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- Allard, Per, et al.
(författare)
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Age-correlated loss of dopamine uptake sites labeled with [3H]GBR-12935 in human putamen.
- 1989
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Ingår i: Neurobiology of Aging. - 0197-4580 .- 1558-1497. ; 10:6, s. 661-4
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Tidskriftsartikel (refereegranskat)abstract
- The effects of age (19-100 years) upon dopamine uptake sites labeled with [3H]GBR-12935 in human postmortem putamen from 20 individuals were studied. There was a 70% decrease in binding density (Bmax) over the adult age range. No significant changes in binding affinity (Kd) were detected, the mean Kd being 1.0 +/- 0.2 nM (mean +/- S.E.M.). Nor were there any changes in binding related to the postmortem delay. Based on the findings that [3H]GBR-12935 labels the uptake site for dopamine, it is suggested that the age-related loss of [3H]GBR-12935 binding in human putamen reflects a degeneration of dopamine neurites.
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