| 1. |
- Thomas, HS, et al.
(författare)
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- 2019
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swepub:Mat__t
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| 2. |
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- 2019
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Tidskriftsartikel (refereegranskat)
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| 3. |
- Ahmed, Saad, et al.
(författare)
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Efficient intermittent computing with differential checkpointing
- 2019
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Ingår i: Proceedings of the ACM SIGPLAN Conference on Languages, Compilers, and Tools for Embedded Systems (LCTES). - New York, NY, USA : Association for Computing Machinery. - 9781450367240 ; , s. 70-81
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Konferensbidrag (refereegranskat)abstract
- Embedded devices running on ambient energy perform computations intermittently, depending upon energy availability. System support ensures forward progress of programs through state checkpointing in non-volatile memory. Checkpointing is, however, expensive in energy and adds to execution times. To reduce this overhead, we present DICE, a system design that efficiently achieves differential checkpointing in intermittent computing. Distinctive traits of DICE are its software-only nature and its ability to only operate in volatile main memory to determine differentials. DICE works with arbitrary programs using automatic code instrumentation, thus requiring no programmer intervention, and can be integrated with both reactive (Hibernus) or proactive (MementOS, HarvOS) checkpointing systems. By reducing the cost of checkpoints, performance markedly improves. For example, using DICE, Hibernus requires one order of magnitude shorter time to complete a fixed workload in real-world settings.
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| 4. |
- Ahmed, Saad, et al.
(författare)
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The betrayal of constant power × time : Finding the missing joules of transiently-powered computers
- 2019
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Ingår i: Proceedings of the ACM SIGPLAN Conference on Languages, Compilers, and Tools for Embedded Systems (LCTES). - New York, NY, USA : Association for Computing Machinery. - 9781450367240 ; , s. 97-109
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Konferensbidrag (refereegranskat)abstract
- Transiently-powered computers (TPCs) lay the basis for a battery-less Internet of Things, using energy harvesting and small capacitors to power their operation. This power supply is characterized by extreme variations in supply voltage, as capacitors charge when harvesting energy and discharge when computing. We experimentally find that these variations cause marked fluctuations in clock speed and power consumption, which determine energy efficiency. We demonstrate that it is possible to accurately model and concretely capitalize on these fluctuations. We derive an energy model as a function of supply voltage and develop EPIC, a compile-time energy analysis tool. We use EPIC to substitute for the constant power assumption in existing analysis techniques, giving programmers accurate information on worst-case energy consumption of programs. When using EPIC with existing TPC system support, run-time energy efficiency drastically improves, eventually leading up to a 350% speedup in the time to complete a fixed workload. Further, when using EPIC with existing debugging tools, programmers avoid unnecessary program changes that hurt energy efficiency.
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| 5. |
- Fitzmauric, C., et al.
(författare)
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Global, Regional, and National Cancer Incidence, Mortality, Years of Life Lost, Years Lived with Disability, and Disability-Adjusted Life-Years for 29 Cancer Groups, 1990 to 2017 : A Systematic Analysis for the Global Burden of Disease Study
- 2019
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Ingår i: JAMA Oncology. - : American Medical Association. - 2374-2437 .- 2374-2445. ; 5:12, s. 1749-1768
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Tidskriftsartikel (refereegranskat)abstract
- Importance: Cancer and other noncommunicable diseases (NCDs) are now widely recognized as a threat to global development. The latest United Nations high-level meeting on NCDs reaffirmed this observation and also highlighted the slow progress in meeting the 2011 Political Declaration on the Prevention and Control of Noncommunicable Diseases and the third Sustainable Development Goal. Lack of situational analyses, priority setting, and budgeting have been identified as major obstacles in achieving these goals. All of these have in common that they require information on the local cancer epidemiology. The Global Burden of Disease (GBD) study is uniquely poised to provide these crucial data.Objective: To describe cancer burden for 29 cancer groups in 195 countries from 1990 through 2017 to provide data needed for cancer control planning.Evidence Review: We used the GBD study estimation methods to describe cancer incidence, mortality, years lived with disability, years of life lost, and disability-adjusted life-years (DALYs). Results are presented at the national level as well as by Socio-demographic Index (SDI), a composite indicator of income, educational attainment, and total fertility rate. We also analyzed the influence of the epidemiological vs the demographic transition on cancer incidence.Findings: In 2017, there were 24.5 million incident cancer cases worldwide (16.8 million without nonmelanoma skin cancer [NMSC]) and 9.6 million cancer deaths. The majority of cancer DALYs came from years of life lost (97%), and only 3% came from years lived with disability. The odds of developing cancer were the lowest in the low SDI quintile (1 in 7) and the highest in the high SDI quintile (1 in 2) for both sexes. In 2017, the most common incident cancers in men were NMSC (4.3 million incident cases); tracheal, bronchus, and lung (TBL) cancer (1.5 million incident cases); and prostate cancer (1.3 million incident cases). The most common causes of cancer deaths and DALYs for men were TBL cancer (1.3 million deaths and 28.4 million DALYs), liver cancer (572000 deaths and 15.2 million DALYs), and stomach cancer (542000 deaths and 12.2 million DALYs). For women in 2017, the most common incident cancers were NMSC (3.3 million incident cases), breast cancer (1.9 million incident cases), and colorectal cancer (819000 incident cases). The leading causes of cancer deaths and DALYs for women were breast cancer (601000 deaths and 17.4 million DALYs), TBL cancer (596000 deaths and 12.6 million DALYs), and colorectal cancer (414000 deaths and 8.3 million DALYs).Conclusions and Relevance: The national epidemiological profiles of cancer burden in the GBD study show large heterogeneities, which are a reflection of different exposures to risk factors, economic settings, lifestyles, and access to care and screening. The GBD study can be used by policy makers and other stakeholders to develop and improve national and local cancer control in order to achieve the global targets and improve equity in cancer care.
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| 6. |
- Khan, Saad Ahmed, 1987-
(författare)
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Effects of top-of-rail friction modifiers on the friction, wear and cracks of railway rails
- 2019
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Doktorsavhandling (övrigt vetenskapligt/konstnärligt)abstract
- The railway is an economical and environmentally friendly mode of transport for long distances and heavy loads. The demands on the operators are increasing with increased competition in the market, and therefore they are currently demanding more track capacity. In the short term, the existing network is expected to deliver the increased capacity. In order to achieve increased capacity without introducing double track, either the axle load or the number of trains (i.e. the annual gross tonnage) needs to be increased, which will decrease the life of the rail and thus increase the maintenance cost. To increase the lifetime of the rails without compromising with regard to the axle load and speed, one must increase the strength of the rails, decrease the traction forces between the rails and wheels, or introduce a third body with anti-wear and anti-crack properties that can reduce the wear and rolling contact fatigue (RCF) without reducing the traction forces below the safety limit.The traction forces depend on several variables, for example third bodies in the wheel-rail interface, the train dynamics, the wheel and rail profiles, etc. Third bodies in the wheel-rail interface are one of the important influencing factors. The additive third bodies with anti-wear properties and friction reduction capabilities reduces both the wear and the RCF. However, a friction coefficient in the wheel tread and the top of the rail below 0.3 can cause slippage and a long braking distance. To reduce the degree of utilised friction to a value close to 0.35 from dry conditions with a value of 0.55, and thereby reduce the wear, a product known as top-of-rail friction modifier (TOR-FM) was developed in North America and presented in 2003 at the heavy haul conference. The TOR-FM manufacturers claim that their products provide a fixed range of friction coefficients (μ) and Kalker’s coefficients in the wheel-rail interface. Kalker’s coefficient considers the tendency of creepage between the rail and wheel as a function of the traction forces at lower creepage levels. Field and laboratory tests in the USA, Canada and China have determined the benefits of using friction control products, which include the reduction of RCF, wear, corrugation, bogie hunting, noise, and fuel consumption without any side effects. In contrast, researchers at Luleå University of Technology (LTU) have found that such products in certain conditions give unacceptably low friction that can cause long braking distances and slippage. Initial measurements performed using a wayside TOR-FM system on the Iron Ore Line (IOL – “Malmbanan” in Swedish) could not find any benefits of implementing such systems.Trafikverket is considering the implementation of the TOR-FM technology on the IOL. Directly implementing such technology can be inappropriate and expensive, because the reliability of a TOR-FM system has never been assessed for the conditions of the IOL. The IOL is the northernmost railway line in Sweden and is experiencing the problem of RCF, especially on its curves. This railway line is a single track and is mainly utilised by the ore freight trains operated by the Swedish mining company LKAB. The freight trains run by LKAB have an axle load of 30 tonnes, which is the heaviest in Europe. At present LKAB is planning to increase the axle load of their heavy haul trains to 32.5 tonnes, which will increase the RCF and wear issues.The present research investigated the effects of TOR-FMs using computer-based simulations, laboratory tests and field tests. The results from all the tests and simulations were used to calculate the life cycle cost of wayside and on-board systems. The simulation results have shown that by reducing the friction, the RCF can be reduced. This reduction in the RCF is greater on narrow curves than on larger curves as the traction forces decrease with an increase in the curve radius. Curves with a radius larger than m are not prone to RCF. The damage index method used in the simulation has also shown that on circular curves with a radius smaller than 300 m, the so-called “magic wear” rate can be achieved. Magic wear means that the wear rate due to normal operation is equal to the crack generation rate. The field results obtained using a handheld tribometer have shown that by using a TOR-FM, both the wear and the friction coefficients can be reduced. The content of the TOR-FM can have a significant effect on the carry distance and, generally, non-drying FMs have a longer carry distance. Excessive use of TOR-FM may cause unacceptably low friction and a high operational cost, and only result in an insignificant increase in the carry distance. In addition, it was also concluded that in the case of the wayside system during extreme winters, the equipment could have maintenance issues and thus a high operational cost. The on-board system is an economical alternative to the wayside system, as it has lower operation and maintenance costs. The results have also shown that snow and ice formation in the winter act as a lubricant. However, further investigations are needed to provide knowledge of the efficiency of such natural lubricants and their retention on the rail. The present research has taken the IOL as a case study, but the results will be applicable all over the world.
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| 7. |
- Mehta, Rohtesh S., et al.
(författare)
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GRFS and CRFS in alternative donor hematopoietic cell transplantation for pediatric patients with acute leukemia
- 2019
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Ingår i: Blood Advances. - : American Society of Hematology. - 2473-9529 .- 2473-9537. ; 3:9, s. 1441-1449
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Tidskriftsartikel (refereegranskat)abstract
- We report graft-versus-host disease (GVHD)-free relapse-free survival (GRFS) (a composite end point of survival without grade III-IV acute GVHD [aGVHD], systemic therapy-requiring chronic GVHD [cGVHD], or relapse) and cGVHD-free relapse-free survival (CRFS) among pediatric patients with acute leukemia (n = 1613) who underwent transplantation with 1 antigen-mismatched (7/8) bone marrow (BM; n = 172) or umbilical cord blood (UCB; n = 1441). Multivariate analysis was performed using Cox proportional hazards models. To account for multiple testing, P < .01 for the donor/graft variable was considered statistically significant. Clinical characteristics were similar between UCB and 7/8 BM recipients, because most had acute lymphoblastic leukemia (62%), 64% received total body irradiation-based conditioning, and 60% received anti-thymocyte globulin or alemtuzumab. Methotrexate-based GVHD prophylaxis was more common with 7/8 BM (79%) than with UCB (15%), in which mycophenolate mofetil was commonly used. The univariate estimates of GRFS and CRFS were 22% (95% confidence interval [CI], 16-29) and 27% (95% CI, 20-34), respectively, with 7/8 BM and 33% (95% CI, 31-36) and 38% (95% CI, 35-40), respectively, with UCB (P < .001). In multivariate analysis, 7/8 BM vs UCB had similar GRFS (hazard ratio [HR], 1.12; 95% CI, 0.87-1.45; P = .39), CRFS (HR, 1.06; 95% CI, 0.82-1.38; P = .66), overall survival (HR, 1.07; 95% CI, 0.80-1.44; P = .66), and relapse (HR, 1.44; 95% CI, 1.03-2.02; P = .03). However, the 7/8 BM group had a significantly higher risk for grade III-IV aGVHD (HR, 1.70; 95% CI, 1.16-2.48; P = .006) compared with the UCB group. UCB and 7/8 BM groups had similar outcomes, as measured by GRFS and CRFS. However, given the higher risk for grade III-IV aGVHD, UCB might be preferred for patients lacking matched donors.
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| 8. |
- Motallebzadeh, Amir, et al.
(författare)
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Microstructural, mechanical and electrochemical characterization of TiZrTaHfNb and Ti1.5ZrTa0.5Hf0.5Nb0.5 refractory high-entropy alloys for biomedical applications
- 2019
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Ingår i: Intermetallics. - : Elsevier BV. - 0966-9795. ; 113
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Tidskriftsartikel (refereegranskat)abstract
- The state-of-the-art metallic biomaterials are 316L, CoCrMo and Ti6Al4V but they all suffer from known issues relating to biocompatibility, wear resistance and corrosion resistance. Therefore, there is always the motivation to identify novel superior metallic biomaterials to 316L, CoCrMo and Ti6Al4V. The concept of refractory high-entropy alloys (RHEAs) provides an interesting research direction towards developing novel metallic biomaterials, initially because RHEAs consist of purely biocompatible elements, but a systematic study of the performance of RHEAs targeting biomedical applications, while comparing to that of the state-of-the-art 316L, CoCrMo and Ti6Al4V, was not existing before and constitutes the theme of the current work. Two exemplary RHEAs that are studied in detail in this work, TiZrTaHfNb and Ti1.5ZrTa0.5Hf0.5Nb0.5, show highly promising characteristics as novel superior metallic biomaterials in that they possess a desirable combination of wear resistance, wettability and pitting and general corrosion resistance, outperforming 316L, CoCrMo and Ti6Al4V almost in all these important aspects. In addition, it is also shown in this work that how appropriate alloying in RHEAs can be utilized to fine-tune their performance as better metallic biomaterials, such as the correlation between lattice strain and corrosion resistance.
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| 9. |
- Zhou, Qiongyu, et al.
(författare)
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Corrosion behavior of Hf0.5 Nb0.5 Ta0.5 Ti1.5 Zr refractory high-entropy in aqueous chloride solutions
- 2019
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Ingår i: Electrochemistry Communications. - : Elsevier BV. - 1388-2481. ; 98, s. 63-68
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Tidskriftsartikel (refereegranskat)abstract
- The Hf0.5Nb0.5Ta0.5Ti1.5Zr refractory high-entropy alloy with excellent corrosion resistance in the 3.5 wt% NaCl solution is identified in this work. This refractory high-entropy alloy exhibits much better general corrosion resistance than that of the 316L stainless steel, due to its corrosion current density being about one fifth of that in the latter. Meanwhile, the pitting potential of Hf0.5Nb0.5Ta0.5Ti1.5Zr reaches an unusually high value of +8.36 V, much higher than that of reported high-entropy alloys. The superior passivity of Hf0.5Nb0.5Ta0.5Ti1.5Zr is accredited to the formation of a single-phase solid solution containing high amount of homogenously distributed passivity-promoting elements, and also the existence of metallic Ta and OH− species in the passive film, which contribute to the high immunity to passive film breakdown.
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