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Sökning: WFRF:(Albu M) > (2018)

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1.
  • Vork, L., et al. (författare)
  • Development, content validity, and cross-cultural adaptation of a patient-reported outcome measure for real-time symptom assessment in irritable bowel syndrome
  • 2018
  • Ingår i: Neurogastroenterology and Motility. - : Wiley. - 1350-1925. ; 30:3
  • Tidskriftsartikel (refereegranskat)abstract
    • BackgroundEnd-of-day questionnaires, which are considered the gold standard for assessing abdominal pain and other gastrointestinal (GI) symptoms in irritable bowel syndrome (IBS), are influenced by recall and ecological bias. The experience sampling method (ESM) is characterized by random and repeated assessments in the natural state and environment of a subject, and herewith overcomes these limitations. This report describes the development of a patient-reported outcome measure (PROM) based on the ESM principle, taking into account content validity and cross-cultural adaptation. MethodsFocus group interviews with IBS patients and expert meetings with international experts in the fields of neurogastroenterology & motility and pain were performed in order to select the items for the PROM. Forward-and-back translation and cognitive interviews were performed to adapt the instrument for the use in different countries and to assure on patients' understanding with the final items. Key resultsFocus group interviews revealed 42 items, categorized into five domains: physical status, defecation, mood and psychological factors, context and environment, and nutrition and drug use. Experts reduced the number of items to 32 and cognitive interviewing after translation resulted in a few slight adjustments regarding linguistic issues, but not regarding content of the items. Conclusions and InferencesAn ESM-based PROM, suitable for momentary assessment of IBS symptom patterns was developed, taking into account content validity and cross-cultural adaptation. This PROM will be implemented in a specifically designed smartphone application and further validation in a multicenter setting will follow.
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2.
  • Lambert, SA, et al. (författare)
  • The Human Transcription Factors
  • 2018
  • Ingår i: Cell. - : Elsevier BV. - 1097-4172 .- 0092-8674. ; 172:4, s. 650-665
  • Tidskriftsartikel (refereegranskat)
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3.
  • Lambert, SA, et al. (författare)
  • The Human Transcription Factors
  • 2018
  • Ingår i: Cell. - : Elsevier BV. - 1097-4172 .- 0092-8674. ; 175:2, s. 598-599
  • Tidskriftsartikel (refereegranskat)
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