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- Ali, Tara, 1980-
(författare)
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Structural Studies of O-Polysaccharides from Diarrhoeal Escherichia coli
- 2007
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Doktorsavhandling (övrigt vetenskapligt/konstnärligt)abstract
- This thesis describes the structural analysis of O-polysaccharides from the Gram-negative bacterium Escherichia coli that is a diarrhoeal pathogen. The Escherichia coli serotypes investigated were O178, O171, O166 and O128. The methods used in these studies were nuclear magnetic resonance spectroscopy and component analysis.All analysed serotypes had pentasaccharide repeating units. E. coli strain O128 and O166 was shown to have the topology of four carbohydrate residues in the backbone while the 5-residue backbone is found in E. coli O178 and O171.The biological repeating units have been determined for the analysed polysaccharides and it was shown that all of the serotypes studied had a 3-substituted N-acetylgalactosamine residue at the reducing end. From this it was deduced that the terminal end of E. coli O171 and O128 have sialic acid and blood type antigens, respectively. This should make E. coli O171 and O128 less recognizable to the immune system as a foreign invader. This can result in that E. coli O171 and O128 may evade the immune system more easily.
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- Ali Yahiya, Tara, et al.
(författare)
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Seamless Interworking of WLAN and WMAN Wireless Networks
- 2006
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Konferensbidrag (refereegranskat)abstract
- Future network environments will be heterogeneous and mobile terminals will have the opportunity to dynamically select among many different access technologies. Therefore, it is important to provide service continuity in case of vertical handovers when terminals change the access technology. Two important wireless access technologies are WLAN (Wireless Local Access Networks) and WMAN (Wireless Metropolitan Access Networks) networks. In this paper, we address several challenges related to a seamless integration of those technologies. We highlight important aspects for designing a WLAN/WMAN interworking architecture and we address important Quality of Service (QoS) issues for such interworked systems like degree of QoS support provided by the technologies, QoS mapping and signalling for vertical handover. By formulating several interworking scenarios, where WLAN users with ongoing voice, video and data sessions hand over to WMAN, we study QoS and performance issues and analyse feasibility of seamless session continuity through simulations
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- Lindblad-Toh, Kerstin, et al.
(författare)
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Genome sequence, comparative analysis and haplotype structure of the domestic dog.
- 2005
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Ingår i: Nature. - : Springer Science and Business Media LLC. - 1476-4687 .- 0028-0836. ; 438:7069, s. 803-19
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Tidskriftsartikel (refereegranskat)abstract
- Here we report a high-quality draft genome sequence of the domestic dog (Canis familiaris), together with a dense map of single nucleotide polymorphisms (SNPs) across breeds. The dog is of particular interest because it provides important evolutionary information and because existing breeds show great phenotypic diversity for morphological, physiological and behavioural traits. We use sequence comparison with the primate and rodent lineages to shed light on the structure and evolution of genomes and genes. Notably, the majority of the most highly conserved non-coding sequences in mammalian genomes are clustered near a small subset of genes with important roles in development. Analysis of SNPs reveals long-range haplotypes across the entire dog genome, and defines the nature of genetic diversity within and across breeds. The current SNP map now makes it possible for genome-wide association studies to identify genes responsible for diseases and traits, with important consequences for human and companion animal health.
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