| 1. |
- Adrianson, Lillemor, et al.
(författare)
-
Cultural influences upon health, affect, self-esteem and impulsiveness : An Indonesian-Swedish comparison
- 2013
-
Ingår i: International Journal of Research Studies in Psychology. - : Consortia Academia Publishing. - 2243-7681 .- 2243-769X. ; 2:3, s. 25-44
-
Tidskriftsartikel (refereegranskat)abstract
- The present study examines several personal attributes that distinguish the personal profiles of individuals, from Indonesian and Swedish cultures, according to self-reports of positive and negative effect, stress and energy, self-esteem, hospital anxiety and depression, dispositional optimism and health. Indonesian participants expressed both more PA and more NA than Swedish participants but less stress and a higher energy-stress quotient than the Swedish participants. Additionally, the former expressed a higher level of optimism and self-esteem, but also more depression, and less impulsiveness than the latter. Younger participants expressed less positive affect and more negative affect and impulsiveness than older participants who expressed both more stress and a higher energy stress quotient. Regression analyses indicated that PA was predicted by optimism and health whereas NA was predicted by anxiety and depression and impulsiveness and counter predicted by health. The present findings are discussed according to the notion of emotional regulation according to which individuals differ in their use of emotion regulation strategies such as reappraisal and suppression, and these individual differences have implications for affect, well-being, and social relationships.
|
|
| 2. |
- Andersson Arntén, Ann-Christine, 1954, et al.
(författare)
-
The Affective Profile Model in Swedish Police Personnel: Work Climate and Motivation
- 2014
-
Ingår i: 26th Association for Psychological Science Annual Convention. San Francisco, California, USA.
-
Konferensbidrag (övrigt vetenskapligt/konstnärligt)abstract
- ABSTRACT The study showed that police personnel perceive the work environment depending on their affective profile, these perceptions in turn influence motivation differently for each profile. A positive view on the work environment and intrinsic motivation being related to an affective profile depicted as high positive affect and low negative affect. SUPPORTING SUMMARY Background: The work climate (i.e., employees’ perceptions of how they are treated and managed in their organization) is important when the organizations try to motivate employees to allocate and enhance their efforts into their work. The affective profile model offers something unique over and above the single dimensional framework of affectivity by taking into account how positive (PA) and negative affectivity (NA) interact; these interaction can be used to investigate individual differences in perceptions about the working climate and its influences on motivation. Method: We used the Positive Affect, Negative Affect Schedule to categorize police personnel (N = 595) in four affective profiles: Self-fulfilling (high PA and low NA), low affective (low PA and low NA), high affective (high PA and high NA), and self-destructive (low PA and high NA). Individuals’ perceptions of the work climate were assessed using the Learning Climate Questionnaire which measures seven dimensions: management relations and style, time, autonomy and responsibility, team style, opportunities to develop, guidelines on how to do the job, and contentedness. Finally, we used the Situational Motivation Scale to measure four motivation dimensions: intrinsic motivation, external regulation, identified regulation, and amotivation. Results: Results show that self-fulfilling individuals scored higher on all work climate compared to the other three groups. Regarding motivation, profiles with high PA (self-fulfilling and high affective) scored higher in internal motivation and identified regulation than the profiles with low PA. Self-destructive individuals scored higher in amotivation compared to the other three profiles. Different aspects of the work climate were related to each motivation dimension among affective profiles. Conclusions: These results suggest that individuals may react to the work environment depending on their affective profile. Moreover, how the work environment influences police personnel’s motivation is also a function of the individuals’ distinct affective profile.
|
|
| 3. |
- Archer, Trevor, 1949, et al.
(författare)
-
Clinical staging in the pathophysiology of psychotic and affective disorders: facilitation of prognosis and treatment.
- 2010
-
Ingår i: Neurotoxicity research. - : Springer Science and Business Media LLC. - 1476-3524 .- 1029-8428. ; 18:3-4, s. 211-28
-
Tidskriftsartikel (refereegranskat)abstract
- The prevailing utility, and indeed necessity, of clinical staging models applied in considerations of neuropsychiatric disease progressions is discussed from the perspectives of schizophrenia spectrum disorders and affective disorders, cannabis in schizopsychotic disorder, incidences of affect and psychosis, staging disorders in aging and the indices and prevalence of apathy. There would appear to be a strong current consensus that the pursuit of clinical staging of these and other brain disease states has contributed a systematic conceptual instrument to facilitate the better understanding, diagnosis, prognosis and treatment as derived from a multitude of genetic predispositions, symptoms and syndromes, early-onset and prodromal phases, recurrences and relapses, that have complicated the situation of the patient. Through a staging determination of the disorder, elements of diagnosis will describe the progression of symptoms/syndromes through pre-onset, prodromal, first-episode, recurrences and relapses, and treatment resistance thereby facilitating the eventual prognosis, intervention alternatives and treatment. This approach varies from observations of individuals at early stages of development (infancy, childhood, adolescece) to early middle age, in the case of diseases expressed through the aging processes. Essentially, the major contribution of the staging model may lie in the early identification, diagnosis, and treatments of disorders that afflict the brain and central nervous system.
|
|
| 4. |
- Archer, Trevor, 1949, et al.
(författare)
-
Delayed Exercise-Induced Functional and Neurochemical Partial Restoration Following MPTP
- 2012
-
Ingår i: Neurotoxicity research. - : Springer Science and Business Media LLC. - 1029-8428 .- 1476-3524. ; 21:2, s. 210-221
-
Tidskriftsartikel (refereegranskat)abstract
- In two experiments, MPTP was administered to C57/BL6 mice according to a single-dose weekly regime (MPTP: 1 x 30 mg/kg on the fifth day of the week, Friday, over 4 weeks) with vehicle group (Vehicle: 1 x 5 ml/kg) treated concurrently. Exercise schedules (delayed) were introduced either at the beginning of the week after the second MPTP injection (MPTP + Exercise(2) group), or at the beginning of the week after the fourth MPTP injection (MPTP + Exercise(4) group). Wheel-running was provided on the first 4 days of each week (Monday-Thursday) more than 30-min periods. In Experiment I, wheel-running exercise was introduced either after 2 or 4 weeks after MPTP/Vehicle. MPTP and Vehicle groups not provided access to the running wheels were placed in single cages within the wheel-running room over 30-min concomitantly with the wheel-running groups. In Experiment II, wheel-running exercise was introduced 2 weeks after MPTP/Vehicle but a no-exercise control group with non-revolving wheel included (MPTP-Wheel). In both experiments, spontaneous motor activity tests during 60-min intervals were performed at the end (Fridays) of weeks 1, 2, 3, 4, 6, 8, and 10, where the week on which the first injection of MPTP was the first week; in the case of weeks 1-4, this was immediately before MPTP/Vehicle injections. It was observed that the introduction of the exercise schedule after the second MPTP injection, but not after the fourth injection, restored motor activity that had been markedly elevated by the end of the tenth week. Subthreshold administration of l-dopa tests was performed after the spontaneous motor activity tests 6, 8 and 10; these indicated significant effects of exercise, MPTP + Exercise(2) group, on Tests 6 and 8, but not Test 10. The physical exercise schedule in that group also showed markedly attenuated loss of dopamine (DA). Restoration of MPTP-induced motor activity deficits and DA loss was a function of the point at which exercise was introduced, in the present case after two administrations of the neurotoxin. In Experiment II, physical exercise markedly attenuated the hypokinesic effect of MPTP in the exercise condition, MPTP-exercise, but not in the non-exercise conditions, MPTP-Cage and MPTP-Wheel, for both spontaneous motor activity and l-dopa-induced activity. MPTP-induced loss of DA was also attenuated by exercise.
|
|
| 5. |
- Archer, Trevor, 1949, et al.
(författare)
-
Drug abuse neurotoxicity: alcohol and nicotine as developmental stressors
- 2013
-
Ingår i: Handbook of Neurotoxicity. - : Springer. - 9781461458357 ; , s. 2003-2023
-
Bokkapitel (refereegranskat)abstract
- Drugs of abuse have the property of inducing adverse health complications, not least neurotoxicity under conditions where both the environmental conditions and activity states associated with their intake may strongly enhance drug toxicity, thereby causing life-threatening health complications and tragedy for relations and caregivers. While both chronic alcohol and/or nicotine abuse induce a variety of neuropathological effects, including damage to the brain, the extent of damage and disruption observed in the developing brain and CNS is a considerable affliction for the affected individuals. On the basis of laboratory and clinical studies, the potential of chemicals, including therapeutic and abused agents, to induce neurotoxic effects has been assessed, with considerations of abuse drugs neurotoxicity encompassing several factors that may accelerate and complicate prevailing conditions; the type and influence of environmental conditions, the presence of daily habits such as coffee breaks/smoking breaks, nutritional status, and neuroimmune system mobilization. Abuse neurotoxicity at several stages of early development, alcohol neurotoxicity, nicotine neurotoxicity, and combinations of alcohol-nicotine neurotoxicity present a threatening scenario of two compounds, benefitting from legality and availability that nevertheless have such potential for destruction over multiple domains, particularly in the undeveloped brain.
|
|
| 6. |
- Archer, Trevor, 1949
(författare)
-
Effects of Exogenous Agents on Brain Development: Stress, Abuse and Therapeutic Compounds.
- 2010
-
Ingår i: CNS neuroscience & therapeutics. - : Wiley. - 1755-5949 .- 1755-5930.
-
Tidskriftsartikel (refereegranskat)abstract
- SUMMARY The range of exogenous agents likely to affect, generally detrimentally, the normal development of the brain and central nervous system defies estimation although the amount of accumulated evidence is enormous. The present review is limited to certain types of chemotherapeutic and "use-and-abuse" compounds and environmental agents, exemplified by anesthetic, antiepileptic, sleep-inducing and anxiolytic compounds, nicotine and alcohol, and stress as well as agents of infection; each of these agents have been investigated quite extensively and have been shown to contribute to the etiopathogenesis of serious neuropsychiatric disorders. To greater or lesser extent, all of the exogenous agents discussed in the present treatise have been investigated for their influence upon neurodevelopmental processes during the period of the brain growth spurt and during other phases uptill adulthood, thereby maintaining the notion of critical phases for the outcome of treatment whether prenatal, postnatal, or adolescent. Several of these agents have contributed to the developmental disruptions underlying structural and functional brain abnormalities that are observed in the symptom and biomarker profiles of the schizophrenia spectrum disorders and the fetal alcohol spectrum disorders. In each case, the effects of the exogenous agents upon the status of the affected brain, within defined parameters and conditions, is generally permanent and irreversible.
|
|
| 7. |
- Archer, Trevor, 1949, et al.
(författare)
-
Effects of physical exercise on depressive symptoms and biomarkers in depression
- 2014
-
Ingår i: CNS & Neurological Disorders. - Bussum : Bentham Science Publishers. - 1871-5273 .- 1996-3181. ; 13:10, s. 1640-1653
-
Tidskriftsartikel (refereegranskat)abstract
- Regular physical exercise/activity has been shown repeatedly to promote positive benefits in cognitive, emotional and motor domains concomitant with reductions in distress and negative affect. It exerts a preventative role in anxiety and depressive states and facilitates psychological well-being in both adolescents and adults. Not least, several meta-analyses attest to improvements brought about by exercise. In the present treatise, the beneficial effects of exercise upon cognitive, executive function and working memory, emotional, self-esteem and depressed mood, motivational, anhedonia and psychomotor retardation, and somatic/physical, sleep disturbances and chronic aches and pains, categories of depression are discussed. Concurrently, the amelioration of several biomarkers associated with depressive states: hypothalamic-pituitary-adrenal (HPA) axis homeostasis, anti-neurodegenerative effects, monoamine metabolism regulation and neuroimmune functioning. The notion that physical exercise may function as "scaffolding" that buttresses available network circuits, anti-inflammatory defences and neuroreparative processes, e.g. brain-derived neurotrophic factor (BDNF), holds a certain appeal. © 2014 Bentham Science Publishers.
|
|
| 8. |
- Archer, Trevor, 1949, et al.
(författare)
-
Epigenetics and biomarkers in the staging of neuropsychiatric disorders.
- 2010
-
Ingår i: Neurotoxicity research. - : Springer Science and Business Media LLC. - 1476-3524 .- 1029-8428. ; 18:3-4, s. 347-66
-
Tidskriftsartikel (refereegranskat)abstract
- Epigenetics, or alterations in the phenotype or gene expression due to mechanisms other than changes in the underlying DNA sequence, reflects the sensitivity and responsiveness of human and animal brains in constantly varying circumstances regulating gene expression profiles that define the biomarkers and present the ultimate phenotypical outcomes, such as cognition and emotion. Epigenetics is associated with functionally relevant alterations to the genome in such a fashion that under the particular conditions of early, adolescent, and adult life, environmental signals may activate intracellular pathways that remodel the "epigenome," triggering changes in gene expression and neural function. Thus, genetic influences in neuropsychiatric disorders that are subject to clinical staging, epigenetics in schizophrenia, epigenetic considerations in the expression of sensorimotor gating resulting from disease conditions, biomarkers of drug use and addiction, current notions on the role of dopamine in schizophrenia spectrum disorders, and the discrete interactions of biomarkers in persistent memory were to greater or lesser extents reflected upon. The relative contributions of endophenotypes and epistasis for mediating epigenetic phenomena and the outcomes as observed in the analysis of biomarkers appear to offer a multitude of interactive combinations to further complicate the labyrinthine machinations of diagnosis, intervention, and prognosis.
|
|
| 9. |
- Archer, Trevor, 1949, et al.
(författare)
-
Epigenetics in Developmental Disorder: ADHD and Endophenotypes.
- 2011
-
Ingår i: Journal of genetic syndrome & gene therapy. - 2157-7412. ; 2:104
-
Tidskriftsartikel (refereegranskat)abstract
- Heterogeneity in attention-deficit/hyperactivity disorder (ADHD), with complex interactive operations of genetic and environmental factors, is expressed in a variety of disorder manifestations: severity, co-morbidities of symptoms, and the effects of genes on phenotypes. Neurodevelopmental influences of genomic imprinting have set the stage for the structural-physiological variations that modulate the cognitive, affective, and pathophysiological domains of ADHD. The relative contributions of genetic and environmental factors provide rapidly proliferating insights into the developmental trajectory of the condition, both structurally and functionally. Parent-of-origin effects seem to support the notion that genetic risks for disease process debut often interact with the social environment, i.e., the parental environment in infants and young children. The notion of endophenotypes, markers of an underlying liability to the disorder, may facilitate detection of genetic risks relative to a complex clinical disorder. Simple genetic association has proven insufficient to explain the spectrum of ADHD. At a primary level of analysis, the consideration of epigenetic regulation of brain signalling mechanisms, dopamine, serotonin, and noradrenaline is examined. Neurotrophic factors that participate in the neurogenesis, survival, and functional maintenance of brain systems, are involved in neuroplasticity alterations underlying brain disorders, and are implicated in the genetic predisposition to ADHD, but not obviously, nor in a simple or straightforward fashion. In the context of intervention, genetic linkage studies of ADHD pharmacological intervention have demonstrated that associations have fitted the "drug response phenotype," rather than the disorder diagnosis. Despite conflicting evidence for the existence, or not, of genetic associations between disorder diagnosis and genes regulating the structure and function of neurotransmitters and brain-derived neurotrophic factor (BDNF), associations between symptoms-profiles endophenotypes and single nucleotide polymorphisms appear reassuring.
|
|
| 10. |
- Archer, Trevor, 1949, et al.
(författare)
-
Epigenetics in neuropsychiatry
- 2011
-
Ingår i: Omics : Biomedical Perspectives and Applications / edited by Debmalya Barh, Kenneth Blum, Margaret A. Madigan. - : CRC Press. - 9781439850084 ; , s. 511-532
-
Bokkapitel (övrigt vetenskapligt/konstnärligt)abstract
- The notion of epigenetics offers a putative interface between genetic and environmental factors that interact to provide the phenotypic. The impact of the environment on gene expression (epigenetics) and the convergence of genes and environment along common biological pathways induce greater effects than either those of genes or environment in isolation. Transgenerational epigenetic inheritance, i.e. the survival of epigenetic modifications over generations, provides a process through maternal nurturing behavior may affect the development and health of the offspring. Epigenetic operations regulate depressive disorders and schizophrenia spectrum disorders as well as interventional strategies. The present account examines epigenetic influences to inherited characteristics subjected to conditions of prenatal or early-life adversity that produce the eventual expressions of these disorders, and such developmental disorders as Prader-Willi syndrome. The essential role of nutrition is central: epigenetic regulation encompasses alterations of genetic material that do not affect the DNA nucleotide sequence, but rather include DNA methylation patterns, chromatin structure, histone codes, and noncoding small RNAs. Influences such as epigenetic interactions on DNA damage response and DNA repair may yet provide insights facilitating diagnosis and understanding of progression and intervention
|
|
