| 1. |
- Ademuyiwa, Adesoji O., et al.
(författare)
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Determinants of morbidity and mortality following emergency abdominal surgery in children in low-income and middle-income countries
- 2016
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Ingår i: BMJ Global Health. - : BMJ Publishing Group Ltd. - 2059-7908. ; 1:4
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Tidskriftsartikel (refereegranskat)abstract
- Background: Child health is a key priority on the global health agenda, yet the provision of essential and emergency surgery in children is patchy in resource-poor regions. This study was aimed to determine the mortality risk for emergency abdominal paediatric surgery in low-income countries globally.Methods: Multicentre, international, prospective, cohort study. Self-selected surgical units performing emergency abdominal surgery submitted prespecified data for consecutive children aged <16 years during a 2-week period between July and December 2014. The United Nation's Human Development Index (HDI) was used to stratify countries. The main outcome measure was 30-day postoperative mortality, analysed by multilevel logistic regression.Results: This study included 1409 patients from 253 centres in 43 countries; 282 children were under 2 years of age. Among them, 265 (18.8%) were from low-HDI, 450 (31.9%) from middle-HDI and 694 (49.3%) from high-HDI countries. The most common operations performed were appendectomy, small bowel resection, pyloromyotomy and correction of intussusception. After adjustment for patient and hospital risk factors, child mortality at 30 days was significantly higher in low-HDI (adjusted OR 7.14 (95% CI 2.52 to 20.23), p<0.001) and middle-HDI (4.42 (1.44 to 13.56), p=0.009) countries compared with high-HDI countries, translating to 40 excess deaths per 1000 procedures performed.Conclusions: Adjusted mortality in children following emergency abdominal surgery may be as high as 7 times greater in low-HDI and middle-HDI countries compared with high-HDI countries. Effective provision of emergency essential surgery should be a key priority for global child health agendas.
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| 2. |
- Afzal, Mohammad, et al.
(författare)
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An analytical calculation of the Jacobian matrix for 3D friction contact model applied to turbine blade shroud contact
- 2016
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Ingår i: Computers & structures. - : Elsevier. - 0045-7949 .- 1879-2243. ; 177, s. 204-217
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Tidskriftsartikel (refereegranskat)abstract
- An analytical expression is formulated to compute the Jacobian matrix for 3D friction contact modeling that efficiently evaluates the matrix while computing the friction contact forces in the time domain by means of the alternate frequency time domain approach. The developed expression is successfully used for the calculation of the friction damping on a turbine blade with shroud contact interface having an arbitrary 3D relative displacement. The analytical expression drastically reduces the computation time of the Jacobian matrix with respect to the classical finite difference method, with many points at the contact interface. Therefore, it also significantly reduces the overall computation time for the solution of the equations of motion, since the formulation of the Jacobian matrix is the most time consuming step in solving the large set of nonlinear algebraic equations when a finite difference approach is employed. The equations of motion are formulated in the frequency domain using the multiharmonic balance method to accurately capture the nonlinear contact forces and displacements. Moreover, the equations of motion of the full turbine blade model are reduced to a single sector model by exploiting the concept of cyclic symmetry boundary condition for a periodic structure. Implementation of the developed scheme in solving the equations of motion is proved to be effective and significant reduction in time is achieved without loss of accuracy.
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| 3. |
- Afzal, Mohammad, et al.
(författare)
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Numerical analysis of multiple friction contacts in bladed disks
- 2018
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Ingår i: International Journal of Mechanical Sciences. - : Elsevier. - 0020-7403 .- 1879-2162. ; 137, s. 224-237
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Tidskriftsartikel (refereegranskat)abstract
- The damping potential of multiple friction contacts in a bladed disk is investigated. Friction contacts at tip shrouds and strip dampers are considered. It is shown that friction damping effectiveness can be potentially increased by using multiple friction contact interfaces. Friction damping depends on many parameters such as rotational speed, engine excitation order and mode family and therefore it is not possible to damp all the critical resonances using a single kind of friction contact interface. For example, a strip damper is more effective for the low nodal diameters, where blade/disk coupling is strong. The equations of motion of the bladed disk with multiple friction contacts are derived in the frequency domain for a cyclic structure with rotating excitations. A highly accurate method is used to generate the frequency response function (FRF) matrix. Furthermore, a finite element contact analysis is performed to compute the normal contact load and the contact area of the shroud interface at operating rotational speed. The multiharmonic balance method is employed in combination with the alternate frequency time domain method to find the steady state periodic solution. A low-pressure turbine bladed disk is considered and the effect of the engine excitation level, strip mass, thickness and the accuracy of FRF matrix on the nonlinear response curve are investigated in detail.
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| 4. |
- Afzal, Mohammad, 1987-
(författare)
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Numerical modelling and analysis of friction contact for turbine blades
- 2015
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Licentiatavhandling (övrigt vetenskapligt/konstnärligt)abstract
- High cycle fatigue failure of turbine and compressor blades due to resonance in the operating frequency range is one of the main problems in the design of gas turbine engines. To suppress excessive vibrations in the blades and prevent high cycle fatigue, dry friction dampers are used by the engine manufacturers. However, due to the nonlinear nature of friction contact, analysis of such systems becomes complicated.This work focuses on the numerical modelling of friction contact and a 3D friction contact model is developed. To reduce the computation time in the Newton-iteration steps, a method to compute the Jacobian matrix in parallel to the contact forces is proposed. The developed numerical scheme is successfully applied on turbine blades with shroud contact having an arbitrary 3D relative displacement. The equations of motion are formulated in the frequency domain using the multiharmonic balance method to accurately capture the nonlinear contact forces and displacements. Moreover, the equations of motion of the full turbine blade model are reduced to a single sector model by exploiting the concept of the cyclic symmetry boundary condition for a periodic structure.The developed 3D coupled numerical contact model is compared with a 3D contact model having uncoupled tangential motion and drawback of the uncoupled contact model is discussed. Furthermore, presence of higher harmonics in the nonlinear contact forces is analyzed and their effect on the excitation of the different harmonic indices (nodal diameters) of the bladed disk are systematically presented. Moreover, due to the quasi-analytical computation of the Jacobian matrix, the developed scheme is proved to be effective in solving the equations of motion and significant reduction in time is achieved without loss of accuracy.
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| 5. |
- Afzal, Mohammad, 1987-
(författare)
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On efficient and adaptive modelling of friction damping in bladed disks
- 2017
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Doktorsavhandling (övrigt vetenskapligt/konstnärligt)abstract
- This work focuses on efficient modelling and adaptive control of friction damping in bladed disks. To efficiently simulate the friction contact, a full-3D time-discrete contact model is reformulated and an analytical expression for the Jacobian matrix is derived that reduces the computation time drastically with respect to the classical finite difference method. The developed numerical solver is applied on bladed disks with shroud contact and the advantage of full-3D contact model compared to a quasi-3D contact model is presented. The developed numerical solver is also applied on bladed disks with strip damper and multiple friction contacts and obtained results are discussed. Furthermore, presence of higher harmonics in the nonlinear contact forces is analyzed and their effect on the excitation of the different nodal diameters of the bladed disk are systematically presented. The main parameters that influence the effectiveness of friction damping in bladed disks are engine excitation order, contact stiffnesses, friction coefficient, relative motion at the friction interface and the normal contact load. Due to variation in these parameters during operation, the obtained friction damping in practice may differ from the optimum value. Therefore, to control the normal load adaptively that will lead to an optimum damping in the system despite these variations, use of magnetostrictive actuator is proposed. The magnetostrictive material that develops an internal strain under the influence of an external magnetic field is employed to increase and decrease the normal contact load. A linearized model of the magnetostrictive actuator is used to characterize the magnetoelastic behavior of the actuator. A nonlinear static contact analysis of the bladed disk reveals that a change of normal load more than 700 N can be achieved using a reasonable size of the actuator. This will give a very good control on friction damping once applied in practice.
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| 6. |
- Afzal, Zeeshan, 1991-, et al.
(författare)
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A Wireless Intrusion Detection System for 802.11 networks
- 2016
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Ingår i: PROCEEDINGS OF THE 2016 IEEE INTERNATIONAL CONFERENCE ON WIRELESS COMMUNICATIONS, SIGNAL PROCESSING AND NETWORKING (WISPNET). - : IEEE. - 9781467393386 ; , s. 828-834
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Konferensbidrag (refereegranskat)abstract
- Wireless local area networks (WLANs) deployment is increasing rapidly. At the same time, WLANs have become an attractive target for many potential attackers. In spite of that, the de facto standard used to implement most WLANs (IEEE 802.11) has what appear to be residual vulnerabilities related to identity spoofing. In this paper, a pragmatic study of two common attacks on the standard is conducted. These attacks are then implemented on test beds to learn attack behavior. Finally, novel attack signatures and techniques to detect these attacks are devised and implemented in a proof of concept Wireless Intrusion Detection System (WIDS).
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| 7. |
- Aneja, Babita, et al.
(författare)
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Design and development of Isatin-triazole hydrazones as potential inhibitors of microtubule affinity-regulating kinase 4 for the therapeutic management of cell proliferation and metastasis
- 2019
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Ingår i: European Journal of Medicinal Chemistry. - : Elsevier BV. - 0223-5234 .- 1768-3254. ; 163, s. 840-852
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Tidskriftsartikel (refereegranskat)abstract
- Microtubule affinity-regulating kinase 4 (MARK4) is a potential drug target as the same is found to be over expressed in several types of cancers. In search of effective MARK4 inhibitors, we have synthesized and characterized Isatin-triazole hydrazones (9a-i) and evaluated their inhibitory potential. Of all the compounds, 9g showed better binding affinity and enzyme inhibition potential in sub micromolar range. Human serum albumin (HSA) binding assay suggested an easy transportation of 9g in blood stream due to its binding affinity. In vitro anticancer studies performed on MCF-7, MDA-MB-435s and HepG2 cells using 9g showed inhibition of cell proliferation and cell migration. Further, 9g induces apoptosis in these cancerous cells, with IC50 values of 6.22, 9.94 and 8.14 mu M, respectively. Putatively, 9g seems to cause oxidative stress resulting in apoptosis. Functional assay of 9g with a panel of 26 kinases showed MARK4 specific profile. In conclusion, 9g seems to possess an effective inhibitory potential towards MARK4 adding an additional repertoire to anticancer therapeutics.
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| 8. |
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| 9. |
- Flannick, Jason, et al.
(författare)
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Data Descriptor : Sequence data and association statistics from 12,940 type 2 diabetes cases and controls
- 2017
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Ingår i: Scientific Data. - : Springer Science and Business Media LLC. - 2052-4463. ; 4
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Tidskriftsartikel (refereegranskat)abstract
- To investigate the genetic basis of type 2 diabetes (T2D) to high resolution, the GoT2D and T2D-GENES consortia catalogued variation from whole-genome sequencing of 2,657 European individuals and exome sequencing of 12,940 individuals of multiple ancestries. Over 27M SNPs, indels, and structural variants were identified, including 99% of low-frequency (minor allele frequency [MAF] 0.1-5%) non-coding variants in the whole-genome sequenced individuals and 99.7% of low-frequency coding variants in the whole-exome sequenced individuals. Each variant was tested for association with T2D in the sequenced individuals, and, to increase power, most were tested in larger numbers of individuals (> 80% of low-frequency coding variants in similar to ~82 K Europeans via the exome chip, and similar to ~90% of low-frequency non-coding variants in similar to ~44 K Europeans via genotype imputation). The variants, genotypes, and association statistics from these analyses provide the largest reference to date of human genetic information relevant to T2D, for use in activities such as T2D-focused genotype imputation, functional characterization of variants or genes, and other novel analyses to detect associations between sequence variation and T2D.
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| 10. |
- Fuchsberger, Christian, et al.
(författare)
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The genetic architecture of type 2 diabetes
- 2016
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Ingår i: Nature. - : Springer Science and Business Media LLC. - 0028-0836 .- 1476-4687. ; 536:7614, s. 41-47
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Tidskriftsartikel (refereegranskat)abstract
- The genetic architecture of common traits, including the number, frequency, and effect sizes of inherited variants that contribute to individual risk, has been long debated. Genome-wide association studies have identified scores of common variants associated with type 2 diabetes, but in aggregate, these explain only a fraction of the heritability of this disease. Here, to test the hypothesis that lower-frequency variants explain much of the remainder, the GoT2D and T2D-GENES consortia performed whole-genome sequencing in 2,657 European individuals with and without diabetes, and exome sequencing in 12,940 individuals from five ancestry groups. To increase statistical power, we expanded the sample size via genotyping and imputation in a further 111,548 subjects. Variants associated with type 2 diabetes after sequencing were overwhelmingly common and most fell within regions previously identified by genome-wide association studies. Comprehensive enumeration of sequence variation is necessary to identify functional alleles that provide important clues to disease pathophysiology, but large-scale sequencing does not support the idea that lower-frequency variants have a major role in predisposition to type 2 diabetes.
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