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| 3. |
- Andersson, Christina, 1955, et al.
(författare)
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Användning av benzodiazepiner
- 2007
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Ingår i: Svenska Föreningen för Alkohol- och Drogforskning, forskarmöte 20071025-26.
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Konferensbidrag (övrigt vetenskapligt/konstnärligt)
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| 4. |
- Andersson, Christina, 1955, et al.
(författare)
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Dryckeskontextens betydelse för unga kvinnors alkoholkonsumtion. En klusteranalys av 20- och 25-åriga kvinnor åren 1995 och 2000.
- 2008
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Ingår i: Läkarstämman, Göteborg 2008.
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Konferensbidrag (övrigt vetenskapligt/konstnärligt)abstract
- Dryckeskontextens betydelse för unga kvinnors alkoholkonsumtion. En klusteranalys av 20- och 25-åriga kvinnor åren 1995 och 2000. Bakgrund Under de senaste åren har framför allt en del internationell drogforskning fokuserat på fenomen som dryckeskontext och egna motiv till att dricka samt dessas samband med alkoholkonsumtion. Dryckeskontext har i nämnda studier definierats på något olika sätt, några mer teoretiskt förankrade, gemensamt kan sägas att man försökt besvara frågor om var, med vem och varför man druckit alkohol I den aktuella studien har vi analyserat sambandet mellan dryckeskontext och alkoholkonsumtion bland 20- och 25-åriga kvinnor i Göteborg. Syftet var att undersöka om det fanns specifika dryckesmönster, med hänsyftning på kontextuella variabler, om dessa dryckesmönster skiljde sig åt mellan undersökningsåren och om vissa dryckesmönster visade starkare samband med olika grader av alkoholkonsumtion. Metod Data från en befolkningsundersökning, ”Kvinnor och alkohol i Göteborg”: I studien ingick 897 unga kvinnor intervjuade under åren 1995 och 2000. Då dryckeskontext kan ses som ett multifaktoriellt fenomen valde vi att använda klusteranalys (”Two-step clustering”) för att identifiera grupper med olika dryckesmönster. Vi använde Pearson Chi-square för att undersöka skillnader i alkoholkonsumtion mellan de olika grupperna. Alkoholkonsumtion fördelades som Alkoholmissbruk/beroende - ABM, Intensivkonsumtion (60g etanol/tillfälle) - IK, Intensivkonsumtion/12 mån. – IK12 och Hög alkoholkonsumtion (20g etanol/dag senaste månaden) - HAK. Resultat Med hjälp av klusteranalys identifierades tre grupper med olika dryckesmönster för varje undersökningsår. 1995 syntes en grupp måttlighetsdrickare, en grupp som drack ofta både i sociala sammanhang och i ensamhet samt en grupp som bejakade mest upplevda effekter av sitt drickande. 2000 fann vi åter gruppen måttlighetsdrickare, därtill en grupp där man bejakade sociala effekter av alkohol och en annan grupp som uppgav mer fysiska och kognitiva effekter. 1995 visade gruppen som drack i ofta i sociala sammanhang signifikanta samband med ABM, IK12 och HAK. År 2000 sågs signifikanta samband med alla konsumtionsvariablerna hos de båda grupper som bejakande olika upplevda effekter av alkoholanvändning. Sammanfattning Klusteranalys var en god metod för att identifiera grupper med olika dryckesmönster som underlag för analys av skillnader i alkoholkonsumtion. Analysen understryker vikten av att ta hänsyn till upplevda effekter av och egna anledningar till drickande när man vill medverka till en minskad alkoholkonsumtion i befolkningen.
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| 5. |
- Andersson, Christina, 1955, et al.
(författare)
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Prevalence of drug use in three cohorts of young Swedish women
- 2005
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Ingår i: Kettil Bruun Society, Annual Meeting Riverside CA, USA, 20050530-03.
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Konferensbidrag (refereegranskat)abstract
- The study presents prevalence of drug use among 1123 women aged 20 and 25 years in Göteborg, Sweden. The aim of the study was to measure prevalence of illegal and legal drug use in three cross-sectional cohorts interviewed in 1990, 1995 and 2000 as well as to describe the development of drug use within the same period. Prevalence was calculated for illicit and licit drug use in total and for three different patterns of drug use; narcotics only, medications only or a combination of the use of these substances. Also presented is the frequency of drug use. Further was analysed trends in changes of the use of nine specified drugs. Results: Both life-time and 12-months use of illicit drugs was significantly higher for 20-year-old women in 2000 (from 20.2% to 33.4% and from 9.5% to 22.3% respectively). The use of licit drugs was highest (but not significant) among 25-year-old women in 1990. Cannabis was the most prevalent drug used with a significant increase in life-time use for 20-year-old women from 17,4% to 28,8%. Both age-groups reported significant increases in the use of heroin, 25-year-old women in use of psychedelica and 20-year-old women in use of other drugs. Conclusions: The prevalence rates found were higher than compared to contemporary studies in Sweden. Further was found a significant trend for using both illegal and legal drugs among the youngest cohort, and a tendency for more regular use of drugs in both age-groups in 2000.
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| 6. |
- Andersson, Christina, 1955, et al.
(författare)
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The association between patterns of women’s daily occupations and alcohol consumption; a cluster analytic approach.
- 2009
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Ingår i: 35th Annual Alcohol Epidemiology Symposium of the Kettil Bruun Society, Köpenhamn, DK 2009601-05.
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Konferensbidrag (refereegranskat)abstract
- Earlier studies on women's health and women's drinking and contemporary associated risk factors have highlighted the need for more complex approaches in understanding the pathways into women's problem drinking. Research from both social science and occupational therapy theory have underlined the importance of deconstructing the often dichotomised way of investigating women's daily lives (such as in paid and unpaid work or in work and leisure) when discussing factors from the daily life environment and their impact on health issues. The aim of this study is to explore the relationship between patterns of women's daily occupation and alcohol consumption using the broader concept of occupation from occupational therapy theory. Method: A cross-sectional study with data from the latest wave (2000) of a population-based project, Women and Alcohol in Göteborg (WAG). The study group consists of in total 871 women, aged 20-55 years. For identifying different groups of occupational patterns we are using an individual oriented method; Two-step clustering. Further we aim to use analyses of variance to analyse if there are specific occupational patterns related to problematic alcohol consumption. The specific variables constituting the patterns of daily occupations in this study are employment status, leisure, distribution of household/maintenance work, time for free disposal and the satisfaction with each of these four domains. Preliminary results will be presented.
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| 7. |
- Andersson, Christina, 1955, et al.
(författare)
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Young women´s drinking contexts. A cluster analysis of 20- and 25-year old women.
- 2007
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Ingår i: 33rd Annual Alcohol Epidemiology Symposium of the Kettil Bruun Society, Budapest 20070604-08.
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Konferensbidrag (refereegranskat)abstract
- During the last years some international research on young adult drinking have focused on drinking contexts and drinking motives and the association with alcohol consumption. In this study we have analysed the association between drinking context and alcohol consumption in 20- and 25-year old women in Sweden. The aim was to find if drinking patterns, with respect to drinking context, varied between 1995 and 2000 and if specific drinking patterns related to specific consumption variables. Method: A total of 897 respondents were interviewed in 1995 and 2000. Looking at drinking context as a multi-dimensional phenomenon we chose two-step clustering as a method for identifying the drinking patterns. We used Pearson Chi-square to test for differences between the cluster groups with respect to problematic alcohol consumption. Results: Three clusters of drinking patterns in 1995 and 2000 respectively were defined. In 1995 the clusters were characterised as moderate drinking, partying and solitary drinking and drinking effects. In 2000 the three cluster groups were moderate drinking, social effects-drinking and individual effects and solitary drinking. Association with alcohol consumption showed significant differences: in 1995 the cluster party and solitary drinking was related to alcohol use disorders, binge drinking and high alcohol consumption, in 2000 the two clusters including drinking effects showed associations with all consumption variables.
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| 8. |
- Hessle, Christina, 1965, et al.
(författare)
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Gram-positive and Gram-negative bacteria elicit different patterns of pro-inflammatory cytokines in human monocytes.
- 2005
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Ingår i: Cytokine. - : Elsevier BV. - 1043-4666. ; 30:6, s. 311-8
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Tidskriftsartikel (refereegranskat)abstract
- Pro-inflammatory cytokines secreted by tissue macrophages recruit polymorphonuclear leukocytes and evoke fever, cachexia and production of acute phase proteins. This study investigates whether Gram-positive and Gram-negative bacteria equally and efficiently trigger production of the pro-inflammatory cytokines IL-1 beta, IL-6, IL-8 and TNF-alpha in human monocytes. A range of aerobic and anaerobic Gram-positive and Gram-negative bacteria were killed by UV-light and added in different concentrations to human monocytes. Cytokines were measured in 24 h supernatants by ELISA. Gram-positive and Gram-negative bacteria were equally efficient inducers of IL-1 beta, but Gram-positive bacteria generated twice as much TNF-alpha as did Gram-negative bacteria (p<0.001 for 25 and 250 bacteria/cell). In contrast, Gram-negative bacteria induced at least twice as much IL-6 and IL-8 as did Gram-positive bacteria (p<0.001 for 2.5, 25 and 250 bacteria/cell). While the cytokine responses to LPS were similar to those induced by the corresponding amount of Gram-negative bacteria, the strong IL-1 beta and TNF-alpha responses to Gram-positive bacteria could not be induced by soluble peptidoglycan or lipotheicoic acid. The particular nature of the bacteria, thus seem to modify the response to Gram-positive bacterial components. The different cytokine profiles evoked by Gram-positive and Gram-negative bacteria might optimize clearance of bacteria that differ in cell wall structure.
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| 9. |
- Shao, Linus Ruijin, 1964, et al.
(författare)
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Ciliated epithelial-specific and regional-specific expression and regulation of the estrogen receptor-beta2 in the fallopian tubes of immature rats: a possible mechanism for estrogen-mediated transport process in vivo
- 2007
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Ingår i: American journal of physiology. - : American Physiological Society. - 0193-1849 .- 1522-1555. ; 293:1
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Tidskriftsartikel (refereegranskat)abstract
- Several ERbeta isoforms have been identified in human and rodent tissues, but it is unclear whether each isoform has distinctly different cellular targeting characteristics and physiological functions. We have investigated the intracellular localization and regulatory patterns for ERbeta isoforms in rat fallopian tubes. Western blot analysis reveals that two ERbeta isoforms corresponding to ERbeta1 and ERbeta2 are expressed in rat fallopian tubes. However, ERbeta2 is the predominant form of ERbeta in this tissue. High-resolution confocal imaging and immunohistochemical analysis provide ample evidence that ERbeta expression is limited almost exclusively to the ciliated epithelial cells, in contrast to ERalpha, which is widely distributed. Furthermore, within the ciliated epithelial cells, ERbeta is colocalized with beta-tubulin IV at stem portion of the cilia. We show that ERbeta2 protein expression is tightly regulated by E(2) or DPN in a time-dependent manner without changes in ERbeta1 expression. These estrogenic effects are inhibited by an ER antagonist, ICI 182,780. In addition, significant alteration of ERbeta immunoreactivity is detected only histologically in the ampullary region. Since the cilia are considered an essential determinant of tubal transport, we further demonstrate that E(2)- or DPN-induced ERbeta2 activation is associated with alterations in tubal protein expression crucial for the regulation of calcium-dependent ciliary beating. Given the coordinated regulation and interaction of ER and progesterone receptor in the cilia, we hypothesize that tubal ERbeta2 may facilitate the estrogen-mediated transport process by processing protein-protein interaction under physiological and/or pathological conditions. We show for the first time that a previously unrecognized localization of ERbeta isoform in rat fallopian tubes can combine with estrogen to individually control the expression of ER beta-isoforms in normal target tissues.
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