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- Ekelund, Ulf, et al.
(författare)
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Myogenic vascular regulation in skeletal muscle in vivo is not dependent of endothelium-derived nitric oxide
- 1992
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Ingår i: Acta Physiologica Scandinavica. - 0001-6772. ; 144:2, s. 199-207
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Tidskriftsartikel (refereegranskat)abstract
- The hypothesis, based on in vitro experiments on large conduit arteries, that endothelium-derived nitric oxide is a mediator of vascular myogenic reactivity was tested in cat gastrocnemius muscle in vivo. This was done by comparing, in the absence and presence of effective endothelium-derived nitric oxide blockade by the specific inhibitors NG-monomethyl-L-arginine or NG-nitro-L-arginine methyl ester, myogenic responses in defined consecutive vascular sections to dynamic vascular transmural pressure stimuli, to arterial occlusion (reactive hyperaemia), and to arterial pressure changes (autoregulation of blood flow and capillary pressure). The results demonstrated that the myogenic vascular reactivity to quick ramp transmural pressure stimuli was not attenuated by endothelium-derived nitric oxide blockade, but rather reinforced. The amplitude of the reactive hyperaemia response was unaffected by endothelium-derived nitric oxide blockade, but its duration was shortened because of faster myogenic constriction, especially of large-bore arterial resistance vessels greater than 25 microns, in the recovery phase. Both the improved myogenic responsiveness to transmural pressure stimuli and the shortening of the reactive hyperaemia by endothelium-derived nitric oxide blockade suggested that endothelium-derived nitric oxide released in vivo acts as a 'metabolic' factor which certainly does not improve, but rather depresses myogenic vascular reactivity. Autoregulation of blood flow and capillary pressure were well preserved in the presence of endothelium-derived nitric oxide blockade. It was concluded from the results of these multifaceted tests that myogenic vascular regulation in skeletal muscle in vivo seems independent of endothelium-derived nitric oxide.(ABSTRACT TRUNCATED AT 250 WORDS)
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| 3. |
- Åström, Karl J., et al.
(författare)
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Facing the Challenge of Computer Science in the Industrial Applications of Control
- 1992
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Rapport (övrigt vetenskapligt/konstnärligt)abstract
- Control, signal processing, and more generally "systems" industries ignore the boundaries we have in the academic world between control, signal processing, and computer sciences. Industries think of "hardware" (electronics or computers) and "software", making little distinction between algorithms development and implementation of them. Acting as a chariman of the IFAC Technical Committee on Theory for the triennium 1990-1993, Albert Benveniste proposed in the fall of 1989 this project to investigate some fundamental questions raised by the above mentioned facts. Since CDC'90 this has been approved as a joint IEEE/CSS-IFAC project managed by the above listed group of people. A detailed progress report of the project has been written in March 20, 1991, followed by a brief update in October 19, 1991. This is summary of the conclusions of the report. Additional detailed information on the project is found in the bibliography.
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