| 1. |
- Ahmadi Mehri, Vida
(författare)
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Towards Automated Context-aware Vulnerability Risk Management
- 2023
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Doktorsavhandling (övrigt vetenskapligt/konstnärligt)abstract
- The information security landscape continually evolves with increasing publicly known vulnerabilities (e.g., 25064 new vulnerabilities in 2022). Vulnerabilities play a prominent role in all types of security related attacks, including ransomware and data breaches. Vulnerability Risk Management (VRM) is an essential cyber defense mechanism to eliminate or reduce attack surfaces in information technology. VRM is a continuous procedure of identification, classification, evaluation, and remediation of vulnerabilities. The traditional VRM procedure is time-consuming as classification, evaluation, and remediation require skills and knowledge of specific computer systems, software, network, and security policies. Activities requiring human input slow down the VRM process, increasing the risk of exploiting a vulnerability.The thesis introduces the Automated Context-aware Vulnerability Risk Management (ACVRM) methodology to improve VRM procedures by automating the entire VRM cycle and reducing the procedure time and experts' intervention. ACVRM focuses on the challenging stages (i.e., classification, evaluation, and remediation) of VRM to support security experts in promptly prioritizing and patching the vulnerabilities. ACVRM concept is designed and implemented in a test environment for proof of concept. The efficiency of patch prioritization by ACVRM compared against a commercial vulnerability management tool (i.e., Rudder). ACVRM prioritized the vulnerability based on the patch score (i.e., the numeric representation of the vulnerability characteristic and the risk), the historical data, and dependencies. The experiments indicate that ACVRM could rank the vulnerabilities in the organization's context by weighting the criteria used in patch score calculation. The automated patch deployment is implemented with three use cases to investigate the impact of learning from historical events and dependencies on the success rate of the patch and human intervention. Our finding shows that ACVRM reduced the need for human actions, increased the ratio of successfully patched vulnerabilities, and decreased the cycle time of VRM process.
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| 2. |
- Al Musawi, Ahmed, et al.
(författare)
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Intervention for a correct medication list and medication use in older adults : a non-randomised feasibility study among inpatients and residents during care transitions
- 2024
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Ingår i: International Journal of Clinical Pharmacy. - : Springer. - 2210-7703 .- 2210-7711. ; 46, s. 639-647
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Tidskriftsartikel (refereegranskat)abstract
- BackgroundMedication discrepancies in care transitions and medication non-adherence are problematic. Few interventions consider the entire process, from the hospital to the patient's medication use at home.AimIn preparation for randomised controlled trials (RCTs), this study aimed (1) to investigate the feasibility of recruitment and retention of patients, and data collection to reduce medication discrepancies at discharge and improve medication adherence, and (2) to explore the outcomes of the interventions.MethodParticipants were recruited from a hospital and a residential area. Hospital patients participated in a pharmacist-led intervention to establish a correct medication list upon discharge and a follow-up interview two weeks post-discharge. All participants received a person-centred adherence intervention for three to six months. Discrepancies in the medication lists, the Beliefs about Medicines Questionnaire (BMQ-S), and the Medication Adherence Report Scale (MARS-5) were assessed.ResultsOf 87 asked to participate, 35 were included, and 12 completed the study. Identifying discrepancies, discussing discrepancies with physicians, and performing follow-up interviews were possible. Conducting the adherence intervention was also possible using individual health plans for medication use. Among the seven hospital patients, 24 discrepancies were found. Discharging physicians agreed that all discrepancies were errors, but only ten were corrected in the discharge information. Ten participants decreased their total BMQ-S concern scores, and seven increased their total MARS-5 scores.ConclusionBased on this study, conducting the two RCTs separately may increase the inclusion rate. Data collection was feasible. Both interventions were feasible in many aspects but need to be optimised in upcoming RCTs.
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| 3. |
- Grill, Filip, et al.
(författare)
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Dissecting Motor and Cognitive Component Processes of a Finger-Tapping Task With Hybrid Dopamine Positron Emission Tomography and Functional Magnetic Resonance Imaging
- 2021
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Ingår i: Frontiers in Human Neuroscience. - : Frontiers Media S.A.. - 1662-5161. ; 15
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Tidskriftsartikel (refereegranskat)abstract
- Striatal dopamine is involved in facilitation of motor action as well as various cognitive and emotional functions. Positron emission tomography (PET) is the primary imaging method used to investigate dopamine function in humans. Previous PET studies have shown striatal dopamine release during simple finger tapping in both the putamen and the caudate. It is likely that dopamine release in the putamen is related to motor processes while dopamine release in the caudate could signal sustained cognitive component processes of the task, but the poor temporal resolution of PET has hindered firm conclusions. In this study we simultaneously collected [11C]Raclopride PET and functional Magnetic Resonance Imaging (fMRI) data while participants performed finger tapping, with fMRI being able to isolate activations related to individual tapping events. The results revealed fMRI-PET overlap in the bilateral putamen, which is consistent with a motor component process. Selective PET responses in the caudate, ventral striatum, and right posterior putamen, were also observed but did not overlap with fMRI responses to tapping events, suggesting that these reflect non-motor component processes of finger tapping. Our findings suggest an interplay between motor and non-motor-related dopamine release during simple finger tapping and illustrate the potential of hybrid PET-fMRI in revealing distinct component processes of cognitive functions.
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| 4. |
- Johansson, Patrik, PhD, 1972-, et al.
(författare)
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Upptäck historien genom källorna
- 2023. - 2
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Ingår i: Historiedidaktik i praktiken. - Malmö : Gleerups Utbildning AB. - 9789151108810 ; , s. 107-142
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Bokkapitel (populärvet., debatt m.m.)abstract
- Att undervisa i historia är både roligt och utmanande. Historieämnets berättande tradition innebär att undervisningen lätt kan göras medryckande med hjälp av färgstarka händelser och personer. Eleverna kan ges möjlighet att leva sig in i levnadsvillkor under andra tider och betrakta sina egna liv som en del av historiens gång. Föreställningarna om dåtid, nutid och framtid samspelar med varandra, och det är lärarens uppdrag att hjälpa eleverna att utveckla sin förmåga att relatera de olika tidsskikten till varandra. Detta är viktigt men inte alltid enkelt, och historieundervisningen ställer höga krav på både lärare och elever. Historiedidaktik i praktiken – för lärare 4-9 är en introduktion till undervisning i historia i grundskolan och tydligt grundad i historiedidaktisk teoribildning. Resonemangen i boken är praktiknära och knyter an till kursplanen i historia för grundskolan. Kärnan i boken utgörs av fyra kapitel som behandlar centrala kunskaper i historia: historiska referensramskunskaper, hantering av historiska källor, historieanvändning och historiska begrepp. Dessa diskuteras utifrån ett undervisningsperspektiv, där lärarens didaktiska val står i centrum. I bokens övriga kapitel diskuteras specifika aspekter av historieämnet i relation till undervisningen: begreppet historiemedvetande, bedömning i historia, samt vad forskningen säger om yngre barns lärande av historia. Bokens andra upplaga är utvidgad till att omfatta både årskurserna 4-6 och 7-9, och kan även vara användbar för lärare på gymnasienivå.
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| 5. |
- Jonasson, My, et al.
(författare)
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Striatal dopamine transporter and receptor availability correlate with relative cerebral blood flow measured with [11C]PE2I, [18F]FE-PE2I and [11C]raclopride PET in healthy individuals
- 2023
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Ingår i: Journal of Cerebral Blood Flow and Metabolism. - : Sage Publications. - 0271-678X .- 1559-7016. ; 43:7, s. 1206-1215
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Tidskriftsartikel (refereegranskat)abstract
- The aim of this retrospective study was to investigate relationships between relative cerebral blood flow and striatal dopamine transporter and dopamine D2/3 availability in healthy subjects. The data comprised dynamic PET scans with two dopamine transporter tracers [11C]PE2I (n = 20) and [18F]FE-PE2I (n = 20) and the D2/3 tracer [11C]raclopride (n = 18). Subjects with a [11C]PE2I scan also underwent a dynamic scan with the serotonin transporter tracer [11C]DASB. Binding potential (BPND) and relative tracer delivery (R1) values were calculated on regional and voxel-level. Striatal R1 and BPND values were correlated, using either an MRI-based volume of interest (VOI) or an isocontour VOI based on the parametric BPND image. An inter-tracer comparison between [11C]PE2I BPND and [11C]DASB R1 was done on a VOI-level and simulations were performed to investigate whether the constraints of the modeling could cause correlation of the parameters. A positive association was found between BPND and R1 for all three dopamine tracers. A similar correlation was found for the inter-tracer correlation between [11C]PE2I BPND and [11C]DASB R1. Simulations showed that this relationship was not caused by cross-correlation between parameters in the kinetic model. In conclusion, these results suggest an association between resting-state striatal dopamine function and relative blood flow in healthy subjects.
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| 6. |
- Pettersson, Mio, 1990-, et al.
(författare)
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Sampling of per- and polyfluoroalkyl substances in drainage water from a waste management facility
- 2024
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Ingår i: Chemosphere. - : Elsevier. - 0045-6535 .- 1879-1298. ; 364
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Tidskriftsartikel (refereegranskat)abstract
- Per- and polyfluoroalkyl substances (PFAS) have been used for decades in a broad range of consumer products and industrial applications. A variety of waste and products containing PFAS inevitably end up at waste management facilities when they are no longer considered useful. Drainage water samples (n = 157) were collected from eight subsections at a waste management facility in Sweden and analyzed for 23 PFAS and extractable organofluorine (EOF). Two different sampling methods were used, grab sampling (n = 32, without filtration) and composite sampling (n = 8, produced by pooling 16 filtered samples taken at the same subsection). Although PFAS have been studied at waste sites, the information is scarce regarding how the concentrations and homologue profiles could differ within the sites. In this study, we investigated if composite sampling could be an alternative to grab sampling for PFAS monitoring purposes. Herein, the PFAS concentrations ranged from <1 to 22 μg/L; the grab samples showed systematic higher concentrations than their corresponding composite sample. Short-chain perfluoroalkyl sulfonic acids (C4 and C5) were the largest contributing sub-class, followed by short-chain perfluoroalkyl carboxylic acids (C4 to C6). EOF was measured up to approximately 140 μg/L F with 99% being unexplained by the fluorine mass balance analysis. The results from this study showed that both sampling methods were comparable for target analysis and that 11 compounds represented most of the PFAS concentrations. However, the discrepancy between the sampling methods was greater for EOF analysis and may be due to the preparation of composite samples and/or due to fluctuating discharges during the sampling period. Composite sampling was observed to be comparable to grab sampling for target analysis.
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| 7. |
- Rutegård, Miriam, et al.
(författare)
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Rectal cancer : a methodological approach to matching PET/MRI to histopathology
- 2020
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Ingår i: Cancer Imaging. - : BioMed Central (BMC). - 1740-5025 .- 1470-7330. ; 20:1
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Tidskriftsartikel (refereegranskat)abstract
- Purpose: To enable the evaluation of locoregional disease in the on-going RECTOPET (REctal Cancer Trial on PET/MRI/CT) study; a methodology to match mesorectal imaging findings to histopathology is presented, along with initial observations.Methods: FDG-PET/MRI examinations were performed in twenty-four consecutively included patients with rectal adenocarcinoma. In nine patients, of whom five received neoadjuvant treatment, a postoperative MRI of the surgical specimen was performed. The pathological cut-out was performed according to clinical routine with the addition of photo documentation of each slice of the surgical specimen, meticulously marking the location, size, and type of pathology of each mesorectal finding. This allowed matching individual nodal structures from preoperative MRI, via the specimen MRI, to histopathology.Results: Preoperative MRI identified 197 mesorectal nodal structures, of which 92 (47%) could be anatomically matched to histopathology. Of the matched nodal structures identified in both MRI and histopathology, 25% were found to be malignant. These malignant structures consisted of lymph nodes (43%), tumour deposits (48%), and extramural venous invasion (9%). One hundred eleven nodal structures (55%) could not be matched anatomically. Of these, 97 (87%) were benign lymph nodes, and 14 (13%) were malignant nodal structures. Five were malignant lymph nodes, and nine were tumour deposits, all of which had a short axis diameter < 5 mm.Conclusions: We designed a method able to anatomically match and study the characteristics of individual mesorectal nodal structures, enabling further research on the impact of each imaging modality. Initial observations suggest that small malignant nodal structures assessed as lymph nodes in MRI often comprise other forms of mesorectal tumour spread.Trial registration: Clinical Trials Identifier: NCT03846882.
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