| 1. |
- Ahmadpour, Doryaneh, 1973, et al.
(författare)
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The mitogen-activated protein kinase Slt2 modulates arsenite transport through the aquaglyceroporin Fps1
- 2016
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Ingår i: FEBS Letters. - : Wiley. - 0014-5793 .- 1873-3468. ; 590:20, s. 3649-3659
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Tidskriftsartikel (refereegranskat)abstract
- © 2016 Federation of European Biochemical Societies Arsenite is widely present in nature; therefore, cells have evolved mechanisms to prevent arsenite influx and promote efflux. In yeast (Saccharomyces cerevisiae), the aquaglyceroporin Fps1 mediates arsenite influx and efflux. The mitogen-activated protein kinase (MAPK) Hog1 has previously been shown to restrict arsenite influx through Fps1. In this study, we show that another MAPK, Slt2, is transiently phosphorylated in response to arsenite influx. Our findings indicate that the protein kinase activity of Slt2 is required for its role in arsenite tolerance. While Hog1 prevents arsenite influx via phosphorylation of T231 at the N-terminal domain of Fps1, Slt2 promotes arsenite efflux through phosphorylation of S537 at the C terminus. Our data suggest that Slt2 physically interacts with Fps1 and that this interaction depends on phosphorylation of S537. We hypothesize that Hog1 and Slt2 may affect each other's binding to Fps1, thereby controlling the opening and closing of the channel.
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| 2. |
- Bhatt, Deepak L., et al.
(författare)
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Rationale, design and baseline characteristics of the effect of ticagrelor on health outcomes in diabetes mellitus patients Intervention study
- 2019
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Ingår i: Clinical Cardiology. - : Wiley. - 0160-9289 .- 1932-8737. ; 42:5, s. 498-505
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Tidskriftsartikel (refereegranskat)abstract
- In the setting of prior myocardial infarction, the oral antiplatelet ticagrelor added to aspirin reduced the risk of recurrent ischemic events, especially, in those with diabetes mellitus. Patients with stable coronary disease and diabetes are also at elevated risk and might benefit from dual antiplatelet therapy. The Effect of Ticagrelor on Health Outcomes in diabEtes Mellitus patients Intervention Study (THEMIS, NCT01991795) is a Phase 3b randomized, double-blinded, placebo-controlled trial of ticagrelor vs placebo, on top of low dose aspirin. Patients >= 50 years with type 2 diabetes receiving anti-diabetic medications for at least 6 months with stable coronary artery disease as determined by a history of previous percutaneous coronary intervention, bypass grafting, or angiographic stenosis of >= 50% of at least one coronary artery were enrolled. Patients with known prior myocardial infarction (MI) or stroke were excluded. The primary efficacy endpoint is a composite of cardiovascular death, myocardial infarction, or stroke. The primary safety endpoint is Thrombolysis in Myocardial Infarction major bleeding. A total of 19 220 patients worldwide have been randomized and at least 1385 adjudicated primary efficacy endpoint events are expected to be available for analysis, with an expected average follow-up of 40 months (maximum 58 months). Most of the exposure is on a 60 mg twice daily dose, as the dose was lowered from 90 mg twice daily partway into the study. The results may revise the boundaries of efficacy for dual antiplatelet therapy and whether it has a role outside acute coronary syndromes, prior myocardial infarction, or percutaneous coronary intervention.
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| 3. |
- Fälth, Linda, 1973-, et al.
(författare)
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An intervention study to prevent ‘summer reading loss’ in a socioeconomically disadvantaged area with second language learners
- 2019
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Ingår i: Nordic Journal of Literacy Research. - : NOASP. - 2464-1596. ; 5:3, s. 10-23
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Tidskriftsartikel (refereegranskat)abstract
- Summer reading loss is a documented reality for many students. Research has established differences in the contribution of summer reading activity between children from families with different economic status. In this study, 120 students in Grade 2 and 115 students in Grade 3 from a socioeconomically vulnerable area participated in a summer reading intervention. In addition, a control group from the same schools comprised of 106 students from Grade 2 and 94 students from Grade 3. Almost 90% of the participating students did not have Swedish as their native language. The participants were tested on reading skills, including word decoding, nonsense-word reading, word comprehension and reading comprehension, before and after the summer vacation. The intervention was planned together with teachers from three participant schools and leisure centers. Before the summer holiday the schools arranged reading weeks and library visits. The students were encouraged to read at home during the vacation and record the number of books read on a digital platform. The results showed that the largest effect sizes between groups (intervention and control) were observed for word decoding in Grade 2 and word comprehension in Grade 3 where the intervention group improved more than the control group. If summer learning loss can be avoided or limited, the treatment can be considered worth implementing
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| 4. |
- Fälth, Linda, 1973-, et al.
(författare)
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Assessment Support as Part of Teacher Duties in the Subject of Swedish at the Elementary Level
- 2019
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Ingår i: International Journal of Learning, Teaching and Educational Research. - Flacq : Society for Research and Knowledge Management. - 1694-2493 .- 1694-2116. ; 18:4, s. 85-109
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Tidskriftsartikel (refereegranskat)abstract
- The aim of this study was to examine and describe the use of a formative assessment support regarding reading instruction in grades 1-3, viewed from a teacher perspective. Sixty-five teachers from all parts of Sweden responded to a questionnaire, who had used the support for at least one year. Of the participant teachers, nine were interviewed for the purpose of performing an in-depth analysis of the questions. The teachers stated that the primary use of the assessment results was to identify students in need of extra support, as a basis for performance appraisals, as well as for further lesson planning. Formative assessment was, on the one hand, described as a concrete practical method and, on the other hand, as an attitude. The results also indicate a feeling of frustration that, notwithstanding the current deeper insight into what every student needs, the teaching still proceeds on some middle-ground path or level.
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| 5. |
- Gustafson, Stefan, 1968-, et al.
(författare)
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Effects of a formative assessment system on early reading development
- 2019
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Ingår i: Education. - Mobile, AL, United States : Project Innovation. - 0013-1172. ; 140:1, s. 17-27
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Tidskriftsartikel (refereegranskat)abstract
- We present quantitative results from the pilot-year of a large scale Swedish educational project in reading development called LegiLexi, inspired by research within the Response to intervention and Formative assessment traditions. The vision of the project is that every pupil should reach adequate reading skills at the end of grade 3 in primary school. LegiLexi contains a formative assessment tool and a teacher course, which are linked together. We describe LegiLexi and analyze quantitative effects of the pilot year regarding reading development for pupils in grade 1. The design included three conditions; full access to LegiLexi, access only to the formative assessment tool, and control. Results showed that the group with full access to LegiLexi improved their word decoding and reading comprehension the most. For language comprehension, the Formative assessment only group showed the highest improvements. Thus, the features of LegiLexi seem to help enhance critical reading skills. Some changes will be made in the project to strengthen methodological aspects and further facilitate pupils’ reading development.
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| 6. |
- Nordström, Thomas, Filosofie doktor i psykologi, 1977-, et al.
(författare)
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Teacher inquiry of using assessments and recommendations in teaching early reading
- 2019
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Ingår i: Studies in Educational Evaluation. - : Elsevier. - 0191-491X .- 1879-2529. ; 63, s. 9-16
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Tidskriftsartikel (refereegranskat)abstract
- Previous research point to difficulties for teachers to interpret reading assessment data with regard to instructional decisions. This study explored Swedish primary teachers' use of assessments and recommendations, in order to be able to target individual needs. Eight teachers participated in a reading program and were interviewed in focus-group meetings. The analysis of teacher narratives stemming from assessment use resulted in three themes: Awareness of student learning, Changes in the organization of teaching, but not regarding individualized content and Strengthened teacher role, but modest professional growth. The themes indicated that the teachers had become aware of their students’ learning, had employed teaching based on informed decisions, and showed initial professional growth.However, the assessment details and the recommendations allowed for more adjustments than was evident in the teachers’ narratives. The results point to the relative difficulty of targeting individual needs in the general classroom education, and to the challenges of changing teaching practices.
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| 7. |
- Nordström, Thomas, Filosofie doktor i psykologi, 1977-, et al.
(författare)
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The potential of a forward-looking assessment and teaching system on students' reading gains
- 2019
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Ingår i: European Dyslexia Association Autumn Seminar, Växjö, Sweden, September 27-29.
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Konferensbidrag (refereegranskat)abstract
- PurposeHow can teachers optimize reading instruction in Swedish schools? This poster presents findings from two studies investigating A) grade 1-3 teachers’ use of a forward-looking assessment and teaching system (LegiLexi) and B), its effect on student reading gains in Grade 1. The purpose of study A was to support teachers with an assessment system which included teaching recommendations for individual students and to study how that support enabled teachers to individualize instruction. The purpose of study B was to gather evidence that such support is superior in relation to “teaching as usual”.MethodIn study A, focus group meetings of eight active LegiLexi teachers were used as to answer the question of the extent teachers managed to individualize instruction in their everyday practice. In study B, we randomly assigned schools to three conditions; full access to LegiLexi (8 schools/217 students), access only to part of LegiLexi (4 schools/86 students) and control (9 schools/208 students), following estimated effects of LegiLexi across three test occasions containing reading measures. Results/conclusionsIn study A, results revealed that teachers were supported by LegiLexi, and were able to individualize instruction primarily by creating dynamic reading groups of students. However, individualizing further proved challenging. In study B, findings revealed that the group with full access to LegiLexi improved their word decoding (d=1.79 vs 1.33 and 1.20) and reading comprehension the most (d=1.75 vs 1.45 and 1.16). Thus, the findings show promising results for Swedish schools of how to improve reading instruction by focusing on students’ individual needs.
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| 8. |
- Sameera, W M C, et al.
(författare)
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ONIOM(QM:AMOEBA09) Study on Binding Energies and Binding Preference of OH, HCO, and CH3 Radicals on Hexagonal Water Ice (I-h)
- 2017
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Ingår i: Journal of Physical Chemistry C. - : American Chemical Society (ACS). - 1932-7447 .- 1932-7455. ; 121:28, s. 15223-15232
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Tidskriftsartikel (refereegranskat)abstract
- We have combined the AMOEBA09 polarizable force field with the ONIOM(QM:MM) method to rationalize binding energies and binding preferences of the OH, HCO, and CH3 radicals on crystalline water ice (I-h). ONIOM(M062X:AMOEBA09) and ONIOM(wB97XD:AMOEBA) calculations suggest that the dangling hydrogen (d-H) or dangling oxygen (d-O) on the binding sites play an important role on the binding energies. Depending On the dangling nature at the binding site, a range of binding energies is found for the OH radical (0.67-0.20 eV), HCO radical (0.42--0.12 eV), and CH3 radical (0.26-0.11 eV). The binding energies of these radicals are larger in the presence of both d-H and d-O at the binding site. On the other hand, binding energies are weaker in the presence of only d-H or d-O at the binding site. The ONIOM(QM:AMOEBA09) methodology is found to be a useful approach to calculate binding energies of atoms, radicals, and molecules on I-h.
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| 9. |
- Senevirathne, Bethmini, 1982, et al.
(författare)
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Hydrogen atom mobility, kinetic isotope effects and tunneling on interstellar ices (I-h and ASW)
- 2017
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Ingår i: Molecular Astrophysics. - : Elsevier BV. - 2405-6758. ; 6, s. 59-69
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Tidskriftsartikel (refereegranskat)abstract
- Transitions of a single H atom between local minima on the surfaces of crystalline ice (I-h) and amorphous solid water (ASW) are studied theoretically in the temperature range 4-25 K. Binding energies, barrier heights, transition rate constants and the kinetic isotope effect (KIE) with and without tunneling are calculated. Harmonic transition state theory is used to obtain the transition rate constants and tunneling is treated with the Wigner tunneling correction, Eckart barrier correction and harmonic quantum transition state theory (HQTST). The classical binding energies are smaller on I-h (<47 meV) than on ASW (<89 meV). Also the classical barrier heights are smaller on I-h (<14 meV) than on ASW (<69 meV) and distributed over a range of energies, in line with previous experimental observations. Similarly the vibrationally adiabatic ground state (VAG) barrier heights are smaller on I-h (<7 meV) than on ASW (<54 meV). The surface morphology strongly influences the well depths. Tunneling increases some of the transition rate constants substantially but has a much smaller effect on others. The average KIE for I-h is higher than for ASW for the same range of barrier heights. (C) 2017 Elsevier B.V. All rights reserved.
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| 10. |
- Siverbo, Sven, 1970-, et al.
(författare)
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#metoo-management
- 2018
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Bok (övrigt vetenskapligt/konstnärligt)abstract
- För ett drygt år sedan inleddes #metoo-rörelsen, vilken påminner oss om att det finns brister i samhället även om allt ser bra ut på ytan. Mycket talar för att #metoo inte är en övergående fluga. Det handlar inte om en samordnad aktion med ett tydligt mål och det finns heller ingen ledare för rörelsen. #metoo är en självorganiserad rörelse, ett sätt att synliggöra det som under snart sagt hela mänsklighetens historia har förtigits, förnekats och bagatelliserats trots att alla har vetat. Den här rapporten belyser #metoo-rörelsens inverkan på organisationer ur ett managementperspektiv. Vi är intresserade av fenomenet #metoo-management, vilket vi definierar som organisationers arbete med att förebygga och hantera sexuella trakasserier som en följd av #metoo-rörelsen. Det första syftet med rapporten är att ta reda på om #metoo-management förekommer. Det andra syftet är att utforska hur organisationer arbetar med #metoo-management. Det tredje syftet är att förklara varför organisationer väljer att arbeta med #metoo- management på olika sätt. Baserat på intervjuer med företrädare för tio organisationer – i flera fall väldigt olika – har vi konstaterat att #metoo-rörelsen har gett upphov till #metoo- management. Mer precist handlar #metoo-management om flera olika åtgärder och aktiviteter. Organisationer har återupprepat och preciserat sina programförklaringar mot sexuella trakasserier. Programmen har fått förnyad spridning på arbetsplatserna och ytterligare åtgärder för programefterlevnad har vidtagits. Procedurer för klagomålshantering har utvecklats, utbildningar har initierats och riskfaktorer har identifierats och reducerats. Inte minst har förekomsten av problem med sexuella trakasserier inventerats. Något överraskande kunde vi notera att det inte fanns något exempel på att programmen mot sexuella trakasserier utvärderades och att det saknades planer för att minska beroendeförhållanden mellan chefer och anställda i de organisationer där dessa var betydande. Det är viktigt att betona att det finns betydande skillnader mellan organisationer i hur intensivt arbetet med #metoo-management har bedrivits. Skillnaderna förefaller bero på flera olika faktorer. En är att incidensen av sexuella trakasserier är olika och en annan att organisationer gör olika bedömningar av hur stor skada uppdagade fall skulle göra på arbetsgivarvarumärket. Ytterligare förklaringar till intensiteten i arbetet är skillnader i hur ambitiöst arbetet har varit innan #metoo- rörelsen och att det i vissa organisationer finns större kunskaper om riskfaktorer än i andra. Slutligen förefaller organisationens storlek och synlighet spela roll genom att de är mer påpassade och därför har större anledning att undvika problem som väcker negativ uppmärksamhet
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