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- Gustavsson, Carolina, et al.
(författare)
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Cerebrospinal fluid levels of insulin, leptin, and agouti-related protein in relation to BMI in pregnant women
- 2016
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Ingår i: Obesity. - : Wiley. - 1930-7381. ; 24:6, s. 1299-1304
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Tidskriftsartikel (refereegranskat)abstract
- ObjectiveDuring pregnancy, metabolic interactions must be adapted, though neuroendocrine mechanisms for increased food intake are poorly understood. The objective of this study was to characterize differences in insulin, leptin, and agouti-related protein (AgRP) levels in serum and cerebrospinal fluid (CSF) in pregnant women with normal weight (NW) and pregnant women with overweight (OW) or obesity (OB). Placenta as a source for increased peripheral AgRP levels during pregnancy was also investigated. MethodsWomen were recruited at admission for elective cesarean section. Insulin, AgRP, and leptin were measured in serum and CSF from 30 NW, 25 OW, and 21 OB at term. Serum during pregnancy and placenta at term were collected for further AgRP analysis. ResultsImmunohistology showed placental production of AgRP and serum AgRP levels increased throughout pregnancy. CSF AgRP, leptin, and insulin levels were higher in OW and OB than NW. Serum leptin and insulin levels were higher and AgRP lower in OB than NW. ConclusionsHigh serum AgRP levels might protect from the suppressive effects of leptin during pregnancy. Pregnant women with OB and OW might further be protected from the suppressive effect of leptin by high CSF AgRP levels. Evidence was found, for the first time, of human placental AgRP production mirrored by levels in the circulation.
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| 2. |
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| 3. |
- Andersson, Klas, 1975, et al.
(författare)
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Tillit och misstro i icke framgångsrika skolor
- 2018
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Ingår i: Skolan som politisk organisation 3:e uppl, Maria Jarl, Jon Pierre (red.). - : Gleerups Utbildning AB. - 9789140696984
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Bokkapitel (övrigt vetenskapligt/konstnärligt)
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| 4. |
- Andersson, Ulf, 1973-, et al.
(författare)
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Can Measurements of Online Behavior Predict Course Performance?
- 2016
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Ingår i: Proceedings of the 7th International Multi-Conference on Complexity, Informatics and Cybernetics: IMCIC 2016 and the 7th International Multi-Conference onSociety and Information Technologies: ICSIT 2016. - : International Institute of Informatics and Systemics. - 9781941763339 - 9781941763384 ; , s. 4-9
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Konferensbidrag (refereegranskat)abstract
- This article is a pilot study on the relationship between performance in online classes and behavior in online discussion forums. Measuring student activity on the discussion forum, the collected data is then analyzed and mapped to the performance of the students on the course. The student activity was dividedinto a number of parameters, and during the study these parameters were compared to the performance of the students.The significance of each parameter was also analyzed through a Kruskall-Wallis-test Overall there was a strong tendency thatstudents with more activity and engagement received higher grades. This is in the future useful for developing some kind of monitoring to identify and support students on the verge of failing the course.
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| 5. |
- Andersson, Ulf, 1973-, et al.
(författare)
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How well can completion of online courses be predicted using binary logistic regression?
- 2016
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Ingår i: Proceedings of IRIS39, Information Systems Research Seminar in Scandinavia, Ljungskile, August 7-10, 2016. - 9789187531385 ; , s. 1-12
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Konferensbidrag (övrigt vetenskapligt/konstnärligt)abstract
- This article uses binary logistic regression to create models for predicting course performance. The data used is the data-trail left by students activities on a discussion forum while attending an online course. The purpose of the study is to evalute how well models based on binary logistic regression can be used to predict course completion.Three sets of data was used for this. One set collected at the end of the course, one collected after 75% of the course and one set collected after half the course. The result of the study says that it's possible to design models with an accuracy of between 70% and 80% using these methods, regardless of what time is used.
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| 6. |
- Hall, Ulrika Andersson, et al.
(författare)
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Central and Peripheral Leptin and Agouti-Related Protein during and after Pregnancy in Relation to Weight Change.
- 2018
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Ingår i: Clinical endocrinology. - : Wiley. - 1365-2265 .- 0300-0664. ; 88:2, s. 263-271
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Tidskriftsartikel (refereegranskat)abstract
- To study changes of neuropeptides and adipokines in cerebrospinal fluid (CSF) and serum from pregnancy to post-pregnancy in relation to weight changes, fat mass and glucose metabolism.With high postpartum weight retention being a risk factor in future pregnancies and of life-long obesity we evaluated neuropeptide and adipokine changes in women who either gained weight or were weight stable.Women were followed for 5±1 years after pregnancy and divided into two groups, Weight-Stable and Weight-Gain, by weight change from start of pregnancy.Twenty-five women (BMI 27±5kg/m2 ) recruited at admission for elective caesarean section.CSF and serum levels of agouti-related protein (AgRP), leptin, and insulin, and serum levels of adiponectin and soluble leptin receptor were measured during and after pregnancy. These measurements were further related to fat mass and insulin sensitivity (HOMA-IR).S-AgRP levels during pregnancy were lower in the Weight-Stable group and a 1 unit increase in s-AgRP was associated with 24% higher odds of pertaining to the Weight-Gain group. After pregnancy, s-AgRP increased in the Weight-Stable group but decreased in the Weight-Gain group. Decreased transport of leptin into CSF during pregnancy was reversed by an increased CSF:serum leptin ratio after pregnancy. In women who returned to their pre-pregnancy weight, serum adiponectin increased after pregnancy and correlated negatively with HOMA-IR.S-AgRP concentration in late pregnancy may be one factor predicting weight change after pregnancy, and circulating AgRP may be physiologically important in the long-term regulation of body weight. This article is protected by copyright. All rights reserved.
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| 8. |
- Jarl, Maria, 1973, et al.
(författare)
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Därför lyckas vissa skolor bättre
- 2017
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Ingår i: Lärorik. Tidskrift för pedagogisk utveckling inom förskola och skola. Linköpings kommun. - 2001-1253. ; :2, s. 3-5
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Annan publikation (övrigt vetenskapligt/konstnärligt)
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