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| 2. |
- Lindblad-Toh, Kerstin, et al.
(författare)
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Genome sequence, comparative analysis and haplotype structure of the domestic dog.
- 2005
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Ingår i: Nature. - : Springer Science and Business Media LLC. - 1476-4687 .- 0028-0836. ; 438:7069, s. 803-19
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Tidskriftsartikel (refereegranskat)abstract
- Here we report a high-quality draft genome sequence of the domestic dog (Canis familiaris), together with a dense map of single nucleotide polymorphisms (SNPs) across breeds. The dog is of particular interest because it provides important evolutionary information and because existing breeds show great phenotypic diversity for morphological, physiological and behavioural traits. We use sequence comparison with the primate and rodent lineages to shed light on the structure and evolution of genomes and genes. Notably, the majority of the most highly conserved non-coding sequences in mammalian genomes are clustered near a small subset of genes with important roles in development. Analysis of SNPs reveals long-range haplotypes across the entire dog genome, and defines the nature of genetic diversity within and across breeds. The current SNP map now makes it possible for genome-wide association studies to identify genes responsible for diseases and traits, with important consequences for human and companion animal health.
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| 3. |
- Kühn, Ingolf, et al.
(författare)
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MACIS: Minimisation of and Adaptation to Climate Change Impacts on BiodiverSity
- 2008
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Ingår i: GAIA. - 0940-5550. ; 17:4, s. 393-395
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Tidskriftsartikel (refereegranskat)abstract
- The recently finished EU funded project MACIS reviewed observed and projected climate change impacts on biodiversity. It assessed mitigation and adaptation options. It also reviewed and developed methods to assess future impacts of climate change on biodiversity including the identification of policy options to prevent and minimise these impacts.
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| 4. |
- Muyldermans, G, et al.
(författare)
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External quality assessment for molecular detection of Bordetella pertussis in European laboratories.
- 2005
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Ingår i: Journal of Clinical Microbiology. - 0095-1137 .- 1098-660X. ; 43:1, s. 30-35
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Tidskriftsartikel (refereegranskat)abstract
- Although the PCR for the detection of Bordetella pertussis is routinely performed in diagnostic laboratories, no quality assessment program has so far been described. We report on the results obtained with two external quality assessment proficiency panels sent to European laboratories. The first proficiency panel contained a series of dilutions of three previously characterized B. pertussis clinical isolates and two negative controls. No false-positive results were reported by six laboratories providing seven data sets. The reported limits of detection of the three B. pertussis strains varied between 4 and 4,000, 9 and 9,000, and 3 and 30,000 CFU/ml, respectively. The second proficiency panel, composed of a series of dilutions of reference strains of B. pertussis, B. holmesii, B. hinzii, and B. bronchiseptica, as well as negative controls, was sent to nine laboratories. One laboratory reported a negative result for a sample and reported a B. parapertussis-positive sample to be positive for B. pertussis. By using the B. pertussis-specific target gene pertactin, one laboratory detected B. pertussis with 100% specificity. All other laboratories, which used IS481-based assays, reported positive results for the samples containing B. holmesii and B. bronchiseptica, species that have occasionally been recovered from human respiratory samples. These data show that the choice of the target gene is particularly critical for the species specificity of B. pertussis PCR assays.
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| 5. |
- Aggett, P J, et al.
(författare)
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PASSCLAIM - Consensus on criteria
- 2005
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Ingår i: European Journal of Nutrition. - : Springer Science and Business Media LLC. - 1436-6215 .- 1436-6207. ; 44:Supplement 1, s. 5-30
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Tidskriftsartikel (refereegranskat)
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| 6. |
- Delheusy, M., et al.
(författare)
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X-ray investigation of subsurface interstitial oxygen at Nb/oxide interfaces
- 2008
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Ingår i: Applied Physics Letters. - : AIP Publishing. - 0003-6951 .- 1077-3118. ; 92:10
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Tidskriftsartikel (refereegranskat)abstract
- We have investigated the dissolution of a natural oxide layer on a Nb(110) surface upon heating, combining x-ray reflectivity, grazing incidence diffuse scattering, and core-level spectroscopy. The natural oxide reduces after heating to 145 degrees C partially from Nb2O5 to NbO2, and an enrichment in subsurface interstitial oxygen by similar to 70% in a depth of 100 A is observed. After heating to 300 degrees C, the oxide reduces to NbO and the surplus subsurface oxygen gets dissolved into the bulk. Our approach can be applied for further investigation of the effect of subsurface interstitial oxygen on the performance of niobium rf cavities. (C) 2008 American Institute of Physics. (C) 2008 American Institute of Physics.
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| 7. |
- Przyrembel, Hildegard, et al.
(författare)
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From innovation to implementation.
- 2005
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Ingår i: Adv Exp Med Biol. - 0065-2598. ; 569, s. 49-53
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Tidskriftsartikel (övrigt vetenskapligt/konstnärligt)abstract
- Requirements for the safety and nutritional adequacy of infant formula are set by legislation and aim for the best possible substitute for human milk with regard to growth, development and biological effects. This is, however, a continuous process and has to be supported by science-driven innovative activities of manufacturers and be confirmed by adequate clinical studies performed according to agreed standards.
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