| 1. |
- Axelson, Olav, 1937-, et al.
(författare)
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Regulatory toxicology and pharmacology.
- 2003
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Ingår i: International journal of occupational and environmental health. - 1077-3525 .- 2049-3967. ; 9, s. 386-389
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Tidskriftsartikel (refereegranskat)
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| 2. |
- Buzio, L, et al.
(författare)
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Glutathione S-transferases M1-1 and T1-1 as risk modifiers for renal cell cancer associated with occupational exposure to chemicals
- 2003
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Ingår i: Occupational and Environmental Medicine. - : BMJ. - 1351-0711 .- 1470-7926. ; 60:10, s. 789-793
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Tidskriftsartikel (refereegranskat)abstract
- Aims: To investigate the possible interaction between occupational risk factors and genotype for glutathione S-transferases M1 and T1 (GSTM1 and GSTT1) in renal cell cancer (RCC). Methods: One hundred patients with RCC and 200 outpatient controls were enrolled at Parma University Hospital. The polymorphisms of glutathione S-transferase M1-1 (GSTM1) and T1-1 (GSTT1) were investigated by PCR, occupational history was collected by a structured questionnaire. Results: Subjects with GSTM1 present genotype showed higher risks for RCC, compared to GSTM1 null subjects, if exposed to metals (OR 2.73, 95% CI 0.91 to 8.22 v 1.14, 95% CI 0.46 to 2.82) or pesticides (OR 3.46, 95% CI 1.12 to 10.74 v 1.59, 95% CI 0.48 to 5.34). The GSTT1 present genotype also enhanced the risk (about twofold) of RCC among subjects exposed to solvents and pesticides, compared with those GSTT1 null. Conclusions: Results support the hypothesis that GSTM1 and GSTT1 polymorphisms can interact with several occupational exposures to significantly modify the risk of RCC among exposed subjects.
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| 3. |
- Hardell, Lennart, et al.
(författare)
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Epidemiological studies on cancer and exposure to dioxins and related compounds.
- 2003. - 2
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Ingår i: Dioxins and health. - Linköping : Linköpings universitet. - 0471433551 - 9780471433552 ; , s. 729-764
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Bokkapitel (övrigt vetenskapligt/konstnärligt)abstract
- Now in its third edition, Dioxins and Healthis the most respected reference of its kind, presenting the latest scientific findings on dioxins, dibenzofurans, polychlorinated biphenyls and related compounds, and their impact on human health. The book fully examines the many toxicological effects—including immunological, neurological, developmental, dermatological, and cardiological—these chemicals have on health.This Third Editionhas been greatly expanded with the latest research findings on dioxins and related compounds. Moreover, it now includes coverage of other persistent organic pollutants (POPs) and endocrine disruptors, including:Brominated flame retardants, such as polybrominated diphenyl ethers and hexabromocyclododecanePerfluorinated chemicals such as perfluorooctanoic acid and perfluorooctanesulfonic acidOther endocrine disrupting chemicals similar to POPs such as bisphenol AReaders will also learn about the latest findings on the long-term impacts caused by the use of Agent Orange in Vietnam. Other chapters review the Seveso disaster in Italy and the Yusho and Yucheng rice oil poisoning incidents in Japan and Taiwan. In addition, there is a full chapter dedicated to the dioxin poisoning of former Ukraine President Victor Yushchenko.All the chapters in the book have been written by leading international experts. References at the end of each chapter guide readers to the primary literature in the field.Expertly organized in one volume, Dioxins and Health offers readers quick access to essential information about dioxins and related compounds written in clear, simple language that is accessible to not only scientists, clinicians and public health professionals, but also general readers.
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| 4. |
- Mai, Xiaomei, 1969-, et al.
(författare)
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High body mass index, asthma and allergy in Swedish schoolchildren participating in the International Study of Asthma and Allergies in Childhood : phase II
- 2003
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Ingår i: Acta Paediatrica. - 0803-5253 .- 1651-2227. ; 92:10, s. 1144-1148
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Tidskriftsartikel (refereegranskat)abstract
- Aim: To assess the relationship between high body mass index (BMI) and asthma and atopic manifestations in 12-y-old children.Methods: The relationship between high BMI and asthma symptoms was studied in 457 sixth-grade children, with (n= 161) and without (n= 296) current wheeze. High BMI was defined as ±75th percentile of gender-specific BMI reference values for Swedish children at 12 y of age; overweight as a subgroup of high BMI was defined as ±95th percentile. Children with a BMI >75th percentile served as controls. Questionnaires were used to assess asthmatic and allergic symptoms, and bronchial hyperresponsiveness was assessed by hypertonic saline provocation tests.Results: Current wheeze was associated with high BMI after adjustment for confounding factors (adjusted OR 1.7, 95% CI 1.0–2.5) and overweight had an even more pronounced effect (adjusted OR 1.9, 95% CI 1.0–3.6). In addition, asthma severity was associated with high BMI, as evaluated by the number of wheezing episodes during the previous 12 mo among the wheezing children (adjusted OR 2.0, 95% CI 1.0–4.0). There was also an association between high BMI and the presence of eczema in wheezing children (adjusted OR 2.2, 95% CI 1.0–4.6). However, high BMI was not significantly associated with hay fever, positive skin prick tests or bronchial hyperresponsiveness.Conclusion: The study confirms and extends a previously observed relationship between BMI and the presence of wheezing and asthma.
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| 5. |
- Settimi, Laura, et al.
(författare)
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Prostate cancer and exposure to pesticides in agricultural settings
- 2003
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Ingår i: International Journal of Cancer. - : Wiley. - 0020-7136 .- 1097-0215. ; 104:4, s. 458-461
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Tidskriftsartikel (refereegranskat)abstract
- Our study evaluates the association between prostate cancer and exposure to pesticides in agricultural settings in Italy. The data were derived from a hospital-based multi-site case-control study carried out in 5 rural areas between 1990–92. In our study, 124 new cases of prostate cancer were ascertained and interviewed, along with 659 cancer controls. A team of agronomists assessed past exposure to pesticides by using a checklist of 100 chemical families and 217 compounds applied from 1950–85 in the areas considered. The association between prostate cancer and different occupational risk factors was measured by maximum likelihood estimation of the odds ratio, controlling for potential confounders. “Ever been employed in agriculture” was associated with a 40% increased risk (OR = 1.4, 95% CI = 0.9–2.0). Prostate cancer was also related positively to food and tobacco (OR= 2.1, 95% CI = 1.1–4.1), and chemical products (OR = 2.2, 95% CI = 0.7–7.2) industries. The analyses carried out to estimate the association between different types of pesticides and prostate cancer showed increased risks among farmers exposed to organochlorine insecticides and acaricides (OR = 2.5, 95% CI = 1.4–4.2), more specifically to the often contemporary used compounds DDT (OR = 2.1, 95% CI = 1.2–3.8), and dicofol (OR = 2.8, 95% CI = 1.5–5.0), whose effects could not be well separated.
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| 6. |
- Tondel, Martin, 1962-, et al.
(författare)
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Increased cancer incidence in north Sweden-an early promoting effect caused by the chernobyl accident.
- 2003
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Ingår i: Epidemiology. - : Lippincott Williams & Wilkins. - 1044-3983. ; 14:5 Suppl., s. S94-S94
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Tidskriftsartikel (övrigt vetenskapligt/konstnärligt)abstract
- Introduction: In Sweden the ground gamma radiation, due to uranium containing granite, contribute to the population's total radiation dose. After the Chemobyl nuclear power plant accident in 1986 as much as five percent of the released caesium-137 was deposited in Sweden, especially in the Northern part of the country. Our hypothesis was that this radiation caused increased cancer incidence, after adjustment by ground gamma radiation exposure.Methods: The study base included the population of eight counties with the highest fallout after the Chernobyl accident, but also with unaffected areas in these counties serving as the reference. Each person 0-60 years of age living in the same parish at 31 December 1985 and 31 December 1987 were included in a cohort. With the coordinate of each person's dwelling from the National Land Survey of Sweden a total of 1 137 106 individuals could be given 1) ground gamma radiation exposure from the digital map of the Swedish Geological Agency and 2) caesium-137 exposure from a similar map created by Swedish Radiation Protection Institute. Accuracy of the dwelling coordinate was 100 metres and for the radiation exposures 200 metres as done by aeroplane measurements. Three time periods were analysed 1988-1991, 1992-1995 and 1988-1999.Results: Population density, lung cancer incidence 1988-1999 and total cancer incidence 1986-1987 was risk factors for total cancer outcome in 1988-1999. Age adjusted ERR per 100 nGy/h for ground gamma radiation and total cancer incidence did not show any significant dose response measured, either in each three years time intervals or in the total period of 1988-1999. For caesium the ERR per 100 nGy/h (adjusted by population density, lung cancer incidence, total cancer incidence 1986-1987 and ground gamma radiation) was significant in 1988-1991 followed by a decline in risk 1992-1995 and then a slight but not complete return in risk. The ERR of 0.042 (95% CL 0.001;0.084) per 100 nGy/h for caesium exposure 1988-1999 is therefore dependent on the first three years increase, and to less extent by the following six years.Conclusion: We have found an early effect of the Chernobyl fallout in Northern Sweden. However, even in the ERR of 0.101 per 100 nGy/h is relatively low in 1988-1991, it is stable in a stepwise regression, and therefore indicating a true effect. An interpretation of our results could be that the sudden exposure of ionizing radiation from Chernobyl might have acted as a late stage general promotor for cancer. Such an early effect can hitherto been overlooked in previous studies.
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