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An evaluation of an...
An evaluation of an alternative dosing regimen with tadalafil, 3 times/week, for men with erectile dysfunction: SURE study in 14 European countries.
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Mirone, V (author)
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Costa, P (author)
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- Damber, Jan-Erik, 1949 (author)
- Gothenburg University,Göteborgs universitet,Institutionen för de kirurgiska disciplinerna, Avdelningen för urologi,Institute of Surgical Sciences, Department of Urology
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Holmes, S (author)
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Moncada, I (author)
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Van Ahlen, H (author)
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Wespes, Erik (author)
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Cordell, WH (author)
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Chan, M (author)
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Lembo, D (author)
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Varanese, L (author)
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(creator_code:org_t)
- Elsevier BV, 2005
- 2005
- English.
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In: Eur Urol. - : Elsevier BV. ; 47:6, s. 846-854
- Related links:
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https://gup.ub.gu.se...
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https://doi.org/10.1...
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Abstract
Subject headings
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- Objective: To examine the preference for 2 dosing regimens (on demand or 3 times/week) for tadalafil, a phosphodiesterase 5 inhibitor with a duration of effectiveness up to 36 hours in men with erectile dysfunction (ED). Design and methods: SURE is a 14 European country, multicenter, crossover, and open-label study. Men with ED (N = 4262) were randomized to tadalafil 20 mg treatment on demand (maximum one dose per day and before sexual activity) or 3 times/week for 5–6 weeks. After a 1-week washout period, patients were crossed over to the alternate regimen for 5–6 weeks. The patient's response to a treatment preference question (TPQ) was used to determine the preferred treatment regimen. Results: The mean age of the randomized patients was 55 years and 85.2% reported a history of ED for one year or greater. Overall, the responses of 3861 men to the TPQ assessment showed that 57.8% preferred the on-demand regimen and 42.2% preferred the 3 times/week dosing. Both regimens were efficacious and well tolerated. Conclusions: In this study, while 57.8% of men preferred the on-demand regimen of tadalafil 20 mg, a substantial number (42.2%) preferred the 3 times/week treatment. The two regimens provide additional treatment options by giving men with erectile dysfunction unique flexibility in dosing with tadalafil.
Subject headings
- MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin -- Urologi och njurmedicin (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Clinical Medicine -- Urology and Nephrology (hsv//eng)
Keyword
- Erectile dysfunction; SURE study; On demand; 3 times/week; Alternate; Tadalafil
Publication and Content Type
- ref (subject category)
- art (subject category)
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Eur Urol
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- By the author/editor
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Mirone, V
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Costa, P
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Damber, Jan-Erik ...
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Holmes, S
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Moncada, I
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Van Ahlen, H
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show more...
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Wespes, Erik
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Cordell, WH
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Chan, M
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Lembo, D
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Varanese, L
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show less...
- About the subject
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- MEDICAL AND HEALTH SCIENCES
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MEDICAL AND HEAL ...
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and Clinical Medicin ...
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and Urology and Neph ...
- Articles in the publication
- Eur Urol
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European Urology
- By the university
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University of Gothenburg