| 1. |
- Clark, Andrew G., et al.
(författare)
-
Evolution of genes and genomes on the Drosophila phylogeny
- 2007
-
Ingår i: Nature. - : Springer Science and Business Media LLC. - 0028-0836 .- 1476-4687. ; 450:7167, s. 203-218
-
Tidskriftsartikel (refereegranskat)abstract
- Comparative analysis of multiple genomes in a phylogenetic framework dramatically improves the precision and sensitivity of evolutionary inference, producing more robust results than single-genome analyses can provide. The genomes of 12 Drosophila species, ten of which are presented here for the first time (sechellia, simulans, yakuba, erecta, ananassae, persimilis, willistoni, mojavensis, virilis and grimshawi), illustrate how rates and patterns of sequence divergence across taxa can illuminate evolutionary processes on a genomic scale. These genome sequences augment the formidable genetic tools that have made Drosophila melanogaster a pre-eminent model for animal genetics, and will further catalyse fundamental research on mechanisms of development, cell biology, genetics, disease, neurobiology, behaviour, physiology and evolution. Despite remarkable similarities among these Drosophila species, we identified many putatively non-neutral changes in protein-coding genes, non-coding RNA genes, and cis-regulatory regions. These may prove to underlie differences in the ecology and behaviour of these diverse species.
|
|
| 2. |
- Hernández Vera, Rodrigo, et al.
(författare)
-
Interstitial fluid flow intensity modulates endothelial sprouting in restricted Src-activated cell clusters during capillary morphogenesis
- 2009
-
Ingår i: Tissue Engineering. Part A. - : Mary Ann Liebert Inc. - 1937-3341 .- 1937-335X. ; 15:1, s. 175-185
-
Tidskriftsartikel (refereegranskat)abstract
- Development of tissues in vitro with dimensions larger than 150 to 200 microm requires the presence of a functional vascular network. Therefore, we have studied capillary morphogenesis under controlled biological and biophysical conditions with the aim of promoting vascular structures in tissue constructs. We and others have previously demonstrated that physiological values of interstitial fluid flow normal to an endothelial monolayer in combination with vascular endothelial growth factor play a critical role during capillary morphogenesis by promoting cell sprouting. In the present work, we studied the effect that a range of interstitial flow velocities (0-50 microm/min) has in promoting the amount, length, and branching of developing sprouts during capillary morphogenesis. The number of capillary-like structures developed from human umbilical vein endothelial cell monolayers across the interstitial flow values tested was not significantly affected. Instead, the length and branching degree of the sprouts presented a significant maximum at flow velocities of 10 to 20 microm/min. More-over, at these same flow values, the phosphorylation level of Src also showed its peak. We discovered that capillary morphogenesis is restricted to patches of Src-activated cells (phosphorylated Src (pSrc)) at the monolayer, suggesting that the transduction pathway in charge of sensing the mechanical stimulus induced by flow is promoting predetermined mechanically sensitive areas (pSrc) to undergo capillary morphogenesis.
|
|
| 3. |
- Piemonti, Carlos, et al.
(författare)
-
Optimal solutions for the Venezuelan unit commitment hydrothermal system
- 2006
-
Ingår i: 2006 IEEE PES Transmission and Distribution Conference and Exposition: Latin America, TDC'06. - Piscataway, NJ : IEEE Communications Society. - 1424402875 - 1424402883
-
Konferensbidrag (refereegranskat)abstract
- This work is about different optimal solutions for the unit commitment problem in the Venezuelan hydrothermal power system, disregarding the transmission system. The centralized cost-based maximum net social benefit solution, the oligopoly solution and the unregulated monopoly solution are formulated and analyzed. The oligopoly is studied via Nash-Cournot equilibrium, obtained iteratively considering both price-maker and price-taker firms. The price-demand curves are created using a price-demand elasticity parameter. The hydro plants can be of the run-of-river type or can have a regulation period, like in the case of Guri. In latter case the future profit is represented by a fixed volume of water to be turbined in the day ahead. Since integer variable are necessary to simulate the shut-down, start-up process a mixed integer commercial programming application is employed. © 2006 IEEE.
|
|
