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| 2. |
- Andersson, Maria L.E., et al.
(författare)
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Autoantibodies to Disease-Related Proteins in Joints as Novel Biomarkers for the Diagnosis of Rheumatoid Arthritis
- 2023
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Ingår i: Arthritis & Rheumatology. - : Wiley. - 2326-5191 .- 2326-5205. ; 75:7, s. 1110-1119
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Tidskriftsartikel (refereegranskat)abstract
- Objective. This study was undertaken to develop and characterize a multiplex immunoassay for detection of autoantibodies against peptides derived from proteins known to play a role in development of arthritis and that are also expressed in joints.Methods. We selected peptides from the human counterpart of proteins expressed in the joints, based on mouse models that showed these to be targeted by pathogenic or regulatory antibodies in vivo. Using bead-based flow immunoassays measuring IgG antibodies, we selected triple helical or cyclic peptides, containing the epitopes, to avoid collinear reactivity. We characterized the analytical performance of the immunoassay and then validated it in 3 independent rheumatoid arthritis (RA) cohorts (n = 2,110), Swedish age- and sex-matched healthy controls, and patients with osteoarthritis (OA), patients with psoriatic arthritis (PsA), and patients with systemic lupus erythematosus (SLE).Results. Screening assays showed 5 peptide antigens that discriminated RA patients from healthy controls with 99% specificity (95% confidence interval [CI] 98-100%). In our validation studies, we reproduced the discriminatory capacity of the autoantibodies in 2 other RA cohorts, showing that the autoantibodies had high discriminatory capacity for RA versus OA, PsA, and SLE. The novel biomarkers identified 22.5% (95% CI 19-26%) of early RA patients seronegative for anti-cyclic citrullinated peptide and rheumatoid factor. The usefulness of the biomarkers in identifying seronegative RA patients was confirmed in validation studies using 2 independent cohorts of RA patients and cohorts of patients with OA, PsA, and SLE.Conclusion. A multiplex immunoassay with peptides from disease-related proteins in joints was found to be useful for detection of specific autoantibodies in RA serum. Of note, this immunoassay had high discriminatory capacity for early seronegative RA.
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| 3. |
- Agelii, Monica Leu, et al.
(författare)
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Misdiagnosis of Rheumatoid Arthritis in a Long-Term Cohort of Early Arthritis Based on the ACR-1987 Classification Criteria
- 2022
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Ingår i: Open Access Rheumatology: Research and Reviews. - 1179-156X. ; 14, s. 187-194
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Tidskriftsartikel (refereegranskat)abstract
- Objective: Correct diagnosis of early rheumatoid arthritis (RA) is essential for optimal treatment choices. No pathognomonic test is available, and diagnosis is based on classification criteria, which can result in misdiagnosis. Here, we examined the differences between actual and misdiagnosed RA cases in a long-term cohort of patients included based on the ACR-1987 classification criteria. Methods: Patients in the BARFOT (Better Anti-Rheumatic PharmacOTherapy) cohort (n=2543) with at least four follow-up visits during the initial 5 years from enrolment were assessed, and a change in diagnosis was reported by the treating rheumatologist. The groups were analysed with respect to the individual classification criteria, antibodies to citrullinated proteins (ACPA), disease activity (DAS28) and radiographic changes from inclusion up to 2 years. Results: Forty-five patients (1.8%) were misdiagnosed (RA-change group). When compared to those in the RA-change group, the patients who kept their diagnosis (RA-keep) were more often RF positive (64% vs 21%, p<0.001) or ACPA positive (59% vs 8%, p<0.001). They were also more likely to fulfil more than four ACR-1987 criteria (64% vs 33%, p<0.001) and to have radiographic changes at inclusion (RA-keep 27% vs RA-change 12%, p=0.04). The groups had a similar evolution of DAS28 and its components as well as of radiological joint destruction. Conclusion: Diagnosis of RA according to the ACR-1987 criteria had a high precision in this long-term cohort. A diagnosis of RA should be re-evaluated in patients who do not fulfil more than four ACR-1987 criteria especially in patients negative for RF.
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| 4. |
- Aguilar, Mónica García, et al.
(författare)
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Governance challenges and opportunities for implementing resource recovery from organic waste streams in urban areas of Latin America: insights from Chía, Colombia
- 2022
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Ingår i: Sustainable Production and Consumption. - : Elsevier. - 2352-5509. ; 30, s. 53-63
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Tidskriftsartikel (refereegranskat)abstract
- Across the globe, there is increasing interest in implementing circular approaches to urban sanitation and waste management to mitigate environmental challenges and promote sustainable business opportunities. In Latin America where 80% of the population live in urban areas, there is limited investigation into the enabling factors and governance barriers that are critical to implementing circular economy strategies in urban areas. This paper aims at assessing the governance capacity to implement resource recovery from organic waste streams in the municipality of Chía, Colombia, through applying the Governance Capacity Framework in a participatory process with local stakeholders. The findings highlight the importance of local initiatives for resource recovery that allow experimentation, raise awareness and foster collaboration, as well as mechanisms available for public participation in decision-making processes as enabling factors. Meanwhile, the inadequate monitoring and assessment of environmental strategies and policies, inadequate sharing of information among stakeholders and the relative low awareness of potential benefits of recovering resources from organic waste streams, especially among public sector actors, emerge as key barriers. Beyond Chía, the results provide insights on crucial factors for ensuring sufficient governance capacity in other urban areas in low- and middle-income countries which are considering circular approaches to urban sanitation and waste management. The findings also provide an empirical basis to advance the understanding of the governance conditions necessary for implementing resource recovery from organic waste streams, upon which further applications of the governance capacity framework along with participatory aspects in other similar urban contexts could build.
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| 5. |
- Andersson, Monica, 1948-
(författare)
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Förord
- 2020
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Ingår i: Stockholms vattenrum. - Stockholm : Samfundet S:t Erik, Svensk byggtjänst. - 9789179170462 ; , s. 7-11
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Bokkapitel (övrigt vetenskapligt/konstnärligt)
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| 6. |
- Andersson, Monica, 1948-
(författare)
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Förord
- 2021
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Ingår i: Postmodernismen i Stockholm. - Stockholm : Samfundet S:t Erik. - 9789198548761 ; , s. 9-10
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Bokkapitel (övrigt vetenskapligt/konstnärligt)
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| 7. |
- Andersson, Monica, 1948-
(författare)
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Förord
- 2022
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Ingår i: Ytterstaden. - Stockholm : Appell Förlag. - 9789198664393 ; , s. 9-11
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Bokkapitel (övrigt vetenskapligt/konstnärligt)
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| 8. |
- Andersson, Monica, 1948-
(författare)
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Generalplaneinstitutet och översiktsplanen
- 2022
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Ingår i: Ytterstaden. - Stockholm : Apell Förlag. - 9789198664393 ; , s. 13-29
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Bokkapitel (övrigt vetenskapligt/konstnärligt)
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| 9. |
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| 10. |
- Andersson, Magnus, et al.
(författare)
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Short-term tagging mortality of Baltic cod (Gadus morhua)
- 2021
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Ingår i: Fisheries Research. - : Elsevier BV. - 0165-7836 .- 1872-6763. ; 234
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Tidskriftsartikel (refereegranskat)abstract
- Tagging-induced mortality experiments are an important component of mark-recapture studies, as they can be used to assess the appropriateness of the tagging methodology, and to improve the reliability of estimates of recapture rates used for calculations of mortality rates and population size. Here, short-term tagging mortality of Baltic cod was estimated through containment experiments in the southern Baltic Sea. Experimental cod were selected from trawl catches, and approximately half were tagged externally with T-bar tags and received an intraperitoneal injection of tetracycline-hydrochloride. The rest of the experimental cod formed the control group, and received neither tag nor injection. The tagged and control cod were mixed evenly within submersible cages, and held for 5-8 days. The experiments were conducted in different regions and during different months by different tagging teams. Overall mortality rate was 16 % (n = 324), with the mortality rate of the tagged group 19 %, and the mortality rate of the control group 13 %. A general linear mixed model was fit to assess the effect of tagging, month, experiment duration, fish length and tagging site (i.e. the combined effect of region and tagging team) on mortality. Tagging had no effect on mortality, indicating that mortality can be attributed mainly to the capture and handling procedure. There was a significantly negative relationship between fish length (range: 20-55 cm) and mortality. Mortality did not differ between the months tested, but there was a significant effect of tagging site on mortality. Tagging-related mortality should be accounted for in analyses of data from mark-recapture studies of Baltic cod, and some variability in mortality between tagging sites can be expected.
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