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Systemic sclerosis ...
Systemic sclerosis and primary biliary cholangitis : Longitudinal data to determine the outcomes
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Lepri, Gemma (författare)
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- Airò, Paolo (författare)
- Spedali Civili Di Brescia
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- Distler, Oliver (författare)
- University Hospital of Zurich
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- Andréasson, Kristofer (författare)
- Lund University,Lunds universitet,Forskargruppen för systemisk skleros, Lund,Forskargrupper vid Lunds universitet,Lund Systemic Sclerosis Research Group,Lund University Research Groups
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- Braun-Moscovici, Yolanda (författare)
- Technion - Israel Institute of Technology
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- Hachulla, Eric (författare)
- Lille University Hospital
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- Balbir-Gurman, Alexandra (författare)
- Technion - Israel Institute of Technology
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- De Langhe, Ellen (författare)
- University Hospitals Leuven
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- Rednic, Simona (författare)
- University of Medicine and Pharmacy, Cluj-Napoca
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- Ingegnoli, Francesca (författare)
- University of Milan
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Rosato, Edoardo (författare)
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- Groseanu, Laura (författare)
- Carol Davila University of Medicine and Pharmacy
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- Ionescu, Ruxandra (författare)
- Carol Davila University of Medicine and Pharmacy
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Bellando-Randone, Silvia (författare)
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- Garzanova, Liudmila (författare)
- V.A. Nasonova Research Institute of Rheumatology
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- Beretta, Lorenzo (författare)
- Maggiore Hospital Policlinico
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- Bellocchi, Chiara (författare)
- Maggiore Hospital Policlinico
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- Moiseev, Sergey (författare)
- I.M. Sechenov First Moscow State Medical University
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- Novikov, Pavel (författare)
- I.M. Sechenov First Moscow State Medical University
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- Szabo, Iulia (författare)
- University of Medicine and Pharmacy, Cluj-Napoca
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- Krasowska, Dorota (författare)
- Medical University of Lublin
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- Codullo, Veronica (författare)
- Policlinico San Matteo Pavia Fondazione
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- Walker, Ulrich A. (författare)
- University Hospital Basel
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- Manolaraki, Chrysoula (författare)
- University Hospital Basel
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Guiducci, Serena (författare)
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- Truchetet, Marie Elise (författare)
- Centre Hospitalier Universitaire de Bordeaux
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- Iannone, Florenzo (författare)
- Bari University Hospital
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Tofani, Lorenzo (författare)
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- Bruni, Cosimo (författare)
- University Hospital of Zurich
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- Smith, Vanessa (författare)
- Ghent University Hospital
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- Cuomo, Giovanna (författare)
- Second University of Napels
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- Krusche, Martin (författare)
- University Medical Center Hamburg-Eppendorf
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- Matucci-Cerinic, Marco (författare)
- Maggiore Hospital Policlinico
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- Allanore, Yannick (författare)
- Assistance Publique des Hôpitaux de Paris
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(creator_code:org_t)
- 2023
- 2023
- Engelska.
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Ingår i: Journal of Scleroderma and Related Disorders. - 2397-1983. ; 8:3, s. 210-220
- Relaterad länk:
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http://dx.doi.org/10...
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https://lup.lub.lu.s...
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https://doi.org/10.1...
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Abstract
Ämnesord
Stäng
- Background: Several studies described the cross-sectional characteristics of systemic sclerosis patients and coexisting primary biliary cholangitis, but longitudinal prognostic data are lacking. Aims: To describe the systemic sclerosis–primary biliary cholangitis phenotype, including baseline characteristics and outcomes. Methods: We performed a multicentre the European Scleroderma Trials and Research Group study of systemic sclerosis patients with primary biliary cholangitis or with primary biliary cholangitis–specific antibodies, matched with systemic sclerosis controls free from hepatobiliary involvement matched for disease duration and cutaneous subset. Data were recorded at baseline and at the last available visit. Results: A total of 261 patients were enrolled (115 primary biliary cholangitis–systemic sclerosis, 161 systemic sclerosis). At baseline, systemic sclerosis–primary biliary cholangitis patients had a higher prevalence of anti-centromere antibodies (p = 0.0023) and a lower prevalence of complete absence of digital ulcers. The milder vascular involvement was confirmed at follow-up when crucial differences emerged in the percentage of patients experiencing digital ulcers; a significantly higher number of patients who never experienced digital ulcers were observed among primary biliary cholangitis–systemic sclerosis patients (p = 0.0015). Moreover, a greater incidence of pulmonary arterial hypertension (p < 0.001) and of conduction blocks (p = 0.0256) was observed in systemic sclerosis patients without primary biliary cholangitis. Patients with primary biliary cholangitis had higher levels of liver enzymes at baseline than systemic sclerosis patients; a significant decrease in liver enzymes was observed at follow-up. Out of 18 patients with cholangitis, one received a liver transplant at follow-up. Conclusion: Our data show that systemic sclerosis–primary biliary cholangitis exhibit a mild systemic sclerosis and primary biliary cholangitis phenotype with outcomes being in general favourable.
Ämnesord
- MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin -- Gastroenterologi (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Clinical Medicine -- Gastroenterology and Hepatology (hsv//eng)
Nyckelord
- autoimmunity
- fibrotic diseases
- outcomes
- overlap syndrome
- primary biliary cholangitis
- Systemic sclerosis
Publikations- och innehållstyp
- art (ämneskategori)
- ref (ämneskategori)
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- Av författaren/redakt...
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Lepri, Gemma
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Airò, Paolo
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Distler, Oliver
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Andréasson, Kris ...
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Braun-Moscovici, ...
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Hachulla, Eric
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visa fler...
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Balbir-Gurman, A ...
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De Langhe, Ellen
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Rednic, Simona
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Ingegnoli, Franc ...
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Rosato, Edoardo
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Groseanu, Laura
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Ionescu, Ruxandr ...
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Bellando-Randone ...
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Garzanova, Liudm ...
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Beretta, Lorenzo
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Bellocchi, Chiar ...
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Moiseev, Sergey
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Novikov, Pavel
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Szabo, Iulia
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Krasowska, Dorot ...
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Codullo, Veronic ...
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Walker, Ulrich A ...
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Manolaraki, Chry ...
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Guiducci, Serena
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Truchetet, Marie ...
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Iannone, Florenz ...
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Tofani, Lorenzo
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Bruni, Cosimo
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Smith, Vanessa
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Cuomo, Giovanna
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Krusche, Martin
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Matucci-Cerinic, ...
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Allanore, Yannic ...
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- Om ämnet
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- MEDICIN OCH HÄLSOVETENSKAP
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MEDICIN OCH HÄLS ...
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och Klinisk medicin
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och Gastroenterologi
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Journal of Scler ...
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Lunds universitet