Cardiac beta1-adrenoceptor autoantibodies in human heart disease: rationale and design of the Etiology, Titre-Course, and Survival (ETiCS) Study.

• Evidence for a pathophysiologic relevance of autoimmunity in human heart disease has substantially increased over the past years. Conformational autoantibodies stimulating the cardiac beta1-adrenoceptor (beta1-aabs) are considered of importance in heart failure development and clinical pilot studies have shown their prognostic significance in human 'idiopathic' cardiomyopathy.

Subject headings

MEDICIN OCH HÄLSOVETENSKAP  -- Medicinska och farmaceutiska grundvetenskaper -- Fysiologi (hsv//swe)

MEDICAL AND HEALTH SCIENCES  -- Basic Medicine -- Physiology (hsv//eng)

Keyword

Antibody Specificity

immunology

Autoantibodies

immunology

Autoimmunity

immunology

Cardiomyopathy

Dilated

immunology

Humans

Immunoassay

methods

Multicenter Studies as Topic

Myocardial Infarction

immunology

Myocarditis

immunology

Myocardium

immunology

Patient Selection

Receptors

Adrenergic

beta-1

immunology

Research Design

Publication and Content Type

ref (subject category)

art (subject category)