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Dietary intakes of dioxins and polychlorobiphenyls (PCBs) and mortality : EPIC cohort study in 9 European countries
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- Fiolet, Thibault (författare)
- European Food Safety Authority,Versailles Saint-Quentin-en-Yvelines University
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- Nicolas, Geneviève (författare)
- International Agency for Research on Cancer, World Health Organization
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- Casagrande, Corinne (författare)
- International Agency for Research on Cancer, World Health Organization
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- Horvath, Zsuzsanna (författare)
- European Food Safety Authority
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- Frenoy, Pauline (författare)
- Versailles Saint-Quentin-en-Yvelines University
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- Weiderpass, Elisabete (författare)
- International Agency for Research on Cancer, World Health Organization
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- Gunter, Marc J. (författare)
- International Agency for Research on Cancer, World Health Organization
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- Manjer, Jonas (författare)
- Lund University,Lunds universitet,Kirurgi,Forskargrupper vid Lunds universitet,Surgery,Lund University Research Groups,Skåne University Hospital
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- Sonestedt, Emily (författare)
- Lund University,Lunds universitet,Nutritionsepidemiologi,Forskargrupper vid Lunds universitet,Nutrition Epidemiology,Lund University Research Groups
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- Palli, Domenico (författare)
- Institute for Cancer Research, Prevention and Clinical Network (ISPRO)
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Simeon, Vittorio (författare)
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- Tumino, Rosario (författare)
- Hyblean Association for Epidemiological Research
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- Bueno-de-Mesquita, Bas (författare)
- National Institute for Public Health and the Environment (RIVM)
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- Huerta, José María (författare)
- Murcia Regional Health Council,CIBER Epidemiology and Public Health (CIBERESP)
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- Rodriguez-Barranco, Miguel (författare)
- CIBER Epidemiology and Public Health (CIBERESP),Andalusian School Of Public Health (EASP)
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- Abilleira, Eunate (författare)
- Ministry of Health of the Basque Government,Biodonostia Health Research Institute
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- Sacerdote, Carlotta (författare)
- Citta' della Salute e della Scienza Hospital-University of Turin
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- Schulze, Matthias B. (författare)
- University of Potsdam,German Institute of Human Nutrition
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- Heath, Alicia K. (författare)
- Imperial College London
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- Rylander, Charlotta (författare)
- UiT The Arctic University of Norway, Tromsø
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- Skeie, Guri (författare)
- UiT The Arctic University of Norway, Tromsø
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- Nøst, Therese Haugdahl (författare)
- UiT The Arctic University of Norway, Tromsø
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- Tjønneland, Anne (författare)
- Danish Cancer Society,University of Copenhagen
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- Olsen, Anja (författare)
- Danish Cancer Society,Aarhus University
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- Pala, Valeria (författare)
- Istituto Nazionale dei Tumori
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- Kvaskoff, Marina (författare)
- Versailles Saint-Quentin-en-Yvelines University
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- Huybrechts, Inge (författare)
- International Agency for Research on Cancer, World Health Organization
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- Mancini, Francesca Romana (författare)
- Versailles Saint-Quentin-en-Yvelines University
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(creator_code:org_t)
- 2024
- 2024
- Engelska.
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Ingår i: International Journal of Hygiene and Environmental Health. - 1438-4639. ; 255
- Relaterad länk:
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http://dx.doi.org/10...
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https://lup.lub.lu.s...
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https://doi.org/10.1...
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Abstract
Ämnesord
Stäng
- Dioxins and polychlorinated biphenyls (PCBs) are toxic, endocrine disruptors and persistent chemicals for which the main exposure source is diet due to their bioaccumulation and biomagnification in food chains. Cohort studies in the general populations have reported inconsistent associations between these chemicals in serum/plasma and mortality. Our objective was to study the association between dietary intake of 17 dioxins and 35 PCBs and all-cause, cancer-specific and cardiovascular-specific mortalities were assessed in the European Prospective Investigation into Cancer and Nutrition (EPIC) cohort. Dietary intake of dioxins and PCBs was assessed combining EPIC food consumption data with European food contamination data provided by the European Food Safety Authority. We applied multivariable Cox regressions. The analysis included 451,390 adults (mean ± SD age:51.1 ± 9.7 years) with 46,627 deaths and a median follow-up of 17.4 years (IQR = 15.2–19.1). A U-shaped non-linear association with all-cause mortality for dietary intake of dioxins (Pnon-linearity<0.0001), DL-PCB (Pnon-linearity = 0.0001), and NDL-PCBs (Pnon-linearity<0.01) was observed. For example, the hazard ratios (95%Confidance interval) for all-cause mortality obtained with the spline model was equal to 1.03 (1.02–1.05) for low levels of intake to dioxins (7 pg TEQ/day), 0.93 (0.90–0.96) for moderate levels of intake (25 pg TEQ/day), while for high levels of intake (55 pg TEQ/day) it was 1.03 (0.97–1.09). Intake of dioxins, DL-PCBs and NDL-PCBs was not associated with cardiovascular mortality. There was no association between intakes of dioxins and cancer mortality, but a U-shaped association was observed for intake of DL-PCBs and intakes of NDL-PCBs and cancer mortality. The PCBs and dioxins are known to have endocrine disrupting properties which can lead to non-monotonic dose responses. These results need to be interpreted with caution and further studies are needed to better clarify the association between dietary intake of dioxins and PCB and mortality in the general population.
Ämnesord
- MEDICIN OCH HÄLSOVETENSKAP -- Hälsovetenskap -- Näringslära (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Health Sciences -- Nutrition and Dietetics (hsv//eng)
Nyckelord
- Deaths
- Dioxins
- Food contaminants
- Mortality
- Persistent organic pollutants
- Polychlorinated biphenyls
Publikations- och innehållstyp
- art (ämneskategori)
- ref (ämneskategori)
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- Av författaren/redakt...
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Fiolet, Thibault
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Nicolas, Geneviè ...
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Casagrande, Cori ...
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Horvath, Zsuzsan ...
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Frenoy, Pauline
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Weiderpass, Elis ...
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visa fler...
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Gunter, Marc J.
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Manjer, Jonas
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Sonestedt, Emily
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Palli, Domenico
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Simeon, Vittorio
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Tumino, Rosario
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Bueno-de-Mesquit ...
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Huerta, José Mar ...
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Rodriguez-Barran ...
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Abilleira, Eunat ...
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Sacerdote, Carlo ...
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Schulze, Matthia ...
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Heath, Alicia K.
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Rylander, Charlo ...
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Skeie, Guri
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Nøst, Therese Ha ...
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Tjønneland, Anne
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Olsen, Anja
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Pala, Valeria
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Kvaskoff, Marina
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Huybrechts, Inge
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Mancini, Frances ...
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