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Bioelectronic Direc...
Bioelectronic Direct Current Stimulation at the Transition Between Reversible and Irreversible Charge Transfer
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- Matter, Lukas, 1995 (författare)
- Department of Microtechnology and Nanoscience, Chalmers University of Technology, Gothenburg, SE 41296 Sweden; Department of Microsystems Engineering, University of Freiburg, Georges-Köhler-Allee 201, 79110 Freiburg, Germany; Brainlinks-Braintools Center, University of Freiburg, Georges-Köhler-Allee 201, 79110 Freiburg, Germany; Freiburg Institute for Advanced Studies (FRIAS), University of Freiburg, Albertstraße 19, 79104 Freiburg, Germany,Albert-Ludwigs-Universität Freiburg,University of Freiburg,Chalmers tekniska högskola,Chalmers University of Technology
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- Abdullaeva, Oliya S. (författare)
- Luleå tekniska universitet,Omvårdnad och medicinsk teknik,Luleå tekniska universitet (LTU),Luleå University of Technology (LTU)
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- Shaner, Sebastian (författare)
- Department of Microsystems Engineering, University of Freiburg, Georges-Köhler-Allee 201, 79110 Freiburg, Germany; Brainlinks-Braintools Center, University of Freiburg, Georges-Köhler-Allee 201, 79110 Freiburg, Germany,Albert-Ludwigs-Universität Freiburg,University of Freiburg
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- Leal, José (författare)
- Department of Microsystems Engineering, University of Freiburg, Georges-Köhler-Allee 201, 79110 Freiburg, Germany; Brainlinks-Braintools Center, University of Freiburg, Georges-Köhler-Allee 201, 79110 Freiburg, Germany,Albert-Ludwigs-Universität Freiburg,University of Freiburg
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- Asplund, Maria (författare)
- Luleå tekniska universitet,Omvårdnad och medicinsk teknik,Department of Microtechnology and Nanoscience, Chalmers University of Technology, Gothenburg, SE 41296 Sweden; Department of Microsystems Engineering, University of Freiburg, Georges-Köhler-Allee 201, 79110 Freiburg, Germany; Brainlinks-Braintools Center, University of Freiburg, Georges-Köhler-Allee 201, 79110 Freiburg, Germany; Freiburg Institute for Advanced Studies (FRIAS), University of Freiburg, Albertstraße 19, 79104 Freiburg, Germany,Albert-Ludwigs-Universität Freiburg,University of Freiburg,Luleå tekniska universitet (LTU),Luleå University of Technology (LTU),Chalmers tekniska högskola,Chalmers University of Technology
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(creator_code:org_t)
- John Wiley & Sons, 2024
- 2024
- Engelska.
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Ingår i: Advanced Science. - : John Wiley & Sons. - 2198-3844. ; 11:27
- Relaterad länk:
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https://doi.org/10.1...
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https://ltu.diva-por... (primary) (Raw object)
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https://urn.kb.se/re...
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https://doi.org/10.1...
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https://research.cha...
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Abstract
Ämnesord
Stäng
- Many biological processes rely on endogenous electric fields (EFs), including tissue regeneration, cell development, wound healing, and cancer metastasis. Mimicking these biological EFs by applying external direct current stimulation (DCS) is therefore the key to many new therapeutic strategies. During DCS, the charge transfer from electrode to tissue relies on a combination of reversible and irreversible electrochemical processes, which may generate toxic or bio-altering substances, including metal ions and reactive oxygen species (ROS). Poly(3,4-ethylenedioxythiophene) (PEDOT) based electrodes are emerging as suitable candidates for DCS to improve biocompatibility compared to metals. This work addresses whether PEDOT electrodes can be tailored to favor reversible biocompatible charge transfer. To this end, different PEDOT formulations and their respective back electrodes are studied using cyclic voltammetry, chronopotentiometry, and direct measurements of H2O2 and O2. This combination of electrochemical methods sheds light on the time dynamics of reversible and irreversible charge transfer and the relationship between capacitance and ROS generation. The results presented here show that although all electrode materials investigated generate ROS, the onset of ROS can be delayed by increasing the electrode's capacitance via PEDOT coating, which has implications for future bioelectronic devices that allow longer reversibly driven pulse durations during DCS.
Ämnesord
- TEKNIK OCH TEKNOLOGIER -- Industriell bioteknik -- Medicinsk bioteknik (hsv//swe)
- ENGINEERING AND TECHNOLOGY -- Industrial Biotechnology -- Medical Biotechnology (hsv//eng)
- NATURVETENSKAP -- Kemi (hsv//swe)
- NATURAL SCIENCES -- Chemical Sciences (hsv//eng)
Nyckelord
- capacitance estimation
- charge transfer mechanisms
- direct current electric fields
- reactive oxygen species
- Medical Engineering
- Medicinsk teknik
Publikations- och innehållstyp
- ref (ämneskategori)
- art (ämneskategori)
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