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- Burstein, F., et al.
(författare)
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Context-aware mobile agents for decision-making support in healthcare emergency applications
- 2005
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Ingår i: Proceedings of the Workshop on Context Modeling and Decision Support. - : CEUR Workshop Proceedings.
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Konferensbidrag (refereegranskat)abstract
- This paper applies agents to the highly dynamic and variable context of healthcare emergency decision-support domain. More specifically we advocate the use of mobile agents to support the deployment of an ambulance service in real-time. We presented an implementation of the proposed agent based architecture, which was based on the specific functional and non-functional application requirements set out based on thorough analysis of literature. We also created an illustrative emergency scenario in order to demonstrate the validity and feasibility of our proposed model. From the evaluation of the implementation we were able to identify some of the major technical advantages it has to offer as well as challenges one needs to address in similar attempts. We choose mobile agents as the key enabling technology because they offer a single, general framework in which large-scale distributed real-time decision support applications can be implemented more efficiently. Healthcare was chosen as the target application domain to emphasize both the benefits derived from the exploitation of mobile agent paradigm in this domain as well as to demonstrate the benefits of the proposed approach in the highly uncertain context.
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| 2. |
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| 3. |
- Pedro, J. San, et al.
(författare)
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On development and evaluation of prototype mobile decision support for hospital triage
- 2005
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Ingår i: Proceedings of the 38th Annual Hawaii International Conference on System Sciences. - Los Alamitos, Calif : IEEE Communications Society. - 0769522688
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Konferensbidrag (refereegranskat)abstract
- Ambiguous triage scenarios in hospital emergency departments are often difficult to assess without decision support. Subjective assessments of such scenarios can either lead to under-triaging or over-triaging for which true conditions of patients are often not addressed within the required time. In this paper, we propose a decision support model that can guide a clinician when identifying the urgency of medical intervention when patient presents with ambiguous triage case. Our model is a heuristic approach that selects the best triage category, identifies corresponding discriminating attribute of the patient, and allows clinician to attach a level of confidence in the decision. We implemented this model as a mobile decision support system, called iTriage. Results of an initial evaluation of iTriage using fourteen paper-based adult triage scenarios showed that our model produced robust decisions for urgent scenarios. For non-urgent scenarios, the proposed model provided guidance especially when the scenarios were ambiguously stated.
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| 4. |
- Wootton, P. T., et al.
(författare)
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Tagging SNP haplotype analysis of the secretory PLA2-V gene, PLA2G5, shows strong association with LDL and oxLDL levels, suggesting functional distinction from sPLA2-IIA: results from the UDACS study
- 2007
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Ingår i: Hum Mol Genet. ; 16:12, s. 1437-44
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Tidskriftsartikel (refereegranskat)abstract
- Animal and human studies suggest that both secretory PLA2 (sPLA2)-V and sPLA2-IIA (encoded, respectively, by the neighbouring PLA2G5 and PLA2G2A genes) contribute to atherogenesis. Elevated plasma sPLA2-IIA predicts coronary heart disease (CHD) risk, but no mass assay for sPLA2-V is available. We previously reported that tagging single nucleotide polymorphism (tSNP) haplotypes of PLA2G2A are strongly associated with sPLA2-IIA mass, but not lipid levels. Here, we use tSNPs of the sPLA2-V gene to investigate the association of PLA2G5 with CHD risk markers. Seven PLA2G5 tSNPs genotypes, explaining >92% of the locus genetic variability, were determined in 519 patients with Type II diabetes (in whom PLA2G2A tSNP data was available), and defined seven common haplotypes (frequencies >5%). PLA2G5 and PLA2G2A tSNPs showed linkage disequilibrium (LD). Compared to the common PLA2G5 haplotype, H1 (frequency 34.9%), haplotypes H2-7 were associated with overall higher plasma LDL (P < 0.00004) and total cholesterol (P < 0.00003) levels yet lower oxLDL/LDL (P = 0.006) and sPLA2-IIA mass (P = 0.04), probably reflecting LD with PLA2G2A. Intronic tSNP (rs11573248), unlikely itself to be functional, distinguished H1 from LDL-raising haplotypes and may mark a functional site. In conclusion, PLA2G5 tSNP haplotypes demonstrate an association with total and LDL cholesterol and oxLDL/LDL, not seen with PLA2G2A, thus confirming distinct functional roles for these two sPLA2s.
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