| 1. |
- Abrahamsson, Per-Anders, et al.
(författare)
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Radioimmunoassay of beta-microseminoprotein, a prostatic-secreted protein present in sera of both men and women
- 1989
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Ingår i: Clinical Chemistry. - 0009-9147. ; 35:7, s. 1497-1503
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Tidskriftsartikel (refereegranskat)abstract
- We describe a simple radioimmunoassay of beta-microseminoprotein, one of the three most abundant secretory proteins of the prostate gland. The detection limit of the assay is 1 microgram/L, and its precision, expressed as the total coefficient of variation, is less than 10% for values between 10 and 150 micrograms/L. Using this assay, we found that beta-microseminoprotein immunoreactivity was present in sera from both sexes at about the same concentration. The protein detected had the same molecular size on gel chromatography as the protein isolated from seminal plasma, and dilution curves for the sera paralleled that for the pure protein. The findings suggest that beta-microseminoprotein is present in serum of healthy subjects of both sexes and that it originates in tissue other than the prostate gland. The range of the serum concentration was 0-10.6 micrograms/L (median 4.1) for 51 healthy adult women and 1.1-14.7 micrograms/L (median 6.2) for 35 healthy adult men not older than 40 years. In males with prostatic cancer the concentration in serum was highly variable and often greatly increased. The concentration of beta-microseminoprotein was correlated with that of creatinine in serum, suggesting that the protein is eliminated--at least partly--from the circulation by glomerular filtration. Little of the protein was present in the urine of women. In urine from men the concentration was high and variable, probably because of local contribution from the prostate gland to the urethral urine.
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| 2. |
- Ahlström, Håkan, et al.
(författare)
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The spatial distribution of parenterally administered monoclonal antibodies against CEA in a human colorectal tumour xenograft
- 1989
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Ingår i: Acta Oncologica. - 0284-186X .- 1651-226X. ; 28:1, s. 81-86
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Tidskriftsartikel (refereegranskat)abstract
- A recently developed experimental model consisting of athymic rats carrying human colonic tumours from the cell line LS 174 T in both hind legs was used. 125I-labelled anti-carcinoembryonic (anti-CEA) monoclonal antibodies were injected either intra-arterially after a bolus injection of mannitol, or intra-peritoneally with or without mannitol. On the fourth day the rats were killed and pieces from the tumours and various organs were measured in a well scintillation counter. Tumour pieces were then submitted to autoradiography and immunohistochemistry for examination of the antibody distribution at the cellular level. In all examined tumours injected with anti-CEA antibodies, most of the antibodies were located in the periphery close to fibrovascular septa. It appears, in addition to the specificity of the antibody for the CEA, that the tumour vascular permeability and anatomy are of utmost importance for tumour targeting in this experimental model with the particular antibody used.
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| 3. |
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| 4. |
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| 5. |
- Andersson, Staffan, et al.
(författare)
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24-hour electrocardiographic study in myotonic dystrophy
- 1988
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Ingår i: Cardiology. - : S. Karger AG. - 0008-6312 .- 1421-9751. ; 75:4, s. 241-249
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Tidskriftsartikel (refereegranskat)abstract
- Thirty-eight consecutive adult patients with myotonic dystrophy were included in a study with electrocardiography at rest and 24-hour ambulatory electrocardiography. The patients were subdivided into three groups according to the severity of the disease. The prevalence of abnormal electrocardiograms at rest was 31, 50 and 100% in patients with mild, moderate and severe disease, respectively. The main characteristics observed at ambulatory electrocardiography were a high frequency of sinus bradycardia (58%) and intermittent atrioventricular block II (8%). These bradyarrhythmias were not correlated to the severity of the disease. Sustained atrial fibrillation or flutter was found in 3 patients (8%), all with the most severe form of the disease. Ambulatory electrocardiography should be used deliberately in the evaluation of patients with myotonic dystrophy and symptoms compatible with cardiac arrhythmias.
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| 6. |
- Andersson, Staffan, et al.
(författare)
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Echocardiographic features of myotonic dystrophy
- 1989
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Ingår i: American Journal of Noninvasive Cardiology. - : S. Karger AG. - 0258-4425 .- 2504-2378. ; 3:6, s. 354-358
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Tidskriftsartikel (refereegranskat)abstract
- Thirty adult patients with myotonic dystrophy from a defined population in northern Sweden were examined by echocardiograms were found in 1 of 7 (14%) patients with mild disease, 7 of 13 (54%) patients with moderate disease, and 6 of 10 (60%) patients with severe disease
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| 7. |
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| 8. |
- Bjerle, P, et al.
(författare)
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Electrocardiographic findings in myotonic dystrophy
- 1988
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Ingår i: British Heart Journal. - : BMJ. - 0007-0769. ; 59:1, s. 47-52
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Tidskriftsartikel (refereegranskat)abstract
- Sixty five patients with myotonic dystrophy, from a defined population in northern Sweden with an extremely high prevalence of this disease, were examined by electrocardiography. The patients were subdivided into three groups according to the severity of the disease. Abnormal electrocardiograms were found in 6 (35%) patients with mild disease, 12 (50%) patients with moderate disease, and 23 (96%) patients with severe disease. First degree atrioventricular block and left anterior hemiblock were the most commonly encountered abnormalities in patients with mild and moderate disease, whereas atrial fibrillation and flutter, abnormal Q waves, and repolarisation abnormalities were more common in patients with severe disease. This study shows that the heart is often affected by myotonic dystrophy. These effects can be detected by electrocardiography in early and mild forms of the disease. The effect on the heart is progressive and clinically important atrial arrhythmias and electrocardiographic abnormalities which are useful in differential diagnosis are common in severe forms of the disease.
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| 9. |
- Girhammar, Ulf Arne, et al.
(författare)
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Effect of loading rate on nailed timber joint capacity
- 1988
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Ingår i: Journal of Structural Engineering. - : American Society of Civil Engineers (ASCE). - 0733-9445 .- 1943-541X. ; 114:11, s. 2439-2456
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Tidskriftsartikel (refereegranskat)abstract
- The present study addresses the loading or deformation rate effect on the yield loads of nailed timber joints. Four different types of joints, which differed with respect to the thickness of the members and the angle of load to grain, were tested. The bearing strength of the wood and the bending strength of the nails were also tested in order to analytically verify the dynamic ultimate capacity of the joints. All tests were run with deformation rates from static loading values up to approximately 1 m/s (40 in./s). The pilot study results show that the strength of the nailed joints can be expressed in terms of the deformation rate. A logarithmic expression for the strength of the joints was obtained from regression analysis of approximately 200 results. The values obtained analytically agreed well with the experimental ones for the various joints tested
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| 10. |
- von Schantz, Torbjörn, et al.
(författare)
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Female choice - Reply
- 1989
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Ingår i: Nature. - : Springer Science and Business Media LLC. - 0028-0836 .- 1476-4687. ; 339:6224, s. 432-433
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Tidskriftsartikel (refereegranskat)
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