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| 2. |
- Andersson, Ulrika, 1977
(författare)
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2003 års publicistiska bokslut, del 2. Sportens olika sidor: männens och de manliga sporternas revir
- 2004
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Rapport (övrigt vetenskapligt/konstnärligt)abstract
- Männen dominerar sportens sidor, det visar en innehållsstudie av tre lokala morgontidningars sportrapportering från 2003. Fotboll och ishockey upptar en en majoritet av materialet i de tre tidningarna Piteå-tidningen, Västerbottens-kuriren och Östgöta Correspondenten. I de fall kvinnliga sporter uppmärksammas, är det oftast de manliga tränarna som intervjuas i artiklarna. Innehållsanalys genomförd i forskningsprojektet Publicistiska bokslut.
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| 3. |
- Andersson, Ulrika
(författare)
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Beta-glucose 1-phosphate interconverting enzymes in Lactococcus lactis: physiological role and regulation in maltose, trehalose and glucose metabolism
- 2002
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Doktorsavhandling (övrigt vetenskapligt/konstnärligt)abstract
- Lactic acid bacteria (LAB), including Lactococcus lactis, are abundant in nature. These bacteria convert carbohydrates into mainly lactate by a rather uncomplicated metabolism. An improved understanding of the physiological and genetical mechanisms involved in carbohydrate metabolism and its regulation will improve the industrial use of LAB. The aim of this study was to investigate the maltose and trehalose assimilating pathways in L. lactis. The maltose phosphorylase (MP) and beta-phosphoglucomutase (b-PGM) of L. lactis were characterised and shown to constitute the major maltose-degrading pathway in this bacterium. Furthermore, MP and b-PGM were shown to be present in many other strains of LAB belonging to the low G+C content LAB of the clostridial sub-branch of gram-positive bacteria. The MP-encoding gene, malP, was localised in an operon distinctive from that of the gene encoding b-PGM, pgmB. In addition, malR, encoding the maltose operon regulator (MalR), was localised downstream of malP. The presence of MalR was shown to be crucial for the synthesis of an ATP-dependent maltose translocation system. However, MP and b-PGM activity were not affected by a disruption of the MalR-encoding gene. Instead, synthesis of b-PGM has been shown to be exposed to carbon catabolite repression, which was also shown to be the case for MP. pgmB is located in the putative trehalose operon including the genes presumed to code for the trehalose-specific components of the phosphotransferase system transporting trehalose into the cells. Furthermore, directly upstream of pgmB, trePP was localised. This gene was shown to encode a novel phosphorylase, trehalose 6-phosphate phosphorylase (TrePP), catalysing the reversible Pi-dependent phosphorolysis of trehalose 6-phosphate to beta-glucose 1-phosphate and glucose 6-phosphate. TrePP was biochemically characterised and shown to be present in a few other species, mainly Enterococcus faecalis, of low G+C content LAB. The role of b-PGM in trehalose metabolism and in polysaccharide synthesis was assessed by disrupting its encoding gene. b-PGM was shown to be crucial for trehalose assimilation in L. lactis, while the b-PGM-deficient strain continued to grow with a tenfold decreased growth rate on maltose, compared to the wild-type strain. The b-PGM-deficient strain showed an enhanced production of polysaccharide, composed of alpha-1,4-linked glucose units when cultivated on maltose. It was suggested that this polysaccharide was a result from another metabolic pathway, resembling the maltodextrin system in Escherichia coli. Global regulatory circuits play a notable role when cells are adapting to environmental changes. A L. lactis mutant, TMB5003, was obtained by an unknown genetic event in the wild-type strain 19435. TMB5003 possessed an enhanced growth rate in glucose batch culture and a 1.5 times higher specific lactate productivity under non-limiting glucose conditions, compared to 19435. TMB5003 transported glucose by a non-saturating mode and the lactate dehydrogenase activity was twenty times higher in this strain compared to 19435. In conclusion, the results obtained for TMB5003, together with the characterisation of the initial disaccharide metabolism in L. lactis, may lead to improved industrial lactate production from LAB.
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| 4. |
- Andersson, Ulrika, et al.
(författare)
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Beta-glucose 1-phosphate-interconverting enzymes in maltose- and trehalose-fermenting lactic acid bacteria.
- 2002
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Ingår i: Environmental Microbiology. - : Wiley. - 1462-2920 .- 1462-2912. ; 4:2, s. 81-88
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Tidskriftsartikel (refereegranskat)abstract
- Maltose and trehalose catabolic pathways are linked through their common enzyme, beta-phosphoglucomutase, and metabolite, beta-glucose 1-phosphate, in Lactococcus lactis. Maltose is degraded by the concerted action of maltose phosphorylase and beta-phosphoglucomutase, whereas trehalose is assimilated by a novel pathway, including the recently discovered enzyme, trehalose 6-phosphate phosphorylase, and beta-phosphoglucomutase. In the present study, 40 strains of lactic acid bacteria were investigated for utilization of metabolic reactions involving beta-glucose 1-phosphate. All genera of the low G+C content lactic acid bacteria belonging to the clostridial subbranch of Gram-positive bacteria were represented in the study. The strains, which fermented maltose or trehalose, were investigated for beta-phosphoglucomutase, maltose phosphorylase and trehalose 6-phosphate phosphorylase activity, as indications of maltose and trehalose catabolic pathways involving beta-glucose 1-phosphate interconversions. Eighty per cent of all strains fermented maltose and, of these strains, 63% were shown to use a maltose phosphorylase/beta- phosphoglucomutase pathway. One-third of the strains fermenting trehalose were found to harbour trehalose 6-phosphate phosphorylase activity, and these were also shown to possess beta-phosphoglucomutase activity. Mainly L. lactis and Enterococcus faecalis strains were found to harbour the novel trehalose 6-phosphate phosphorylase/beta-phosphoglucomutase pathway. As lower beta-glucose 1-phosphate interconverting enzyme activities were observed in the majority of glucose-cultivated lactic acid bacteria, glucose was suggested to repress the synthesis of these enzymes in most strains. Thus, metabolic reactions involving the beta-anomer of glucose 1-phosphate are frequently found in both maltose- and trehalose-utilizing lactic acid bacteria.
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| 7. |
- Andersson, Ulrika, et al.
(författare)
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Epidermal growth factor receptor family (EGFR, ErbB2-4) in gliomas and meningiomas
- 2004
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Ingår i: Acta Neuropathologica. - : Springer Science and Business Media LLC. - 0001-6322 .- 1432-0533. ; 108:2, s. 135-142
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Tidskriftsartikel (refereegranskat)abstract
- Overexpression of epidermal growth factor receptor (EGFR, ErbB1) correlates with enhanced malignant potential of many human tumor types including glioblastoma multiforme. The significance of EGFR expression in meningiomas is, however, unclear. Reports regarding the other EGFR family members, ErbB2-4, in brain tumors are sparse. In this study, the expression of the EGFR family members was analyzed in relation to various parameters for the clinical importance of these receptors in 44 gliomas and 26 meningiomas. In gliomas, quantitative real-time reverse transcription (RT)-PCR revealed the highest EGFR mRNA expression in high-grade gliomas, while ErbB2 and ErbB3 mRNA were detected only in a few high-grade gliomas. In contrast, ErbB4 expression was most pronounced in low-grade gliomas. Immunohistochemistry showed significantly higher EGFR protein expression in high-grade gliomas compared to low-grade gliomas (P= 0.004). ErbB2 protein expression was mainly seen in high-grade gliomas. ErbB3 protein expression was low in all gliomas analyzed. ErbB4 protein expression was significantly higher in low-grade gliomas than in high-grade gliomas (P= 0.007). In meningiomas, quantitative real-time RT-PCR revealed expression of EGFR, ErbB2, and ErbB4 mRNA in the majority of the tumors. ErbB3 was detected in only one of the meningiomas analyzed. Immunohistochemistry demonstrated high ErbB2 protein expression in meningiomas. An intriguing observation in astrocytomas and oligodendrogliomas grade II, was a significantly decreased overall survival for patients with high EGFR protein expression (P= 0.04). The high ErbB4 expression in low-grade compared to high-grade gliomas might suggest that ErbB4 acts as a suppressor of malignant transformation in brain tumors, which is in line with previous studies in other tumor types.
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| 8. |
- Andersson, Ulrika, 1977
(författare)
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Framtidens tidningsläsare
- 2003
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Ingår i: Dagspresskollegiets PM-serie.
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Tidskriftsartikel (övrigt vetenskapligt/konstnärligt)abstract
- Studien visar att studenter tar del av prenumererad morgonpress i lägre utsträckning än andra samhällsgrupper. Empiriska data från Riks-SOM-undersökningarna.
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| 9. |
- Andersson, Ulrika
(författare)
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Hans (ord) eller hennes? : en könsteoretisk analys av straffrättsligt skydd mot sexuella övergrepp
- 2004
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Doktorsavhandling (övrigt vetenskapligt/konstnärligt)abstract
- The criminal justice system in modern western democracies is built on the rights of the one who is being accused of a crime, the subject of criminal responsibility, in relation to the repressive power held by the state. The entire system rests upon rules and principles, aiming at ensuring the rule of law as far as this subject is concerned. The subject is presumed to be autonomous and is set before the law according to the legal doctrine on criminal responsibility, presupposing that this subject makes free, rational choices. This thesis focuses the victim, or the one who may claim protection from a certain criminal provision: the subject of criminal protection. The main purpose is to explore and analyze the construction of this subject in criminal law in relation to sexual offences. The starting-point is that sex, as well as gender, is constructed, and that legal discourses contribute in doing so, while simultaneously producing the subjects set before the law. Drawing on the concept of discursive power put forward by Michel Foucault and Judith Butler’s constructivist theory of gender founded on the heterosexual matrix, the legal discourses are analyzed as such. The question is how these discourses construct, or produce the subject of criminal protection, more specifically regarding to body, sexuality and gender. It is argued that these discourses produce a subject with an open, accessible body and an accessible, passive sexuality, in other words a subject which is clearly feminine.
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