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- Tahmasebi, F, et al.
(författare)
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In vitro assessment of the effects of anti-HER2 monoclonal antibodies on proliferation of HER2-overexpressing breast cancer cells
- 2014
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Ingår i: Immunotherapy. - : Future Medicine Ltd. - 1750-7448 .- 1750-743X. ; 6:1, s. 43-49
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Tidskriftsartikel (refereegranskat)abstract
- Background:HER2 proto-oncogene is critical in the biology of breast cancer and an important therapeutic target of monoclonal antibodies (mAbs). We have recently established a panel of anti-HER2 mAbs recognizing different epitopes within the extracellular domain of HER2. Materials & methods: In the present study the antiproliferative effect of these mAbs was investigated on HER2-overexpressing human breast cancer cell line BT474, using radioactive thymidine incorporation assay. Results: Our results demonstrated that while two of the mAbs (1T0 and 2A8) inhibited cell proliferation dose dependently, similar to trastuzumab, six mAbs (1F2, 1B5, 1H9, 4C7, 1H6 and 2A9) augmented cell proliferation. Treatment of BT474 cells with different combinations of two mAbs induced either synergistic inhibitory or stimulatory effects. Discussion: Our findings indicate that combination of some stimulatory mAbs could completely abolish the inhibitory effect of other mAbs against HER2. Employment of some combinations of mAbs with significant synergistic inhibitory function may improve the therapeutic efficacy of HER2-specific mAbs.
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- Leal-Ferreira, M. L., et al.
(författare)
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Rotten Egg nebula: the magnetic field of a binary evolved star
- 2012
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Ingår i: Astronomy and Astrophysics. - : EDP Sciences. - 0004-6361 .- 1432-0746. ; 540, s. Article Number: A42-
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Tidskriftsartikel (refereegranskat)abstract
- Context. Most of the planetary nebulae (PNe) observed are not spherical. The loss of spherical symmetry occurs somewhere between the asymptotic giant branch (AGB) phase and the PNe phase. The cause of this change of morphology is not yet well understood, but magnetic fields are one of the possible agents. The origin of the magnetic field remains to be determined, and potentially requires the presence of a massive companion to the AGB star. Therefore, further detections of the magnetic field around evolved stars, and in particular those thought to be part of a binary system, are crucial to improve our understanding of the origin and role of magnetism during the late stages of stellar evolution. One such binary is the pre-PN OH231.8+4.2, around which a magnetic field has previously been detected in the OH maser region of the outer circumstellar envelope. Aims. We aim to detect and infer the properties of the magnetic field of the pre-PN OH231.8+4.2 in the H2O maser region that probes the region close to the central star. This source is a confirmed binary with collimated outflows and an envelope containing several maser species. Methods. In this work we observed the 6(1,6)-5(2,3) H2O maser rotational transition to determine its linear and circular polarization. As a result of Zeeman splitting, the properties of the magnetic field can be derived from maser polarization analysis. The H2O maser emissions of OH231.8+4.2 are located within the inner regions of the source (at a few tens of AU). Results. We detected 30 H2O maser features around OH231.8+4.2. The masers occur in two distinct regions that are moving apart with a velocity on the sky of 2.3 mas/year. Taking into account the inclination angle of the source with the line of sight, this corresponds to an average separation velocity of 21 km s(-1). Based on the velocity gradient of the maser emission, the masers appear to be dragged along the direction of the nebula jet. Linear polarization is present in three of the features, and circular polarization is detected in the two brightest features. The circular polarization results imply a magnetic field strength of vertical bar B-parallel to vertical bar similar to 45 mG. Conclusions. We confirm the presence of a magnetic field around OH231.8+4.2, and report the first measurements of its strength within a few tens of AU of the stellar pair. Assuming a toroidal magnetic field, this imples B similar to 2.5 G on the stellar surface. The morphology of the field is not yet determined, but the high scatter found in the directions of the linear polarization vectors could indicate that the masers occur near the tangent points of a toroidal field.
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| 5. |
- Leal-Ferreira, M.L., et al.
(författare)
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Water Maser Emission Around Low/Intermediate Mass Evolved Stars
- 2012
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Ingår i: Proceedings of the International Astronomical Union. - 1743-9213 .- 1743-9221. ; 8:S287, s. 79 - 80
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Konferensbidrag (övrigt vetenskapligt/konstnärligt)abstract
- We present results of Very Long Baseline Array (VLBA) polarimetric 22 GHz H2O maser observations of a number of low/intermediate mass evolved stars. We observed 3 Miras (Ap Lyn, IK Tau and IRC+60370), 1 semi-regular variable (RT Vir) and 1 pPN (OH231.8+4.2). Circular polarization is detected in the H2O maser region of OH231.8+4.2 and we infer a magnetic field of |B||| = ~45 mG. This implies an extrapolated magnetic field of ~2.5 G on the surface of the central star. The preliminary results on RT Vir and IRC+60370 also indicate the first detection of weak H2O maser linear polarization.
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