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- Clarke, Robert, et al.
(författare)
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Lowering blood homocysteine with folic acid based supplements : Meta-analysis of randomised trials
- 1998
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Ingår i: British Medical Journal. - : BMJ. - 0959-8146. ; 316:7135, s. 894-898
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Forskningsöversikt (refereegranskat)abstract
- Objective: To determine the size of reduction in homocysteine concentrations produced by dietary supplementation with folic acid and with vitamins B-12 or B-6. Design: Meta-analysis of randomised controlled trials that assessed the effects of folic acid based supplements on blood homocysteine concentration. Multivariate regression analysis was used to determine the effects on homocysteine concentrations of different doses of folic acid and of the addition of vitamin B-12 or B-6. Subjects: Individual data on 1114 people included in 12 trials. Findings: The proportional and absolute reductions in blood homocysteine produced by folic acid supplements were greater at higher pretreatment blood homocysteine concentrations (P < 0.001) and at lower pretreatment blood folate concentrations (P < 0.001). After standardisation to pretreatment blood concentrations of homocysteine of 12 μmol/l and of folate of 12 nmol/l (approximate average concentrations for Western populations), dietary folic acid reduced blood homocysteine concentrations by 25% (95% confidence interval 23% to 28%; P < 0.001), with similar effects in the range of 0.5-5 mg folic acid daily. Vitamin B-12 (mean 0.5 mg daily) produced an additional 7% (3% to 10%) reduction in blood homocysteine. Vitamin B-6 (mean 16.5 mg daily) did not have a significant additional effect. Conclusions: Typically in Western populations, daily supplementation with both 0.5-5 mg folic acid and about 0.5 mg vitamin B-12 would be expected to reduce blood homocysteine concentrations by about a quarter to a third (for example, from about 12 μmol/l to 8-9 μmol/l). Large scale randomised trials of such regimens in high risk populations are now needed to determine whether lowering blood homocysteine concentrations reduces the risk of vascular disease.
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- Abreu, P, et al.
(författare)
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A precise measurement of the partial decay width ratio R-b(0) = Gamma(b(b)over-bar)/Gamma(had)
- 1999
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Ingår i: EUROPEAN PHYSICAL JOURNAL C. - : SPRINGER VERLAG. - 1434-6044. ; 10:3, s. 415-442
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Tidskriftsartikel (övrigt vetenskapligt/konstnärligt)abstract
- The partial decay width of the Z to b (b) over bar quark pairs has been measured by the DELPHI detector at LEP using data taken in the years 1992 to 1995. Decays of b-hadrons were tagged by several methods using tracks with large impact parameters and/or
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- Abreu, P, et al.
(författare)
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A search for eta '(c) production in photon-photon fusion at LEP
- 1998
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Ingår i: PHYSICS LETTERS B. - : ELSEVIER SCIENCE BV. - 0370-2693. ; 441:1-4, s. 479-490
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Tidskriftsartikel (övrigt vetenskapligt/konstnärligt)abstract
- A search for the production of the eta(c)' meson, the first radial excitation of the ground state of charmonium eta(c)(2980), in the photon-photon fusion reaction at LEP has been performed using the data collected by the DELPHI detector during 1992-1996.
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- Abreu, P, et al.
(författare)
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A search for invisible Higgs bosons produced in e(+)e(-) interactions at LEP 2 energies
- 1999
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Ingår i: PHYSICS LETTERS B. - : ELSEVIER SCIENCE BV. - 0370-2693. ; 459:1-3, s. 367-381
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Tidskriftsartikel (övrigt vetenskapligt/konstnärligt)abstract
- Searches for HZ production with the Higgs boson decaying into an invisible final state have been performed with the data collected by the DELPHI experiment up to the centre-of-mass energy of 183 GeV. The hadronic and muon pair final states of the Z boson
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- Abreu, P, et al.
(författare)
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Energy dependence of event shapes and of alpha(s) at LEP 2
- 1999
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Ingår i: PHYSICS LETTERS B. - : ELSEVIER SCIENCE BV. - 0370-2693. ; 456:2-4, s. 322-340
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Tidskriftsartikel (övrigt vetenskapligt/konstnärligt)abstract
- Infrared and collinear safe event shape distributions and their mean values are determined using the data taken at five different centre of mass energies above M-Z with the DELPHI detector at LEP. From the event shapes, the strong coupling alpha(s) is ext
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- Abreu, P, et al.
(författare)
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Energy dependence of inclusive spectra in e(+)e(-) annihilation
- 1999
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Ingår i: PHYSICS LETTERS B. - : ELSEVIER SCIENCE BV. - 0370-2693. ; 459:1-3, s. 397-411
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Tidskriftsartikel (övrigt vetenskapligt/konstnärligt)abstract
- Inclusive charged hadron distributions as obtained from the DELPHI measurements at 130, 136, 161, 172 and 183 GeV are presented as a function of the variables rapidity, xi(p), p and transversal momenta. Data are compared with event generators and with MLL
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