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- Aspengren, Sara, 1977, et al.
(författare)
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Effects of Hydroquinone on Cytoskeletal Organization and Intracellular Transport in Cultured Xenopus laevis Melanophores and Fibroblasts
- 2012
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Ingår i: ISRN Cell Biology. - : Hindawi Limited. - 2356-7872 .- 2090-7389. ; 2012
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Tidskriftsartikel (refereegranskat)abstract
- Hydroquinone is used as a skin-lightening agent, it is also present in different chemical products and cigarette smoke. It is believed to inhibit melanin production in melanocytes by inhibiting the key enzyme tyrosinase. In the present study, we show that hydroquinone had severe effects on microtubules and actin filaments in cultured Xenopus laevis melanophores as studied by immunohistochemistry. It affected the intracellular transport of melanosomes, induced bundling of microtubules and disassembly of actin filaments at 10 and 50μM, and at 100μM proper adhesion to the substrate was lost. Effects occurred at lower concentrations than what previously has been stated to be cytotoxic, and the results show that tyrosinase is not the only cellular target. The cytoskeleton is of utmost importance for the function of all cells and across species. Our data has therefore to be considered in the discussions about the use of hydroquinone for bleaching of skin.
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| 2. |
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| 3. |
- Nilsson Sköld, Helen, 1970, et al.
(författare)
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Rapid color change in fish and amphibians - function, regulation, and emerging applications.
- 2013
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Ingår i: Pigment Cell & Melanoma Research. - : Wiley. - 1755-1471 .- 1755-148X. ; 26:1, s. 29-38
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Forskningsöversikt (refereegranskat)abstract
- Physiological color change is important for background matching, thermoregulation as well as signaling and is in vertebrates mediated by synchronous intracellular transport of pigmented organelles in chromatophores. We describe functions of and animal situations where color change occurs. A summary of endogenous and external factors that regulate this color change in fish and amphibians is provided, with special emphasis on extracellular stimuli. We describe not only color change in skin, but also highlight studies on color change that occurs using chromatophores in other areas such as iris and on the inside of the body. In addition, we discuss the growing field that applies melanophores and skin color in toxicology and as biosensors, and point out research areas with future potential.
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