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Träfflista för sökning "WFRF:(Aguilo E.) srt2:(2015-2019)"

Sökning: WFRF:(Aguilo E.) > (2015-2019)

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  • Aguilo, Francesca, et al. (författare)
  • THAP1 : role in mouse embryonic stem cell survival and differentiation
  • 2017
  • Ingår i: Stem Cell Reports. - : Cell Press. - 2213-6711. ; 9:1, s. 92-107
  • Tidskriftsartikel (refereegranskat)abstract
    • THAP1 (THAP [Thanatos-associated protein] domain-containing, apoptosis-associated protein 1) is a ubiquitously expressed member of a family of transcription factors with highly conserved DNA-binding and protein-interacting regions. Mutations in THAP1 cause dystonia, DYT6, a neurologic movement disorder. THAP1 downstream targets and the mechanism via which it causes dystonia are largely unknown. Here, we show that wild-type THAP1 regulates embryonic stem cell (ESC) potential, survival, and proliferation. Our findings identify THAP1 as an essential factor underlying mouse ESC survival and to some extent, differentiation, particularly neuroectodermal. Loss of THAP1 or replacement with a disease-causing mutation results in an enhanced rate of cell death, prolongs Nanog, Prdm14, and/or Rex1 expression upon differentiation, and results in failure to upregulate ectodermal genes. ChIP-Seq reveals that these activities are likely due in part to indirect regulation of gene expression.
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3.
  • Loiko, P., et al. (författare)
  • Inkjet-printing of graphene saturable absorbers for ~2 μm bulk and waveguide lasers
  • 2017
  • Ingår i: Optics InfoBase Conference Papers. - : Optical Society of America. - 9781943580279
  • Konferensbidrag (refereegranskat)abstract
    • We report on inkjet-printing of graphene saturable absorbers (SAs) suitable for passive Qswitching of ~2-μm bulk and waveguide lasers. Using graphene-SA in a microchip Tm:KLu(WO4)2 laser, 1.2 μJ/136 ns pulses are generated at 1917 nm.
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