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A Swedish study of ...
A Swedish study of chemoradiation in squamous cell carcinoma of the esophagus
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- Stockeld, Dag (author)
- Karolinska Institutet
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- Tennvall, Jan (author)
- Lund University,Lunds universitet,Bröstcancer-genetik,Sektion I,Institutionen för kliniska vetenskaper, Lund,Medicinska fakulteten,Breastcancer-genetics,Section I,Department of Clinical Sciences, Lund,Faculty of Medicine
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- Wagenius, Gunnar (author)
- Uppsala universitet,Institutionen för onkologi, radiologi och klinisk immunologi
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- Albertsson, Maria (author)
- Lund University,Lunds universitet,Bröstcancer-genetik,Sektion I,Institutionen för kliniska vetenskaper, Lund,Medicinska fakulteten,Breastcancer-genetics,Section I,Department of Clinical Sciences, Lund,Faculty of Medicine
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Backman, Lars (author)
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- Brodin, Ola (author)
- Uppsala universitet,Karolinska Institutet,Institutionen för onkologi, radiologi och klinisk immunologi
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- Cwikiel, Magdalena (author)
- Lund University,Lunds universitet,Bröstcancer-genetik,Sektion I,Institutionen för kliniska vetenskaper, Lund,Medicinska fakulteten,Breastcancer-genetics,Section I,Department of Clinical Sciences, Lund,Faculty of Medicine
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- Granstrom, Lars (author)
- Karolinska Institutet
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Gustafsson, Gunnar (author)
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Gustavsson, Sven (author)
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Hambraeus, Göran (author)
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- Lewensohn, Rolf (author)
- Karolinska Institutet
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Sjöstedt, Svante (author)
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Strander, Hans (author)
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Aberg, Bengt (author)
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Fagerberg, Jan (author)
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(creator_code:org_t)
- 2010-06-09
- 2001
- English.
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In: Acta Oncologica. - : Informa UK Limited. - 1651-226X .- 0284-186X. ; 40, s. 566-
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Abstract
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- This multicenter study describes the development of a chemoradiation protocol for the treatment of non-metastatic squamous cell carcinoma of the esophagus. Eighty patients were treated with three courses of chemotherapy (cisplatinum and 5-fluorouracil) with concomitant radiotherapy (40 Gy) during the last two courses of chemotherapy. Esophagectomy was performed, when feasible. If no operation was performed, patients were planned to receive a target dose of 64 Gy. Toxicity was mainly attributable to hematological impairment and led to two adjustments of the treatment protocol (addition of filgrastim and lowering of the 5-fluorouracil dose). These changes made it possible to administer the planned treatment in a gradually higher proportion of patients (13/23 [57%] before changes of treatment compared with 30/36 [83%] after changes). Treatment-related mortality was 3.75% (3 patients, associated with leucopenic septicemia after chemotherapy). Fifty-four patients were resected. No per- or postoperative mortality was encountered. The complete response (pathological CR) rate in operated patients was 46% (27/59 patients) after chemoradiation. In the whole series the CR rate (including clinical CR for non-resected patients) was 44%. With a minimum follow-up of 37 months, the 3-year survival for the whole group was 31% compared with 57% for the CR patients. Total 5-year survival thus far (July 1999) is 26%.
Subject headings
- MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin -- Cancer och onkologi (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Clinical Medicine -- Cancer and Oncology (hsv//eng)
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- art (subject category)
- ref (subject category)
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- By the author/editor
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Stockeld, Dag
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Tennvall, Jan
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Wagenius, Gunnar
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Albertsson, Mari ...
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Backman, Lars
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Brodin, Ola
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Cwikiel, Magdale ...
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Granstrom, Lars
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Gustafsson, Gunn ...
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Gustavsson, Sven
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Hambraeus, Göran
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Lewensohn, Rolf
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Sjöstedt, Svante
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Strander, Hans
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Aberg, Bengt
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Fagerberg, Jan
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- About the subject
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- MEDICAL AND HEALTH SCIENCES
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MEDICAL AND HEAL ...
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and Clinical Medicin ...
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and Cancer and Oncol ...
- Articles in the publication
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Acta Oncologica
- Acta Oncol.
- By the university
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Lund University
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Karolinska Institutet
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Uppsala University