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Träfflista för sökning "WFRF:(Aspenberg K) srt2:(1988-1989)"

Sökning: WFRF:(Aspenberg K) > (1988-1989)

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1.
  • Aspenberg, P., et al. (författare)
  • Drug test chamber : a titanium implant for administration of biochemical agents to a standardized bone callus in situ
  • 1988
  • Ingår i: Journal of Biomedical Engineering. - : Elsevier BV. - 0141-5425. ; 10:1, s. 70-73
  • Tidskriftsartikel (refereegranskat)abstract
    • A titanium implant in which a conduit is gradually filled with ingrowing bone (the Bone Harvest Chamber) has been modified to allow continuous local treatment of the conduit tissue with biochemical agents. Implants were inserted bilaterally in rabbit tibiae. The tissue content of the bone ingrowth conduits was studied with histology, 99mTc-MDP scintimetry and measurements of total calcium content. Bone was formed in the conduit by endochondral formation starting at both ends and continuing until fusion in the middle. After 2 weeks the bone had not yet met in the middle where fibrous tissue was seen. In eight animals 3H-proline was applied via one of the chambers, with the contralateral chamber as a saline-treated control. The collagen of the harvested tissue from the 3H-proline treated side had a 3H-hydroxyproline content 1000 times greater than had the control side. The 'drug test chamber' makes possible the study of local effects of drugs on healing of mature bone in vivo.
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2.
  • Aspenberg, P., et al. (författare)
  • Failure of bone induction by bone matrix in adult monkeys
  • 1988
  • Ingår i: Journal of Bone and Joint Surgery: British Volume. - 0301-620X. ; 70:4, s. 625-627
  • Tidskriftsartikel (refereegranskat)abstract
    • Extraskeletal bone formation can be induced in rodents by implantation of demineralised bone matrix and such implantation has been used to treat bone defects in man, but it is uncertain if induction or merely conduction occurs. We studied bone induction in primates by excising segments of the fibulae of adult squirrel monkeys, defatting and demineralising them before reimplanting them into the quadriceps of the same animal. As a control experiment, rat matrix was prepared in exactly the same way and implanted in rats. After six weeks the implants were harvested and either ashed and analysed for calcium content or prepared for histology. In the rats, the calcium content indicated that about 20% of the original matrix had been replaced by new bone. In the monkeys the calcium content was about the same as that in normal body fluid and no bone was seen in histological sections. This result casts doubt on the use of demineralised human bone matrix as a bone inductor, although it may function by other mechanisms.
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  • Resultat 1-2 av 2
Typ av publikation
tidskriftsartikel (2)
Typ av innehåll
refereegranskat (2)
Författare/redaktör
Lohmander, Stefan (2)
Aspenberg, P (2)
Thorngren, K. G. (2)
Albrektsson, T. (1)
Lärosäte
Lunds universitet (2)
Språk
Engelska (2)
Forskningsämne (UKÄ/SCB)
Medicin och hälsovetenskap (2)
År
1988 (2)

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