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- Ekblad, E., et al.
(författare)
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Neuropeptides in the human appendix - Distribution and motor effects
- 1989
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Ingår i: Digestive Diseases and Sciences. - 0163-2116. ; 34:8, s. 1217-1230
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Tidskriftsartikel (refereegranskat)abstract
- At present our knowledge of enteric peptide-containing neurons in man is limited. In this study we have used human appendices removed at surgery to examine the peptidergic innervation by immunocytochemistry, immunochemistry, and pharmacological in vitro experiments. Immunocytochemistry revealed a variety of peptide-containing nerve fiber populations in the human appendix. VIP/PHI-, VIP/PHI/NPY-, SP/NKA-, galanin-, and enkephalin-containing nerve fibers were numerous; CGRP- and GRP- containing nerve fibers were moderate in number, while only scattered NPY-, enkephalin/BAM-, and somatostatin-containing nerve fibers could be found. No CCK-, dynorphin A-, or dynorphin B- immunoreactive nerve fibers could be detected. The coexistence of VIP/PHI, SP/NKA, and enkaphalin/BAM can be anticipated from the known sequence of their respective precursors. However, the coexistence of VIP/PHI and NPY was unexpected but corroborates previous observations in other species. Interestingly, SP and CGRP did not seem to coexist in nerve fibers of the human appendix. Immunochemistry (RIA and HPLC) confirmed the presence of VIP, NPY, SP, galanin, CGRP, GRP, enkephalin, and somatostatin. Motor activity studies suggest that acetylcholine plays a major role in the electrically evoked contractions, since atropine suppressed these contractions. Galanin (10-8-10-6 M) and GRP (10-9-10-7 M) caused concentration-dependent contractions that were unaffected by tetrodotoxin and thus probably reflect a direct action on smooth muscle receptors. GRP (10-9 M) enhanced the electrically induced cholinergic contraction (to 193±24%), while met-enkephalin (10-6 M) reduced it (to 54±6%). Both peptides failed to affect the contractile response to exogenous acetylcholine and probably act to modulate the release of acetylcholine. NPY, VIP, CGRP, SP, and somatostatin failed to induce contraction or to affect the electrically evoked contractions.
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| 3. |
- Arnbjörnsson, E., et al.
(författare)
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Computed tomography of ano-rectal anomalies : Correlation between radiologic findings and clinical evaluation of faecal incontinence
- 1989
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Ingår i: Acta Radiologica. - : SAGE Publications. - 0284-1851 .- 1600-0455. ; 30:1, s. 25-28
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Tidskriftsartikel (refereegranskat)abstract
- Computed tomography (CT) was performed in 9 patients with faecal incontinence more than 8 years after rectoplasty for high imperforate anus. The radiologic findings were correlated with the clinical evaluation of faecal incontinence. No statistically significant correlation was found between function and anatomic findings as demonstrated by CT. Thus, although CT demonstrates the post-operative anatomy in a detailed way, the information does not seem to be directly applicable when selecting the type of reoperation for faecal incontinence.
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| 5. |
- Arnbjörnsson, E.
(författare)
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Invagination versus simple ligation of the caecal tip with reference to the strength of the caecal closure. An experimental study in the rat.
- 1986
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Ingår i: Annales Chirurgiae et Gynaecologiae. - 0355-9521. ; 75:3, s. 180-182
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Tidskriftsartikel (refereegranskat)abstract
- In an experimental model using the rat, the role of invagination and double invagination for efficient closure of the caecum was studied. A standardized opening of the tip of the caecum was closed in three different ways, thus placing the animals in three groups. I: Closed with simple ligation. II: Closed with simple ligation and a purse-string suture invagination. III: Closed with simple ligation and a purse-string suture and a Z-suture causing double invagination. The caecum was filled with methylene blue and obstructed by a balloon catheter introduced via a caecostomy. Pressure inside the obstructed caecum was measured through a channel opening at the tip of the catheter. The pressure was increased with 4 cm of water every 10 minutes. The maximal pressure reached before leakage of methylene blue from the caecal closure or a drop in pressure in the lumen, was seen to be significantly higher in the groups with invagination and double invagination of the caecal closure, respectively, when compared with those with simple ligation only. The experimental data suggest that the invagination is important for secure closure of the caecal wall.
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| 6. |
- Arnbjörnsson, E.
(författare)
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Normal and pathological bowel sound patterns.
- 1986
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Ingår i: Annales Chirurgiae et Gynaecologiae. - 0355-9521. ; 75:6, s. 314-318
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Tidskriftsartikel (refereegranskat)abstract
- The purpose of this study was to determine the usefulness of auscultation of bowel sounds in evaluating patients with total and subtotal small intestinal obstruction and immediately after operation. The study was based on ten healthy volunteers, seven patients with documented mechanical obstruction, one patient with chronic subtotal mechanical obstruction and twelve patients undergoing an emergency laparotomy. Bowel sounds varied markedly in all individuals studied. The most striking finding in mechanical obstruction was the regular occurrence of clustered bowel sounds. These were defined as 3-10 regular sounds, occurring one every five seconds, preceded and followed by at least one minute of silence. The associated periods of quiescent motor activity may account for the unexpectedly reduced frequency and motility index after a meal in obstructed patients compared with normal subjects. The different bowel sound patterns occurred in the patient with subtotal mechanical obstruction before and after a meal respectively i.e. infrequent and low-amplitude bowel sounds and clustered bowel sounds. The technique is probably not more sensitive than radiological procedures, and the abnormalities that are detected by an auscultation of bowel sounds are not specific.
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