| 1. |
- Arvizu, Dan, et al.
(författare)
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Summary for Policy Makers: Intergovernmental Panel on Climate Change Special Report Renewable Energy Sources (SRREN)
- 2011
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Rapport (övrigt vetenskapligt/konstnärligt)abstract
- The Working Group III Special Report on Renewable Energy Sources and Climate Change Mitigation (SRREN) presents an assessment of the literature on the scientific, technological, environmental, economic and social aspects of the contribution of six renewable energy (RE) sources to the mitigation of climate change. It is intended to provide policy relevant information to governments, intergovernmental processes and other interested parties. This Summary for Policymakers provides an overview of the SRREN, summarizing the essential findings. The SRREN consists of 11 chapters. Chapter 1 sets the context for RE and climate change; Chapters 2 through 7 provide information on six RE technologies, and Chapters 8 through 11 address integrative issues.
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| 2. |
- Arvizu, Dan, et al.
(författare)
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Technical Summary
- 2011
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Ingår i: IPCC Special Report on Renewable Energy Sources and Climate Change Mitigation.
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Bokkapitel (refereegranskat)
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| 3. |
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| 4. |
- Giesecke, Thomas, et al.
(författare)
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Towards mapping the late Quaternary vegetation change of Europe.
- 2014
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Ingår i: Vegetation History and Archaeobotany. - : Springer Science and Business Media LLC. - 0939-6314 .- 1617-6278. ; 23:1, s. 75-86
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Tidskriftsartikel (refereegranskat)abstract
- The number of well-dated pollen diagrams in Europe has increased considerably over the last 30 years and many of them have been submitted to the European Pollen Database (EPD). This allows for the construction of increasingly precise maps of Holocene vegetation change across the continent. Chronological information in the EPD has been expressed in uncalibrated radiocarbon years, and most chronologies to date are based on this time scale. Here we present new chronologies for most of the datasets stored in the EPD based on calibrated radiocarbon years. Age information associated with pollen diagrams is often derived from the pollen stratigraphy itself or from other sedimentological information. We reviewed these chronological tie points and assigned uncertainties to them. The steps taken to generate the new chronologies are described and the rationale for a new classification system for age uncertainties is introduced. The resulting chronologies are fit for most continental-scale questions. They may not provide the best age model for particular sites, but may be viewed as general purpose chronologies. Taxonomic particularities of the data stored in the EPD are explained. An example is given of how the database can be queried to select samples with appropriate age control as well as the suitable taxonomic level to answer a specific research question.
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| 5. |
- Libanori, Rafael, et al.
(författare)
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Stretchable heterogeneous composites with extreme mechanical gradients
- 2012
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Ingår i: Nature Communications. - : Springer Nature. - 2041-1723. ; 3:1
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Tidskriftsartikel (refereegranskat)abstract
- Heterogeneous composite materials with variable local stiffness are widespread in nature, but are far less explored in engineering structural applications. The development of heterogeneous synthetic composites with locally tuned elastic properties would allow us to extend the lifetime of functional devices with mechanically incompatible interfaces, and to create new enabling materials for applications ranging from flexible electronics to regenerative medicine. Here we show that heterogeneous composites with local elastic moduli tunable over five orders of magnitude can be prepared through the site-specific reinforcement of an entangled elastomeric matrix at progressively larger length scales. Using such a hierarchical reinforcement approach, we designed and produced composites exhibiting regions with extreme soft-to-hard transitions, while still being reversibly stretchable up to 350%. The implementation of the proposed methodology in a mechanically challenging application is illustrated here with the development of locally stiff and globally stretchable substrates for flexible electronics.
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| 6. |
- Röthlisberger, André, et al.
(författare)
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Investigating the mechanism of collective bidirectional growth of carbon nanofiber carpets on metallic substrates
- 2013
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Ingår i: Carbon. - : Elsevier BV. - 0008-6223 .- 1873-3891. ; 63, s. 498-507
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Tidskriftsartikel (refereegranskat)abstract
- Bidirectional-growth of carbon nanofibers is a rare phenomenon found on free-standing catalyst particles, in contrast to the most commonly studied tip- and base-growth mechanisms for carbon nanostructures synthesized through thermal chemical vapor deposition. We reveal the underlying mechanisms of collective bidirectional growth in Ni x Pd 1-x -catalyzed carbon nanofiber carpets grown on a palladium substrate with varying nickel film thickness by monitoring the fiber growth evolution. The results show that the collective bidirectional growth is promoted and controlled by the chemical and physical restructuring of the sub-surface portion of the metal stack which undergoes micro-fragmentation as a result of the incorporation, diffusion, and precipitation of carbon. Carbon nanofiber growth can be controlled by engineering the catalyst-underlayer materials properties such as grain size, chemical composition and alloying. Since the determining factor whether carbon nanofibers or nanotubes are obtained is a strong function of catalyst size, the understanding of this growth mechanism can be transferred to the field of carbon nanotube synthesis. By keeping the grain size small enough to ensure carbon nanotube instead of carbon nanofiber growth, achieving dense, vertically aligned carbon nanotube carpets on metallic substrates might be possible, which is a prerequisite for carbon nanotube integration in integrated circuits.
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| 7. |
- Silajdzic, Edina, et al.
(författare)
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A Critical Evaluation of Inflammatory Markers in Huntington’s Disease Plasma
- 2013
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Ingår i: Journal of Huntington's disease. - 1879-6397. ; 2:1, s. 125-134
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Tidskriftsartikel (refereegranskat)abstract
- BACKGROUND: Huntington’s Disease (HD) is a hereditary, progressive neurodegenerative disorder characterised by both neurological and systemic symptoms. In HD, immune changes can be observed before the onset of overt clinical features raising the possibility that immune markers in plasma could be used to track disease progression. It has previously been demonstrated that a widespread, progressive innate immune response is detectable in plasma throughout the course of HD. OBJECTIVE: The aim of the present study was to investigate the potential of several components of innate immunity as plasma biomarkers in HD. METHODS: We utilised antibody-based detection technologies as well as mass spectrometric quantification, multiple reaction monitoring (MRM-MS). RESULTS: Levels of several markers previously described as altered in HD, such as clusterin, complement component 4, complement component 9 and α-2 macroglobulin did not differ between healthy controls and HD subjects as measured by Luminex, ELISA or MRM-MS. C-reactive protein was decreased in early HD, while the other immune markers tested were unaltered. CONCLUSIONS: Of the immune markers tested in this study, none showed potential to track with HD disease progression.
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| 8. |
- Traeger, Ulrike, et al.
(författare)
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HTT-lowering reverses Huntington's disease immune dysfunction caused by NF kappa B pathway dysregulation
- 2014
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Ingår i: Brain. - : Oxford University Press (OUP). - 1460-2156 .- 0006-8950. ; 137, s. 819-833
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Tidskriftsartikel (refereegranskat)abstract
- Huntington's disease is an inherited neurodegenerative disorder caused by a CAG repeat expansion in the huntingtin gene. The peripheral innate immune system contributes to Huntington's disease pathogenesis and has been targeted successfully to modulate disease progression, but mechanistic understanding relating this to mutant huntingtin expression in immune cells has been lacking. Here we demonstrate that human Huntington's disease myeloid cells produce excessive inflammatory cytokines as a result of the cell-intrinsic effects of mutant huntingtin expression. A direct effect of mutant huntingtin on the NF kappa B pathway, whereby it interacts with IKK gamma, leads to increased degradation of I kappa B and subsequent nuclear translocation of RelA. Transcriptional alterations in intracellular immune signalling pathways are also observed. Using a novel method of small interfering RNA delivery to lower huntingtin expression, we show reversal of disease-associated alterations in cellular function-the first time this has been demonstrated in primary human cells. Glucan-encapsulated small interfering RNA particles were used to lower huntingtin levels in human Huntington's disease monocytes/macrophages, resulting in a reversal of huntingtin-induced elevated cytokine production and transcriptional changes. These findings improve our understanding of the role of innate immunity in neurodegeneration, introduce glucan-encapsulated small interfering RNA particles as tool for studying cellular pathogenesis ex vivo in human cells and raise the prospect of immune cell-directed HTT-lowering as a therapeutic in Huntington's disease.
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