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Träfflista för sökning "WFRF:(Ayad A) srt2:(2012-2014)"

Sökning: WFRF:(Ayad A) > (2012-2014)

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1.
  • Costa, Tiago R. D., et al. (författare)
  • Coiled-coils in the YopD translocator family : A predicted structure unique to the YopD N-terminus contributes to full virulence of Yersinia pseudotuberculosis
  • 2012
  • Ingår i: Infection, Genetics and Evolution. - : Elsevier. - 1567-1348 .- 1567-7257. ; 12:8, s. 1729-1742
  • Tidskriftsartikel (refereegranskat)abstract
    • Pathogenic Yersinia all harbor a virulence plasmid-encoded Ysc–Yop T3SS. In this system, translocator function is performed by the hydrophobic proteins YopB and YopD. With the goal to better understand how YopD orchestrates yop-regulatory control, translocon pore formation and Yop effector translocation, we performed an in silico prediction of coiled-coil motifs in YopD and YopD-like sequences from other bacteria. Of interest was a predicted N-terminal coiled-coil that occurred solely in Yersinia YopD sequences. To investigate if this unique feature was biologically relevant, two in cis point mutations were generated with a view to disrupting this putative structure. Both mutants maintained full T3SS function in vitro in terms of environmental control of Yops synthesis and secretion, effector toxin translocation and evasion of phagocytosis and killing by cultured immune cells. However, these same mutants were attenuated for virulence in a murine oral-infection model. The cause of this tardy disease progression is unclear. However, these data indicate that any structural flaw in this element unique to the N-terminus will subtly compromise an aspect of YopD biology. Sub-optimal T3SSs are then formed that are unable to fortify Yersinia against attack by the host innate and adaptive immune response.
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2.
  • Faisal, Ayad A. H., et al. (författare)
  • Modeling of Trichloroethylene Migration in Three-Dimensional Saturated Sandy Soil
  • 2014
  • Ingår i: Arabian Journal for Science and Engineering. - : Springer. - 2193-567X .- 2191-4281 .- 1319-8025. ; 39:11, s. 7763-7769
  • Tidskriftsartikel (refereegranskat)abstract
    • This study characterized the temporal and spatial distribution of trichloroethylene (TCE) dissolved plume from continuous source in 3D bench-scale sand aquifer. COMSOL Multiphysics 3.5a (2008) software based on the finite element numerical scheme taking into account the sorption process was used to interpreted the experimental results. A conservative tracer is employed for the determination of the longitudinal dispersivity. The sorption characteristics of TCE onto the aquifer sand are independently determined from batch equilibrium data. TCE concentrations at specific downstream locations within the aquifer for different periods of time are measured under flow rates values equal to 20, 40 and 100 ml/min. The predicted TCE concentrations were found to be reasonably agreed with the bench-scale experimental results with mean error <5%.
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