| 1. |
- Ahlbeck, Lars, 1964-, et al.
(författare)
-
Intralymphatic allergen immunotherapy against pollen allergy. A 3-year open follow-up study of 10 patients
- 2018
-
Ingår i: Annals of Allergy, Asthma & Immunology. - : Elsevier. - 1081-1206 .- 1534-4436. ; 121:5, s. 626-627
-
Tidskriftsartikel (refereegranskat)abstract
- To date, allergen immunotherapy (AIT) is the only treatment that affects the long-term development of allergic rhinoconjunctivitis and induces clinical tolerance primarily by stimulating regulatory T (Treg) cells, attenuating T helper 2 (Th2) responses and synthesis of blocking antibodies1. Conventional AIT with subcutaneous injections, sublingual tablets or drops is effective, but consumes time and resources 2.
|
|
| 2. |
- Ahlberg, Daniel, et al.
(författare)
-
Competing first passage percolation on random graphs with finite variance degrees
- 2019
-
Ingår i: Random structures & algorithms (Print). - : Wiley. - 1042-9832 .- 1098-2418. ; 55:3, s. 545-559
-
Tidskriftsartikel (refereegranskat)abstract
- We study the growth of two competing infection types on graphs generated by the configuration model with a given degree sequence. Starting from two vertices chosen uniformly at random, the infection types spread via the edges in the graph in that an uninfected vertex becomes type 1 (2) infected at rate lambda(1) (lambda(2)) times the number of nearest neighbors of type 1 (2). Assuming (essentially) that the degree of a randomly chosen vertex has finite second moment, we show that if lambda(1) = lambda(2), then the fraction of vertices that are ultimately infected by type 1 converges to a continuous random variable V is an element of (0,1), as the number of vertices tends to infinity. Both infection types hence occupy a positive (random) fraction of the vertices. If lambda(1) not equal lambda(2), on the other hand, then the type with the larger intensity occupies all but a vanishing fraction of the vertices. Our results apply also to a uniformly chosen simple graph with the given degree sequence.
|
|
| 3. |
- Ahlberg Gagnér, Viktor, 1989, et al.
(författare)
-
Clustering of atomic displacement parameters in bovine trypsin reveals a distributed lattice of atoms with shared chemical properties
- 2019
-
Ingår i: Scientific Reports. - : Springer Science and Business Media LLC. - 2045-2322 .- 2045-2322. ; 9:1
-
Tidskriftsartikel (refereegranskat)abstract
- Low-frequency vibrations are crucial for protein structure and function, but only a few experimental techniques can shine light on them. The main challenge when addressing protein dynamics in the terahertz domain is the ubiquitous water that exhibit strong absorption. In this paper, we observe the protein atoms directly using X-ray crystallography in bovine trypsin at 100 K while irradiating the crystals with 0.5 THz radiation alternating on and off states. We observed that the anisotropy of atomic displacements increased upon terahertz irradiation. Atomic displacement similarities developed between chemically related atoms and between atoms of the catalytic machinery. This pattern likely arises from delocalized polar vibrational modes rather than delocalized elastic deformations or rigid-body displacements. The displacement correlation between these atoms were detected by a hierarchical clustering method, which can assist the analysis of other ultra-high resolution crystal structures. These experimental and analytical tools provide a detailed description of protein dynamics to complement the structural information from static diffraction experiments. © 2019, The Author(s).
|
|
| 4. |
|
|
| 5. |
|
|
| 6. |
- Bergfelt, Emma, et al.
(författare)
-
Satisfactory outcome after intensive chemotherapy with pragmatic use of minimal residual disease (MRD) monitoring in older patients with Philadelphia-negative B cell precursor acute lymphoblastic leukaemia : a Swedish registry-based study
- 2015
-
Ingår i: Medical Oncology. - : Springer Science and Business Media LLC. - 1357-0560 .- 1559-131X. ; 32:4
-
Tidskriftsartikel (refereegranskat)abstract
- The introduction of minimal residual disease (MRD) monitoring, in the Swedish national guidelines for acute lymphoblastic leukaemia, was evaluated in 35 patients aged 46-79 years (median 61), who were diagnosed from 2007 to 2011 and treated with high-intensity, block-based chemotherapy (ABCDV/VABA induction). Both a high complete remission rate (91 %) and acceptable overall survival (OS) rate (47 %) at 5 years were achieved. MRD by flow cytometry was measured in 73 % of the patients reaching complete remission after the first course, but was omitted by the clinicians for eight patients who were either over 70 years of age or already met conventional high-risk criteria. Factors negatively influencing OS were age over 65 years and WHO status >= 2. MRD < 0.1 % after induction had positive impact on continuous complete remission but not on OS. Only five patients were allocated to allogeneic haematopoietic stem cell transplantation in first remission, mainly due to conventional high risk factors. Thus, use of intensive remission induction therapy is effective in a selection of older patients. In a population for whom the possibilities of treatment escalation are limited, the optimal role of MRD monitoring remains to be determined.
|
|
| 7. |
- Blomqvist, Maria K., 1975, et al.
(författare)
-
Identification of a novel mutation in PEX10 in a patient with attenuated Zellweger spectrum disorder: A case report
- 2017
-
Ingår i: Journal of Medical Case Reports. - : Springer Science and Business Media LLC. - 1752-1947. ; 11:1
-
Tidskriftsartikel (refereegranskat)abstract
- Background: The peroxisome biogenesis disorders, which are caused by mutations in any of 13 different PEX genes, include the Zellweger spectrum disorders. Severe defects in one of these PEX genes result in the absence of functional peroxisomes which is seen in classical Zellweger syndrome. These patients present with hypotonia and seizures shortly after birth. Other typical symptoms are dysmorphic features, liver disease, retinal degeneration, sensorineural deafness, polycystic kidneys, and the patient does not reach any developmental milestones. Case presentation: We report a case of a patient with Zellweger spectrum disorder due to a novel mutation in the PEX10 gene, presenting with a mild late-onset neurological phenotype. The patient, an Assyrian girl originating from Iraq, presented with sensorineural hearing impairment at the age of 5 followed by sensorimotor polyneuropathy, cognitive delay, impaired gross and fine motor skills, and tremor and muscle weakness in her teens. Analyses of biochemical markers for peroxisomal disease suggested a mild peroxisomal defect and functional studies in fibroblasts confirmed the existence of a peroxisome biogenesis disorder. Diagnosis was confirmed by next generation sequencing analysis, which showed a novel homozygous mutation (c.530 T > G (p.Leu177Arg) (NM-153818.1)) in the PEX10 gene predicted to be pathogenic. Conclusions: This case highlights the importance of performing biochemical, functional, and genetic peroxisomal screening in patients with clinical presentations milder than those usually observed in Zellweger spectrum disorders. © 2017 The Author(s).
|
|
| 8. |
- Dunberger, Gail, et al.
(författare)
-
Tidig och individualiserad cancerrehabilitering viktig.
- 2015
-
Ingår i: Läkartidningen. - 1652-7518 .- 0023-7205. ; 112:50
-
Tidskriftsartikel (refereegranskat)abstract
- Survivors of gynecological cancer experience physical, psychological and existential consequences. Late gastrointestinal and urinary bladder symptoms, sexual dysfunction, including underlying physical and relational aspects, as well as lymphedema and fatigue, are common complaints. This may lead to reduced quality of life and social functioning and cancer rehabilitation is needed. Cancer rehabilitation, focusing on the individual cancer survivor and her specific needs, starting at diagnosis and continuing throughout cancer treatment and at follow-ups, is necessary.
|
|
| 9. |
- Fahlström, Gunilla, et al.
(författare)
-
Etiska aspekter på insatser inom det sociala området: En vägledning för att identifiera relevanta etiska frågor
- 2019
-
Rapport (övrigt vetenskapligt/konstnärligt)abstract
- Dessa vägledande frågor är framtagna med syftet att utgöra ett stöd för att identifiera och reflektera kring etiska aspekter vid systematisk utvärdering av insatser inom det sociala området, dvs. socialtjänst och funktionshinderområdet. Syftet är att frågorna ska minska risken för att missa relevanta etiska aspekter avseende specifika insatser. Underlaget är tänkt att användas som ett av flera steg i arbetet med etiska aspekter i SBU:s rapporter.
|
|
| 10. |
|
|
