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Functional adaptati...
Functional adaptation of BabA, the H. pylori ABO blood group antigen binding adhesin.
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- Aspholm-Hurtig, Marina (author)
- Umeå universitet,Oral mikrobiologi
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Dailide, Giedrius (author)
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- Lahmann, Martina, 1963 (author)
- Gothenburg University,Göteborgs universitet,Institutionen för kemi,Department of Chemistry
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Kalia, Awdhesh (author)
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- Ilver, Dag, 1959 (author)
- Gothenburg University,Göteborgs universitet,Institutionen för laboratoriemedicin, Avdelningen för klinisk kemi/transfusionsmedicin,Institute of Laboratory Medicine, Dept of Clinical Chemistry/Transfusion Medicine
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- Roche, Niamh (author)
- Lund University,Lunds universitet,Avdelningen för mikrobiologi, immunologi och glykobiologi - MIG,Institutionen för laboratoriemedicin,Medicinska fakulteten,Division of Microbiology, Immunology and Glycobiology - MIG,Department of Laboratory Medicine,Faculty of Medicine
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- Vikström, Susanne (author)
- Umeå universitet,Oral mikrobiologi
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- Sjöström, Rolf (author)
- Umeå universitet,Oral mikrobiologi
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- Lindén, Sara K., 1974 (author)
- Lund University,Lunds universitet,Institutionen för experimentell medicinsk vetenskap,Medicinska fakulteten,Department of Experimental Medical Science,Faculty of Medicine
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- Bäckström, Anna (author)
- Umeå universitet,Oral mikrobiologi
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- Lundberg, Carina (author)
- Umeå universitet,Oral mikrobiologi
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- Arnqvist, Anna (author)
- Umeå universitet,Oral mikrobiologi,Institutionen för molekylärbiologi (Medicinska fakulteten)
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- Mahdavi, Jafar (author)
- Umeå universitet,Oral mikrobiologi
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- Nilsson, Ulf (author)
- Lund University,Lunds universitet,Centrum för analys och syntes,Kemiska institutionen,Institutioner vid LTH,Lunds Tekniska Högskola,Centre for Analysis and Synthesis,Department of Chemistry,Departments at LTH,Faculty of Engineering, LTH
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Velapatiño, Billie (author)
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Gilman, Robert H (author)
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Gerhard, Markus (author)
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Alarcon, Teresa (author)
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López-Brea, Manuel (author)
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Nakazawa, Teruko (author)
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Fox, James G (author)
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Correa, Pelayo (author)
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Dominguez-Bello, Maria Gloria (author)
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Perez-Perez, Guillermo I (author)
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Blaser, Martin J (author)
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- Normark, Staffan (author)
- Karolinska Institutet
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- Carlstedt, Ingemar (author)
- Lund University,Lunds universitet,Institutionen för experimentell medicinsk vetenskap,Medicinska fakulteten,Department of Experimental Medical Science,Faculty of Medicine
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Oscarson, Stefan (author)
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- Teneberg, Susann, 1955 (author)
- Gothenburg University,Göteborgs universitet,Institutionen för medicinsk och fysiologisk kemi,Institute of Medical Biochemistry
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Berg, Douglas E (author)
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- Borén, Thomas (author)
- Umeå universitet,Institutionen för medicinsk kemi och biofysik,Oral mikrobiologi
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Lind\’e;n, Sara (author)
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Bor\’e;n, Thomas (author)
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(creator_code:org_t)
- American Association for the Advancement of Science (AAAS), 2004
- 2004
- English.
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In: Science (New York, N.Y.). - : American Association for the Advancement of Science (AAAS). - 1095-9203 .- 0036-8075. ; 305:5683, s. 519-22
- Related links:
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http://dx.doi.org/10...
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https://gup.ub.gu.se...
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https://doi.org/10.1...
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https://urn.kb.se/re...
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https://urn.kb.se/re...
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https://lup.lub.lu.s...
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Abstract
Subject headings
Close
- Adherence by Helicobacter pylori increases the risk of gastric disease. Here, we report that more than 95% of strains that bind fucosylated blood group antigen bind A, B, and O antigens (generalists), whereas 60% of adherent South American Amerindian strains bind blood group O antigens best (specialists). This specialization coincides with the unique predominance of blood group O in these Amerindians. Strains differed about 1500-fold in binding affinities, and diversifying selection was evident in babA sequences. We propose that cycles of selection for increased and decreased bacterial adherence contribute to babA diversity and that these cycles have led to gradual replacement of generalist binding by specialist binding in blood group O-dominant human populations.
Subject headings
- MEDICIN OCH HÄLSOVETENSKAP -- Medicinska och farmaceutiska grundvetenskaper -- Andra medicinska och farmaceutiska grundvetenskaper (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Basic Medicine -- Other Basic Medicine (hsv//eng)
- MEDICIN OCH HÄLSOVETENSKAP -- Medicinska och farmaceutiska grundvetenskaper -- Mikrobiologi inom det medicinska området (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Basic Medicine -- Microbiology in the medical area (hsv//eng)
- MEDICIN OCH HÄLSOVETENSKAP -- Medicinsk bioteknologi -- Medicinsk bioteknologi (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Medical Biotechnology -- Medical Biotechnology (hsv//eng)
- MEDICIN OCH HÄLSOVETENSKAP -- Medicinska och farmaceutiska grundvetenskaper (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Basic Medicine (hsv//eng)
Keyword
- ABO Blood-Group System
- metabolism
- Adaptation
- Biological
- Adhesins
- Bacterial
- chemistry
- genetics
- immunology
- metabolism
- Alleles
- Bacterial Adhesion
- Base Sequence
- Binding Sites
- Evolution
- Molecular
- Fucose
- metabolism
- Gastric Mucosa
- microbiology
- Helicobacter Infections
- microbiology
- Helicobacter pylori
- genetics
- immunology
- physiology
- Humans
- Indians
- South American
- Lewis Blood-Group System
- metabolism
- Molecular Sequence Data
- Mutation
- Peru
- Phenotype
- Phylogeny
- Protein Binding
- Selection (Genetics)
- Transformation
- Bacterial
- ABO Blood-Group System/*metabolism
Publication and Content Type
- ref (subject category)
- art (subject category)
Find in a library
To the university's database
- By the author/editor
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Aspholm-Hurtig, ...
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Dailide, Giedriu ...
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Lahmann, Martina ...
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Kalia, Awdhesh
-
Ilver, Dag, 1959
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Roche, Niamh
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show more...
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Vikström, Susann ...
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Sjöström, Rolf
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Lindén, Sara K., ...
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Bäckström, Anna
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Lundberg, Carina
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Arnqvist, Anna
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Mahdavi, Jafar
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Nilsson, Ulf
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Velapatiño, Bill ...
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Gilman, Robert H
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Gerhard, Markus
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Alarcon, Teresa
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López-Brea, Manu ...
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Nakazawa, Teruko
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Fox, James G
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Correa, Pelayo
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Dominguez-Bello, ...
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Perez-Perez, Gui ...
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Blaser, Martin J
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Normark, Staffan
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Carlstedt, Ingem ...
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Oscarson, Stefan
-
Teneberg, Susann ...
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Berg, Douglas E
-
Borén, Thomas
-
Lind\’e;n, Sara
-
Bor\’e;n, Thomas
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show less...
- About the subject
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- MEDICAL AND HEALTH SCIENCES
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MEDICAL AND HEAL ...
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and Basic Medicine
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and Other Basic Medi ...
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- MEDICAL AND HEALTH SCIENCES
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MEDICAL AND HEAL ...
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and Basic Medicine
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and Microbiology in ...
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- MEDICAL AND HEALTH SCIENCES
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MEDICAL AND HEAL ...
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and Medical Biotechn ...
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and Medical Biotechn ...
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- MEDICAL AND HEALTH SCIENCES
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MEDICAL AND HEAL ...
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and Basic Medicine
- Articles in the publication
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Science (New Yor ...
- By the university
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University of Gothenburg
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Umeå University
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Royal Institute of Technology
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Lund University
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Karolinska Institutet