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Anti-transglutamina...
Anti-transglutaminase 6 antibodies in children and young adults with cerebral palsy
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- Stenberg, Reidun, 1954- (author)
- Örebro universitet,Institutionen för hälsovetenskap och medicin,Region Örebro län,Department of Pediatrics, Örebro University Hospital, Örebro, Sweden; Centre for Rehabilitation Research, Region Örebro County, Örebro, Sweden
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- Hadjivassiliou, Marios (author)
- Department of Neurology and Department of Neuroradiology,The Royal Hallamshire Hospital, Sheffield, UK
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- Aeschlimann, Pascale (author)
- Matrix Biology & Tissue Repair Research Unit, College of Biomedical and Life Sciences, School of Dentistry, Cardiff University, Cardiff, UK
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- Hoggard, Nigel (author)
- Department of Neurology and Department of Neuroradiology,The Royal Hallamshire Hospital, Sheffield, UK
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- Aeschlimann, Daniel (author)
- Matrix Biology & Tissue Repair Research Unit, College of Biomedical and Life Sciences, School of Dentistry, Cardiff University, Cardiff, UK
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(creator_code:org_t)
- Hindawi Publishing Corporation, 2014
- 2014
- English.
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In: Autoimmune Diseases. - : Hindawi Publishing Corporation. - 2090-0422 .- 2090-0430.
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https://doi.org/10.1...
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https://urn.kb.se/re...
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Abstract
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- Objectives: We have previously reported a high prevalence of gluten-related serological markers (GRSM) in children and young adults with cerebral palsy (CP). The majority had no enteropathy to suggest coeliac disease (CD). Antibodies against transglutaminase 6 (anti-TG6) represent a new marker associated with gluten-related neurological dysfunction. The aim of this study was to investigate the prevalence of anti-TG6 antibodies in this group of individuals with an early neurological injury resulting in CP.Materials and Methods: Sera from 96 patients with CP and 36 controls were analysed for IgA/IgG class anti-TG6 by ELISA.Results: Anti-TG6 antibodies were found in 12/96 (13%) of patients with CP compared to 2/36 (6%) in controls. The tetraplegic subgroup of CP had a significantly higher prevalence of anti-TG6 antibodies 6/17 (35%) compared to the other subgroups and controls. There was no correlation of anti-TG6 autoantibodies with seropositivity to food proteins including gliadin.Conclusions: An early brain insult and associated inflammation may predispose to future development of TG6 autoimmunity.
Subject headings
- MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin -- Pediatrik (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Clinical Medicine -- Pediatrics (hsv//eng)
Publication and Content Type
- ref (subject category)
- art (subject category)
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