the various molecular transitions, we use multiple components and different physical conditions. Results. We present the full high-resolution SPIRE FTS spectrum of Zw 049.057, along with relevant spectral scans in the PACS range. We find that a minimum of two different components (nuclear and extended) are required in order to account for the rich molecular line spectrum of Zw 049.057. The nuclear component has a radius of 10-30 pc, a very high infrared surface brightness (∼1014L⊙kpc-2), warm dust (Td > 100 K), and a very large H2 column density (NH2 = 1024-1025 cm-2). The modeling also indicates high nuclear H2O (∼5 × 10-6) and OH (∼4 × 10-6) abundances relative to H2 as well as a low 16O/18O-ratio of 50-100. We also find a prominent infall signature in the [O I] line. We tentatively detect a 500 km s-1 outflow in the H2O 313 → 202 line. Conclusions. The high surface brightness of the core indicates the presence of either a buried active galactic nucleus or a very dense nuclear starburst. The estimated column density towards the core of Zw 049.057 indicates that it is Compton-thick, making a buried X-ray source difficult to detect even in hard X-rays. We discuss the elevated H2O abundance in the nucleus in the context of warm grain and gas-phase chemistry. The H2O abundance is comparable to that of other compact (ultra-)luminous infrared galaxies such as NGC 4418 and Arp 220 - and also to hot cores in the Milky Way. The enhancement of 18O is a possible indicator that the nucleus of Zw 049.057 is in a similar evolutionary stage as the nuclei of Arp 220 - and more advanced than NGC 4418. We discuss the origin of the extreme nuclear gas concentration and note that the infalling gas detected in [O I] implies that the gas reservoir in the central region of Zw 049.057 is being replenished. If confirmed, the H2O outflow suggests that the nucleus is in a stage of rapid evolution.
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