SwePub
Sök i SwePub databas

  Utökad sökning

Träfflista för sökning "WFRF:(Amin R) srt2:(2015-2019)"

Sökning: WFRF:(Amin R) > (2015-2019)

  • Resultat 1-10 av 142
Sortera/gruppera träfflistan
   
NumreringReferensOmslagsbildHitta
1.
  • Thomas, HS, et al. (författare)
  • 2019
  • swepub:Mat__t
  •  
2.
  •  
3.
  •  
4.
  •  
5.
  •  
6.
  •  
7.
  •  
8.
  •  
9.
  • Davies, G., et al. (författare)
  • Study of 300,486 individuals identifies 148 independent genetic loci influencing general cognitive function
  • 2018
  • Ingår i: Nature Communications. - : Nature Publishing Group. - 2041-1723. ; 9:1
  • Tidskriftsartikel (refereegranskat)abstract
    • General cognitive function is a prominent and relatively stable human trait that is associated with many important life outcomes. We combine cognitive and genetic data from the CHARGE and COGENT consortia, and UK Biobank (total N = 300,486; age 16-102) and find 148 genome-wide significant independent loci (P < 5 × 10-8) associated with general cognitive function. Within the novel genetic loci are variants associated with neurodegenerative and neurodevelopmental disorders, physical and psychiatric illnesses, and brain structure. Gene-based analyses find 709 genes associated with general cognitive function. Expression levels across the cortex are associated with general cognitive function. Using polygenic scores, up to 4.3% of variance in general cognitive function is predicted in independent samples. We detect significant genetic overlap between general cognitive function, reaction time, and many health variables including eyesight, hypertension, and longevity. In conclusion we identify novel genetic loci and pathways contributing to the heritability of general cognitive function.
  •  
10.
  • Justice, A. E., et al. (författare)
  • Genome-wide meta-analysis of 241,258 adults accounting for smoking behaviour identifies novel loci for obesity traits
  • 2017
  • Ingår i: Nature Communications. - : Springer Science and Business Media LLC. - 2041-1723. ; 8
  • Tidskriftsartikel (refereegranskat)abstract
    • Few genome-wide association studies (GWAS) account for environmental exposures, like smoking, potentially impacting the overall trait variance when investigating the genetic contribution to obesity-related traits. Here, we use GWAS data from 51,080 current smokers and 190,178 nonsmokers (87% European descent) to identify loci influencing BMI and central adiposity, measured as waist circumference and waist-to-hip ratio both adjusted for BMI. We identify 23 novel genetic loci, and 9 loci with convincing evidence of gene-smoking interaction (GxSMK) on obesity-related traits. We show consistent direction of effect for all identified loci and significance for 18 novel and for 5 interaction loci in an independent study sample. These loci highlight novel biological functions, including response to oxidative stress, addictive behaviour, and regulatory functions emphasizing the importance of accounting for environment in genetic analyses. Our results suggest that tobacco smoking may alter the genetic susceptibility to overall adiposity and body fat distribution.
  •  
Skapa referenser, mejla, bekava och länka
  • Resultat 1-10 av 142
Typ av publikation
tidskriftsartikel (127)
konferensbidrag (13)
forskningsöversikt (1)
Typ av innehåll
refereegranskat (122)
övrigt vetenskapligt/konstnärligt (19)
Författare/redaktör
Amin, N (39)
van Duijn, CM (27)
Gudnason, V (27)
Metspalu, A (26)
Hofman, A (25)
Esko, T (25)
visa fler...
Hayward, C. (25)
Amin, Najaf (22)
Polašek, O. (22)
Amin, R (21)
Uitterlinden, AG (21)
Zhao, W. (19)
Smith, AV (19)
Psaty, BM (19)
Martin, NG (19)
Boerwinkle, E (19)
van Duijn, Cornelia ... (19)
Campbell, H (19)
Schmidt, H. (18)
Teumer, A (18)
Montgomery, GW (18)
Schmidt, R (18)
Lehtimaki, T. (18)
Gieger, C (18)
Hottenga, JJ (17)
Boomsma, DI (17)
Lind, Lars (17)
Vollenweider, P. (17)
Langenberg, C. (16)
Magnusson, PKE (16)
Kutalik, Z. (16)
Snieder, H. (16)
Hofer, E (15)
Deary, IJ (15)
Launer, LJ (15)
Ridker, Paul M. (15)
Chasman, Daniel I. (15)
Palotie, A (15)
Rivadeneira, F (15)
Rotter, Jerome I. (15)
Stefansson, K (15)
Rotter, JI (14)
Ikram, MA (14)
Franks, Paul W. (14)
Wareham, Nicholas J. (14)
Lahti, J (14)
Boehnke, Michael (14)
Wilson, JF (14)
Salomaa, V (14)
Franke, L (14)
visa färre...
Lärosäte
Karolinska Institutet (105)
Uppsala universitet (51)
Umeå universitet (31)
Lunds universitet (27)
Göteborgs universitet (23)
Stockholms universitet (12)
visa fler...
Kungliga Tekniska Högskolan (10)
Handelshögskolan i Stockholm (7)
Högskolan Dalarna (5)
Linköpings universitet (3)
Chalmers tekniska högskola (2)
Luleå tekniska universitet (1)
Jönköping University (1)
Sveriges Lantbruksuniversitet (1)
visa färre...
Språk
Engelska (142)
Forskningsämne (UKÄ/SCB)
Medicin och hälsovetenskap (74)
Naturvetenskap (26)
Teknik (6)
Samhällsvetenskap (3)

År

Kungliga biblioteket hanterar dina personuppgifter i enlighet med EU:s dataskyddsförordning (2018), GDPR. Läs mer om hur det funkar här.
Så här hanterar KB dina uppgifter vid användning av denna tjänst.

 
pil uppåt Stäng

Kopiera och spara länken för att återkomma till aktuell vy