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- Alfonzo, Emilia
(författare)
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Cervical and vaginal cancer - aspects on risk factors, prevention and treatment
- 2021
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Doktorsavhandling (övrigt vetenskapligt/konstnärligt)abstract
- Background: Participation in screening is associated with a major risk reduction in cervical cancer, but there is a lack of knowledge on whether the cost to the individual has an effect on the participation rate. Women with abnormal findings at screenings are referred for colposcopy. The use of the Swedescore scoring system is recommended by the Swedish national guidelines for cervical cancer prevention. There is, however, a lack of effectiveness studies evaluating this assessment. Previous studies have shown that women with cervical high-grade lesions have an increased risk for vaginal cancer, but there is a knowledge gap regarding the risk for hysterectomised women with and without risk factors. Women with early-stage cervical cancer are treated with radical hysterectomy, which can be performed via open or minimally invasive surgery (MIS). Inferior oncologic results of MIS have been reported in international studies, which emphasises the need for further assessment of the technique’s oncological safety.Aims: To study factors influencing the prevention of cervical and vaginal cancer by means of the screening programme for cervical cancer and to evaluate surgical treatment modalities for early-stage cervical cancer.Material and methods: Paper I was a randomised controlled trial (RCT) performed on female (n = 3124) residents of low-resource areas of Gothenburg in 2013. The intervention group did not have a fee, and the control group had the standard fee. Attendance was defined as registered cytological smear within three months of invitation. In paper II, population-based register data from the National Patient Register and the Swedish Cancer Register were used in a cohort study design 1987–2011. The cohort was divided into four groups: hysterectomised with benign cervical history, hysterectomised with a history of cervical intraepithelial lesion grade 3 (CIN3), hysterectomised with prevalent CIN at surgery and non-hysterectomised. The main outcome was vaginal cancer. Paper III was a cross-sectional study linking data from the Swedish National Cervical Screening Registry (NKCx) with histological samples and a Swedescore assessment and/or colposcopic assessment by identifiable colposcopists. In Paper IV, five-year overall survival (OS) and disease-free survival (DFS) were assessed in a population-based cohort study that included all Swedish women with IA1-IB1 cervical cancer treated with radical hysterectomy from 2011 to 2017. The Swedish Quality Register for Gynecological Cancer (SQRGC) was used for identification. Results: Paper I: No difference in attendance was noted between the intervention and control groups (RR=0.93 95% CI 0.83-1.02). Nor were there any differences according to previous participation or non-participation or between the districts. Paper II: 898 vaginal cancers were included. Women with prevalent CIN at hysterectomy had a high incidence rate (IR 51.3/100 000 95% CI 34.4-76.5), followed by women with CIN3 history (IR 17.1/100 000 95% CI 12.5-23.4). Paper III: 11 317 colposcopic assessments by Swedescore were included. Sensitivity at Swedescore ≥2 was 97.5%, and the negative predictive value (NPV) was 90.2%. Specificity at ≥8 was 93.3%, and the positive predictive value (PPV) was 60.1%. Area under the ROC curve (AUC) = 0.71. In total, 24 362 colposcopies with identifiable colposcopists were analysed for accuracy. The variability in accuracy differed significantly (p-value <0.001), no effect of experience was noted (k= 0.0024). Paper IV: In total, 864 women, 236 open and 628 robotic radical hysterectomies were identified and included. There was no difference in five-year OS between groups (Hazard Ratio (HR) 1.00; 95% CI 0.50-2.01) or DFS (HR 1.08 95% CI 0.66-1.78). Conclusions: Abolishment of a fee in low-resource settings did not increase attendance. Surveillance should be offered to hysterectomised women with prevalent CIN since their risk of vaginal cancer is elevated. Abstaining from biopsy is not recommended at any Swedescore step; a referral smear should be taken into consideration before “see and treat” to lower the risk for overtreatment. The experience of colposcopists did not affect accuracy. Long-term oncological outcomes did not differ between open and robotic radical hysterectomies.
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| 2. |
- Dahm-Kähler, Pernilla, 1964, et al.
(författare)
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Uterus transplantation for fertility preservation in patients with gynecologic cancer
- 2021
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Ingår i: International Journal of Gynecological Cancer. - : BMJ. - 1048-891X .- 1525-1438. ; 31:3, s. 371-378
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Tidskriftsartikel (refereegranskat)abstract
- Cervical and endometrial cancer may impact women interested in future fertility in approximately 5-25% of cases. The recommended treatment for patients with early stage disease is hysterectomy and/or radiation leading to infertility. This is referred to as absolute uterine factor infertility. Such infertility was considered untreatable until 2014, when the first child was born after uterus transplantation. Thereafter, multiple births have been reported, mainly from women with Mayer-Rokitansky-Küster-Hauser syndrome, with congenital uterine absence, although also from a patient with iatrogenic uterine factor infertility caused by radical hysterectomy secondary to an early stage cervical cancer 7 years before uterus transplantation. A live birth after uterus transplantation may be considered promising for many who may not otherwise have this option. Uterus transplantation is a complex process including careful patient selection in both recipients and donors, in vitro fertilization, and complex surgery in the organ procurement procedure including harvesting the vessel pedicles with the thin-walled veins. Thereafter, the transplantation surgery with anastomosis to ensure optimal blood inflow and outflow of the transplanted organ. Knowledge regarding immunosuppression and pregnancy is essential. Lastly there is the hysterectomy component as the uterus must be removed. Multidisciplinary teams working closely are essential to achieve successful uterus transplantation and, ultimately, delivery of a healthy child. Both the living and deceased donor concept may be considered and we address both the advantages and disadvantages. This review summarizes the animal research thus far published on uterus transplantation, the suggested recipient selections including former gynecologic cancer patients, the living and deceased donor uterus transplantation concepts with reported results, and updated fertility outcomes. © IGCS and ESGO 2021. Re-use permitted under CC BY. Published by BMJ.
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