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- Brosché, Sara, 1978, et al.
(författare)
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Effects of two realistic pharmaceutical mixtures on natural freshwater periphyton communities
- 2007
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Ingår i: Society of Environmental Toxicology and Chemistry Europe annual meeting, 20-24 May 2006, Porto, Portugal.
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Konferensbidrag (refereegranskat)abstract
- During the last decade pharmaceuticals have been established as an important class of environmental pollutants. Main route of entry into the environment is from their regular use, which makes effluents from sewage treatment plants important sources of pollution. According to data from standard ecotoxicological tests, pharmaceuticals rarely pose an immediate risk at environmentally realistic concentrations. In reality though, pharmaceuticals act as mixtures on whole biological communities. Whether, and to what extent ecological effects can be expected under these circumstances is unknown. Hence we investigated the effects of two mixtures consisting of 15-20 pharmaceuticals on natural freshwater periphyton communities. The mixture compositions were based on effluent data from two sewage treatments plants, Ryaverket (Göteborg, Sweden) and Châtillon-sur-Chalaronne (Lyon, France). Effects on periphytic bacteria were measured as changes in metabolic diversity (Ecolog®). For the algal part of the communities, changes in pigment pattern and species composition were measured. Clear community-level effects were observed for the two mixtures
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- Porsbring, Tobias, 1974, et al.
(författare)
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Effects of clotrimazole on the pigment composition of marine periphyton communities for use in predictive ecological mixture toxicity assessment
- 2006
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Ingår i: SETAC Europe 16th Annual Meeting, The Hague, The Netherlands.
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Konferensbidrag (övrigt vetenskapligt/konstnärligt)abstract
- Clotrimazole is a pharmaceutic fungicide classified as persistent and toxic according to EU Technical Guidance Document, and reaches the marine environment mainly from municipal waste water treatment plants together with several other pollutants. In a project to assess mixture toxicity of pharmaceuticals on microbial communities, clotrimazole effects on the development of periphyton were measured in two independent SWIFT tests in 2004 and 2005. Microalgal communities were precolonised in the Gullmar fjord on the west coast of Sweden on 1.5 cm2 glass discs. Following a 96h incubation in a concentration series of clotrimazole, periphyton pigment profiles were analysed using HPLC, and effects were calculated as Bray-Curtis dissimilarity indices. In both tests, a clotrimazole concentration of 11 microg/l had a significant effect on pigment composition with a NOEC of 3.45 microg/l (nominal). This indicates an approximately 5 times higher clotrimazole toxicity to algae than single species data, although comparisons to PEC values suggests a low risk for marine algae. However, the importance of clotrimazole for the risks of mixtures is further researched.
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