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Träfflista för sökning "WFRF:(Aro P.) srt2:(2005-2009)"

Sökning: WFRF:(Aro P.) > (2005-2009)

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  • Vainonen, Julia P., et al. (författare)
  • Light regulation of CaS, a novel phosphoprotein in the thylakoid membrane of Arabidopsis thaliana
  • 2008
  • Ingår i: The FEBS Journal. - : Wiley. - 1742-464X .- 1742-4658. ; 275:8, s. 1767-1777
  • Tidskriftsartikel (refereegranskat)abstract
    • Exposure of Arabidopsis thaliana plants to high levels of light revealed specific phosphorylation of a 40 kDa protein in photosynthetic thylakoid membranes. The protein was identified by MS as extracellular calcium-sensing receptor (CaS), previously reported to be located in the plasma membrane. By confocal laser scanning microscopy and subcellular fractionation, it was demonstrated that CaS localizes to the chloroplasts and is enriched in stroma thylakoids. The phosphorylation level of CaS responded strongly to light intensity. The light-dependent thylakoid protein kinase STN8 is required for CaS phosphorylation. The phosphorylation site was mapped to the stroma-exposed Thr380, located in a motif for interaction with 14-3-3 proteins and proteins with forkhead-associated domains, which suggests the involvement of CaS in stress responses and signaling pathways. The knockout Arabidopsis lines revealed a significant role for CaS in plant growth and development. © 2008 The Authors.
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  • Bolling-Sternevald, E, et al. (författare)
  • Do gastrointestinal symptoms fluctuate in the short-term perspective? The Kalixanda study
  • 2008
  • Ingår i: Digestive diseases (Basel, Switzerland). - : S. Karger AG. - 1421-9875 .- 0257-2753. ; 26:3, s. 256-263
  • Tidskriftsartikel (refereegranskat)abstract
    • <i>Background/Aim:</i> Short-term fluctuation of gastrointestinal symptoms in the general population is largely unknown. We aimed to determine gastrointestinal symptom fluctuation in an random adult population using a validated questionnaire assessing gastrointestinal symptoms. <i>Methods:</i> A representative sample (n = 2,860) of the population (n = 21,610, 20–81 years of age; mean age 50.4 years) in Northern Sweden was studied. The subjects were asked to complete the questionnaire on two occasions [mean 2.5 months (range 1–6)], firstly via mail and secondly at a visit to the clinic. An upper endoscopy was performed after the last assessment of symptoms. <i>Results:</i> 2,122 individuals (74.2%) completed the initial questionnaire; 1,001 of these (mean age 54.1 years, 48.8 males) completed the second questionnaire. On the first occasion, 40% of the subjects were symptom-free (20.2%) or could not be classified according to their symptom pattern, of those with symptoms 39% reported troublesome reflux symptoms, 40% dyspeptic symptoms and 30% irritable bowel symptoms. Symptom overlap occurred in more than two thirds of the subjects. At the second visit 75% of the subjects who had reported dyspeptic complaints still reported such complaints. <i>Conclusions:</i> In this population-based study, gastrointestinal symptoms were common. Some symptom fluctuation occurred in the shorter term, but troublesome gastrointestinal complaints remained in approximately 90% of subjects over a 1–6-month period.
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