| 1. |
- Wilking, N., et al.
(författare)
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Long-term follow-up of the SBG 9401 study comparing tailored FEC-based therapy versus marrow-supported high-dose therapy
- 2007
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Ingår i: Annals of Oncology. - : Elsevier BV. - 0923-7534 .- 1569-8041. ; 18:4, s. 694-700
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Tidskriftsartikel (refereegranskat)abstract
- Background: The purpose was to investigate adjuvant marrow-supportive high-dose chemotherapy compared with an equitoxicity-tailored comparator arm. Patients and methods: Five hundred and twenty-five women below theage of 60 years with operated high-risk primary breast cancer were randomised to nine cycles of granulocyte colony-stimulating factor supported and individually tailored FEC (5-fluorouracil, epirubicin, cyclophosphamide), (n = 251) or standard FEC followed by marrow-supported high-dose therapy with CTCb (cyclophosphamide, thiotepa, carboplatin) therapy (n = 274), followed by locoregional radiotherapy and tamoxifen for 5 years. Results: There were 104 breast cancer relapses in the tailored FEC group versus 139 in the CTCb group (double triangular method by Whitehead, P = 0.046), with a median follow-up of all included patients of 60.8 months. The event-free survival demonstrated 121 and 150 events in the tailored FEC- and CTCb group, respectively [P = 0.074, hazard ratio (HR) 0.804, 95% confidence interval (CI) 0.633-1.022]. Ten patients in the tailored FEC regimen developed acute myeloid leukaemia (AML)/myelodysplasia (MDS). One hundred deaths occurred in the tailored FEC group and 121 in the CTCb group (P = 0.287, HR 0.866, 95% CI 0.665-1.129). Conclusion: The update of this study shows an improved outcome linked to the tailored FEC treatment in relation to breast cancer relapse, but also an increased incidence of AML/MDS. © 2007 Oxford University Press.
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| 2. |
- Ahlgren, G., et al.
(författare)
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Imbalance of fatty acids in the base of the Baltic sea food web - a mesocosm study.
- 2005
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Ingår i: Canadian Journal of Fisheries and Aquatic Sciences .. ; 62:, s. 2240-2253
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Tidskriftsartikel (refereegranskat)abstract
- A reproductive disturbance in Baltic Sea Atlantic salmon (Salmo salar), the M74 syndrome, has been reported since early 1970s and has occasionally caused up to 90% mortality for newborn fry. Previous research has revealed that the M74 syndrome may be due to reduced levels of the vitamin thiamin, the carotenoid astaxanthin, and elevated ratios of 3/ 6 fatty acids in salmon eggs. Using mesocosm experiments, we compared the quantity (µg•L–1) and quality (mg•g–1 C) of fatty acids in microalgae and copepods in the southern Baltic Sea where the M74 syndrome is common with those in a habitat in the Norwegian Sea where the syndrome has not been observed. Daily additions were made of the nutrients N and P or N, P, and Si, copepods were added after 6–7 days, and nutrient additions were stopped after 9–10 days. Flagellates dominated completely in the Baltic Sea, whereas higher phytoplankton diversity was found in the Norwegian Sea. We found elevated 3/ 6 ratios in phytoplankton and abnormally high docosahexaenoic acid/arachidonic acid ratios (22:6 3/20:4 6) in copepods in the Baltic Sea mesocosms compared with those in the Norwegian Sea. Our results suggest that imbalance in fatty acid composition may prevail in the basic food web of the Baltic Sea.On a signalé depuis le début des années 1970 une perturbation de la reproduction, le syndrome M74, chez le saumon atlantique (Salmo salar) de la Baltique qui, à l’occasion, cause une mortalité pouvant atteindre 90 % chez les alevins néonates. Les études antérieures ont montré que le syndrome M74 peut être dû à des concentrations faibles de la vitamine thiamine et du caroténoïde l’astaxanthine et à des rapports élevés des acides gras 3/ 6 dans les oeufs de saumons. Dans des expériences de mésocosmes, nous avons comparé la quantité (µg•L–1) et la qualité (mg•g–1 C) des acides gras dans les microalgues et les copépodes dans le sud de la Baltique où le syndrome M74 est répandu à celles d’un habitat de la mer de Norvège où le syndrome n’a pas été observé. Nous avons ajouté quotidiennement les nutriments N et P ou alors N, P et Si, introduit des copépodes au bout de 6–7 jours et arrêté les additions de nutriments après 9–10 jours. Dans la Baltique, les flagellés sont dominants, alors que, dans la mer de Norvège, le phytoplancton est plus diversifié. Dans les mésocosmes de la Baltique, les rapports 3/ 6 du phytoplancton sont élevés et les rapports acide docosahexanoïque/acide arachidonique (22:6 3/20:4 6) anormalement grands chez les copépodes, par comparaison aux mésocosmes de la mer de Norvège. Nos résultats laissent croire qu’il peut y avoir un déséquilibre dans la composition en acides gras dans le réseau alimentaire de base de la Baltique.
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| 3. |
- Brunner, M, et al.
(författare)
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Towards Ambient Networks Management
- 2005
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Ingår i: MOBILITY AWARE TECHNOLOGIES AND APPLICATIONS, PROCEEDINGS. - Berlin, Heidelberg : Springer Berlin Heidelberg. - 3540294104 ; , s. 215-229
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Konferensbidrag (refereegranskat)abstract
- Ambient Networks (AN) are under development and they are based on novel networking concepts and systems that will enable a wide range of user and business communication scenarios beyond today's fixed, 3(rd) generation mobile and IP standards. Central to this project is the concept of Ambient Control Space (ACS) and the Domain Manager control function, which manages the underlying data transfer capabilities and presents a set of interfaces towards the supported services and applications. Network Management Systems of Ambient Networks must work in an environment where heterogeneous networks compose and cooperate, on demand and transparently, without the need for manual (pre or re)-configuration or offline negotiations between network operators. To achieve these goals, ambient network management systems must become dynamic, distributed, self-managing and responsive to the network and its ambience. This paper describes the different management research challenges and four complementary solution approaches (i.e. Pattern-based Management, Peer-to-Peer Management, (Un)PnP Management, Traffic Engineering Management Application Approaches) that enable efficient management of ambient networks, and the relationships between them, and presents the main results achieved so far.
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| 4. |
- Coad, J. P., et al.
(författare)
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Overview of material re-deposition and fuel retention studies at JET with the Gas Box divertor
- 2006
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Ingår i: Nuclear Fusion. - : IOP Publishing. - 0029-5515 .- 1741-4326. ; 46:2, s. 350-366
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Tidskriftsartikel (refereegranskat)abstract
- in the period 1998-2001 the JET tokamak was operated with the MkII Gas Box divertor. On two occasions during that period a number of limiter and divertor tiles were retrieved from the torus and then examined ex situ with surface sensitive techniques. Erosion and deposition patterns were determined in order to assess the material erosion, material migration and fuel inventory on plasma facing components. Tracer techniques, e.g. injection of C-13 labelled methane and tiles coated with a low-Z and high-Z marker layer, were used to enhance the volume of information on the material transport. The results show significant asymmetry in the distribution of fuel and plasma impurity species between the inner (net deposition area) and the outer (net erosion) divertor channels. No significant formation of highly hydrogenated carbon films has been found in the Gas Box structure. The important processes for material migration, and the influence of operation scenarios on the morphology of the deposits are discussed. Comparison is also made with results obtained following previous divertor campaigns.
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| 7. |
- Likonen, J., et al.
(författare)
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Beryllium accumulation at the inner divertor of JET
- 2005
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Ingår i: Journal of Nuclear Materials. - : Elsevier BV. - 0022-3115 .- 1873-4820. ; 337-39:03-jan, s. 60-64
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Tidskriftsartikel (refereegranskat)abstract
- MkIIGB divertor tiles exposed in JET for the 1998-2001 and 1999-2001 campaigns have been used to assess the amount of beryllium and carbon deposited at the inner divertor wall. Total amount of Be at the inner divertor tiles was determined and integrated toroidally. Results were compared with data obtained with optical spectroscopy and good agreement was obtained. The amount of deposited C was computed from the amount of deposited Be assuming that the Be/C ratio arriving in the divertor is the same as the Be/C ratio in the main chamber. On the basis of this analysis we would expect there to be similar to 0.4 kg of C deposited. This gives an average C deposition rate lower than during the MkIIA phase.
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