| 1. |
- Andersson, Annika, 1981, et al.
(författare)
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Participation in leisure activities and binge drinking in adults – findings from a Swedish general population sample.
- 2012
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Ingår i: Addiction Research & Theory. - : Informa UK Limited. - 1606-6359 .- 1476-7392. ; 20:2, s. 172-182
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Tidskriftsartikel (refereegranskat)abstract
- The aim of this cross-sectional study was to estimate the associations between participation in different leisure activities and binge drinking in Swedish adults. The study was based on a questionnaire in a general population sample (n=3567) of individuals aged 19–64 years old. Men and women were defined as binge drinkers if they reported that they had consumed alcohol at least once a month, and stated that at a typical drinking occasion they consumed five or more standard glasses (12g of alcohol). Multivariate analyses found associations between binge drinking and socializing with friends among men aged 19–30 years (odds ratio, OR 2.88), in the 31–64 years old age group (OR 1.87). Corresponding results was found in younger women (OR 2.36). A higher OR was also found for younger men who regularly attended sporting events as spectators (OR 1.83), and among respondents in the older age group who regularly played computer or video games (OR 2.11 for women and 1.61 for men). A lower OR for binge drinking was found for men who regularly participated in religious services in both age-groups. Lower prevalence of binge drinking among women was only found in the younger group among those who regularly participated in sports/athletics or other training (OR 0.51). Our findings suggest that prevention strategies could benefit from an everyday life approach, but also that different interventions should be used in relation to specific leisure activities.
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| 2. |
- Wilbe, Maria, et al.
(författare)
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DLA Class II Alleles Are Associated with Risk for Canine Symmetrical Lupoid Onychodystropy (SLO)
- 2010
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Ingår i: PLoS ONE. - : Public Library of Science (PLoS). - 1932-6203. ; 5:8, s. e12332-
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Tidskriftsartikel (refereegranskat)abstract
- Symmetrical lupoid onychodystrophy (SLO) is an immune-mediated disease in dogs affecting the claws with a suggested autoimmune aethiology. Sequence-based genotyping of the polymorphic exon 2 from DLA-DRB1, -DQA1, and -DQB1 class II loci were performed in a total of 98 SLO Gordon setter cases and 98 healthy controls. A risk haplotype (DRB1*01801/DQA1*00101/DQB1*00802) was present in 53% of cases and 34% of controls and conferred an elevated risk of developing SLO with an odds ratio (OR) of 2.1. When dogs homozygous for the risk haplotype were compared to all dogs not carrying the haplotype the OR was 5.4. However, a stronger protective haplotype (DRB1*02001/DQA1*00401/DQB1*01303, OR = 0.03, 1/OR = 33) was present in 16.8% of controls, but only in a single case (0.5%). The effect of the protective haplotype was clearly stronger than the risk haplotype, since 11.2% of the controls were heterozygous for the risk and protective haplotypes, whereas this combination was absent from cases. When the dogs with the protective haplotype were excluded, an OR of 2.5 was obtained when dogs homozygous for the risk haplotype were compared to those heterozygous for the risk haplotype, suggesting a co-dominant effect of the risk haplotype. In smaller sample sizes of the bearded collie and giant schnauzer breeds we found the same or similar haplotypes, sharing the same DQA1 allele, over-represented among the cases suggesting that the risk is associated primarily with DLA-DQ. We obtained conclusive results that DLA class II is significantly associated with risk of developing SLO in Gordon setters, thus supporting that SLO is an immune-mediated disease. Further studies of SLO in dogs may provide important insight into immune privilege of the nail apparatus and also knowledge about a number of inflammatory disorders of the nail apparatus like lichen planus, psoriasis, alopecia areata and onycholysis.
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| 3. |
- Andersson, Annika, 1981, et al.
(författare)
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Associations between leisure activities and binge drinking in adults: Findings from a Swedish newly sick-listed sample.
- 2014
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Ingår i: Work : A journal of Prevention, Assesment and rehabilitation. - 1051-9815 .- 1875-9270. ; 48:2, s. 143-153
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Tidskriftsartikel (refereegranskat)abstract
- BACKGROUND: Leisure activities and drinking patterns are factors that can affect health and ability to return to work after a sick-leave. Associations between participation in leisure activities and binge drinking among sick-listed individuals have been paid little attention in the research literature. Objective: The aim of this study was to examine associations between leisure activities and binge drinking in a sample of newly sick-listed women and men. PARTICIPANTS: The study included 2,888 individuals aged 19-64 years. Methods: Cross-sectional questionnaire data from the Health Assets Project, Sweden, was used. Participation in 18 leisure activities was estimated. Binge drinking was defined as consuming alcohol at least once a month, and typically consuming five or more glasses. RESULTS: Among women aged 19-30 years who regularly went to concerts (OR 2.36) and wrote (OR 2.39) associations were found with binge drinking. Lower OR was found among women aged 31-64 who regularly went to the cinema (OR 0.43), out in the nature (OR 0.46) or participated in sports (OR 0.57). Among men, associations were found between socializing with friends and binge drinking in both age groups (OR 3.83 respectively 1.63). Among younger men who attended sporting events OR was 2.31, and among older men participating in religious communities OR was 0.28. CONCLUSIONS: This study contributes to understanding the interplay between leisure activities and health behavior. In particular, social activities in men were associated with binge drinking while the opposite was true for recreational activities in older women.
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| 4. |
- Andersson, Ann-Charlotte
(författare)
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Characterization of novel glomerular proteins : role in physiology and disease
- 2014
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Doktorsavhandling (övrigt vetenskapligt/konstnärligt)abstract
- Glomerular damage accounts for the majority of chronic kidney disease cases, the prevalence of which is dramatically escalating worldwide, mainly due to increase in diabetes and associated nephropathy. The costs for treatment of CKD represent an enormous burden to the health care system. Chronic kidney disease frequently progresses to end-stage renal disease with the only curative treatment options today are lifelong dialysis or kidney transplantation. In order to better understand and treat glomerular disease before it has reached this irreversible stage, it is imperative to understand the cell biology and physiology of the glomerulus including delineation of the molecular make-up of glomerular filtration barrier. This barrier constitutes the endothelial cells of the glomerular capillaries with its bound surface layer of a carbohydrate-rich meshwork (glycocalyx), the glomerular basement membrane, and the podocytes with the sub podocytes space and the attached slit diaphragm spanning between neighboring and interdigitating foot processes. Even though the concerted interplay of all layers of the glomerular filtration barrier is important for the ultra-filtration of the plasma, the podocytes and their injuries have recently been acknowledged as the major culprit of glomerular disease. In this thesis work, I describe two novel podocyte specific proteins, TDRD5 and RHPN1, which we show in vivo to be important for the integrity of the glomerular filtration barrier. TDRD5 has previously been considered a male germ cell line specific protein important for retro transposon silencing and spermiogenesis in mice. Here I show that it is expressed in mouse and human podocytes and is enriched in the zebrafish glomerulus. By using the in vivo morpholino knock down technique in zebrafish larvae it was demonstrated that TDRD5 expression is required for the proper formation of the zebrafish pronephros. RHPN1 is a RHOA binding protein which functions as an attenuator of the polymerization of actin stress fibers by regulating the phosphorylation of nonmuscle myosin II regulatory light chain through RHOA downstream effectors. Deletion of the Rhpn1 gene leads to neonatal albuminuria and glomerular basement membrane abnormality. The phenotype was characterized. As a part of efforts to elucidate expression signatures of glomerular diseases, the global glomeruli expression pattern of Adriamycin treated nephrotic mice was analyzed by RNA sequencing. The Adriamycin induced nephropathy mouse model mimics the human disease focal segmental glomerular sclerosis which constitutes one of the main causes of chronic kidney disease. The diabetic nephropathy associated single nucleotide polymorphism 3q locus was shown in our work to be a remote cis-acting variant differentially regulating glomerular NCK1 expression, implicating an important role for glomerular NCK1 in diabetic nephropathy pathogenesis.
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| 5. |
- Andersson, Charlotte, et al.
(författare)
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A risk score for predicting 30-day mortality in heart failure patients undergoing non-cardiac surgery
- 2014
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Ingår i: European Journal of Heart Failure. - : Wiley. - 1879-0844 .- 1388-9842. ; 16:12, s. 1310-1316
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Tidskriftsartikel (refereegranskat)abstract
- BackgroundHeart failure is an established risk factor for poor outcomes in patients undergoing non-cardiac surgery, yet risk stratification remains a clinical challenge. We developed an index for 30-day mortality risk prediction in this particular group. Methods and resultsAll individuals with heart failure undergoing non-cardiac surgery between October 23 2004 and October 31 2011 were included from Danish administrative registers (n=16827). In total, 1787 (10.6%) died within 30days. In a simple risk score based on the variables from the revised cardiac risk index, plus age, gender, acute surgery, and body mass index category the following variables predicted mortality (points): male gender (1), age 56-65years (2), age 66-75years (4), age 76-85years (5), or age >85years (7), being underweight (4), normal weight (3), or overweight (1), undergoing acute surgery (5), undergoing high-risk procedures (intra-thoracic, intra-abdominal, or suprainguinal aortic) (3), having renal disease (1), cerebrovascular disease (1), and use of insulin (1). The c-statistic was 0.79 and calibration was good. Mortality risk ranged from <2% for a score <5 to >50% for a score 20. Internal validation by bootstrapping (1000 re-samples) provided c-statistic of 0.79. A more complex risk score based on stepwise logistic regression including 24 variables at P<0.05 performed only slightly better, c-statistic=0.81, but was limited in use by its complexity. ConclusionsFor patients with heart failure, this simple index can accurately identify those at low risk for perioperative mortality.
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| 6. |
- Andersson, Charlotte, et al.
(författare)
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Noncardiac Surgery in Patients With Aortic Stenosis: A Contemporary Study on Outcomes in a Matched Sample From the Danish Health Care System
- 2014
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Ingår i: Clinical Cardiology. - : Wiley. - 1932-8737 .- 0160-9289. ; 37:11, s. 680-686
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Tidskriftsartikel (refereegranskat)abstract
- BackgroundPast research has identified aortic stenosis (AS) as a major risk factor for adverse outcomes in noncardiac surgery; however, more contemporary studies have questioned the grave prognosis. To further our understanding of this, the risks of a 30-day major adverse cardiovascular event (MACE) and all-cause mortality were investigated in a contemporary Danish cohort. HypothesisAS is not an independent risk factor for adverse outcomes in noncardiac surgery. MethodsAll patients with and without diagnosed AS who underwent noncardiac surgery in 2005 to 2011 were identified through nationwide administrative registers. AS patients (n=2823; mean age, 75.5years, 53% female) were matched with patients without AS (n=2823) on propensity score for AS and surgery type. ResultsIn elective surgery, MACE (ie, nonfatal myocardial infarction, ischemic stroke, or cardiovascular death) occurred in 66/1772 (3.7%) of patients with AS and 52/1772 (2.9%) of controls (P=0.19), whereas mortality occurred in 67/1772 (3.8%) AS patients and 51/1772 (2.9%) controls (P=0.13). In emergency surgery, 163/1051 (15.5%) AS patients and 120/1051 (11.4%) controls had a MACE (P=0.006), whereas 225/1051 (21.4%) vs 179/1051 (17.0%) AS patients and controls died, respectively (P=0.01). Event rates were higher for those with symptoms (defined as use of nitrates, congestive heart failure, or use of loop diuretics), compared with those without symptoms (P<0.0001). ConclusionsAS is associated with high perioperative rates of MACE and mortality, but perhaps prognosis is, in practice, not much worse for patients with AS than for matched controls. Symptomatic patients and patients undergoing emergency surgery are at considerable risks of a MACE and mortality.
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| 7. |
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| 8. |
- Andersson, Charlotte, et al.
(författare)
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The need for fundamental measurements for a sustainable extraction of metals
- 2011
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Ingår i: Mineral Processing and Extractive Metallurgy. - 0371-9553 .- 1743-2855. ; 120:2, s. 199-204
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Tidskriftsartikel (refereegranskat)abstract
- The increased need for efficient material processing and efficient utilisation of more complex raw materials and the need for recycling or reusing byproduct and waste streams, are all increased challenges in material processing. To cope with these challenges, there is a need for new basic physical and thermodynamic data. The present paper gives four examples, as well as preliminary data, of areas where increased knowledge of fundamental parameters will increase the possibility for a sustainable extraction of metals. The examples include measurement of solubility of pure individual slag minerals, determination of distribution of leachable elements between different mineralogical phases in slag, influence of alumina on liquidus temperature of a copper slag and thermal diffusivity measurements in magnetite based iron ore pellets, all important in different ways to increase the sustainability of the respective materials involved
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