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Thrombopoietin rece...
Thrombopoietin receptor agonist (TPO-RA) treatment raises platelet counts and reduces anti-platelet antibody levels in mice with immune thrombocytopenia (ITP)
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- Kapur, Rick (author)
- Academic Medical Center of University of Amsterdam (AMC),University of Amsterdam
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- Aslam, Rukhsana (author)
- Saint Michael's Hospital
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- Speck, Edwin R. (author)
- Saint Michael's Hospital
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- Rebetz, Johan M. (author)
- Lund University,Lunds universitet,Trombocyt immunologi,Forskargrupper vid Lunds universitet,Platelet Immunology,Lund University Research Groups
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- Semple, John W. (author)
- Lund University,Lunds universitet,Trombocyt immunologi,Forskargrupper vid Lunds universitet,Platelet Immunology,Lund University Research Groups,University of Toronto,Saint Michael's Hospital
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(creator_code:org_t)
- 2019-05-30
- 2020
- English 4 s.
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In: Platelets. - : Informa UK Limited. - 0953-7104 .- 1369-1635. ; 31:3, s. 399-402
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Abstract
Subject headings
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- Immune thrombocytopenia (ITP) is an autoimmune bleeding disorder in which autoantibodies and/or autoreactive T cells destroy platelets and megakaryocytes in the spleen and bone marrow, respectively. Thrombopoietin receptor agonists (TPO-RA e.g. Romiplostim and Eltrombopag) have made a substantial contribution to the treatment of patients with ITP, which are refractory to first-line treatments and approximately 30% demonstrate sustained elevated platelet counts after drug tapering. How TPO-RA induce these sustained responses is not known. We analyzed the efficacy of a murine TPO-RA in a well-established murine model of active ITP. Treatment with TPO-RA (10 ug/kg, based on pilot dose escalation experiments) significantly raised the platelet counts in ITP-mice. Immunomodulation was assessed by measuring serum IgG anti-platelet antibody levels; TPO-RA-treated mice had significantly reduced IgG anti-platelet antibodies despite the increasing platelet counts. These results suggest that TPO-RA is not only an efficacious therapy but also reduces anti-platelet humoral immunity in ITP.
Subject headings
- MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin -- Hematologi (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Clinical Medicine -- Hematology (hsv//eng)
Keyword
- Immune thrombocytopenia (ITP)
- immunomodulation
- platelet antibodies
- platelet counts
- thrombopoietin receptor agonist (TPO-RA)
Publication and Content Type
- art (subject category)
- ref (subject category)
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